Efficacy of two novel behavioral post-cessation weight gain interventions

两种新颖的戒烟后体重增加行为干预措施的功效

基本信息

批准号：
9342879
负责人：
Rebecca A. Krukowski
金额：
$ 67.49万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-05 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9342879
关键词：
Attenuated Behavior Therapy Behavioral Bibliotherapy Blood Pressure Body Weight Body Weight Changes Body Weight decreased Books Data Ethnic Origin Focus Groups Frequencies Goals Group Interviews Health Health Benefit Individual Intervention Measures Mediator of activation protein Methods Minority Groups Morbidity - disease rate Obesity Participant Persons Pharmaceutical Preparations Pharmacotherapy Process Race Randomized Smoker Smoking Cessation Intervention Translating Treatment Efficacy Treatment outcome Vulnerable Populations Weight Weight Gain Weight maintenance regimen Woman arm base clinically significant ethnic minority population evidence base follow-up glucose metabolism high risk lifestyle intervention mortality novel prevent primary outcome programs racial minority skills smoking cessation smoking relapse varenicline weight loss intervention weight maintenance

项目摘要

While smoking cessation leads to significant improvements in mortality and morbidity, weight gain post- cessation partially attenuates this benefit. Furthermore, concerns about postcessation weight gain are common and are often cited as a reason to delay cessation attempts. In addition, postcessation weight gain is associated with smoking relapse. Thus, although the health benefits of smoking cessation outweigh the negative impact of weight gain, ideally there would be intervention “packages” that would not require that people choose between smoking cessation and nontrivial weight gain. Thus, in the proposed study, we will determine whether two very promising methods of reducing postcessation weight gain, namely a weight stability intervention (based on the evidence-based Stability Skills First intervention) versus a weight loss intervention (based on the evidence-based Look AHEAD intensive lifestyle intervention) followed by a smoking cessation intervention are efficacious for reducing postcessation weight gain. We will randomize 400 smokers to one of three arms: a) a weight stability intervention prior to cessation (STABLE); b) a weight loss intervention prior to cessation (LOSS), or c) a bibliotherapy comparison condition prior to cessation (BIBLIO) and to determine the efficacy of the interventions on preventing weight gain at 12 month follow-up. All three conditions receive a highly efficacious in-person smoking cessation behavioral intervention and six months of Varenicline (ChantixTM) pharmacotherapy. Those participants randomized to the STABLE and LOSS conditions will receive monthly booster weight management sessions, after completing the behavioral smoking cessation intervention. The primary outcomes will be weight change and smoking cessation at 12 month follow-up. In addition, we will gather process data on mediators of treatment outcome via measures of treatment engagement (e.g., session attendance, varenicline utilization). We will be able to determine whether a weight stability intervention or a weight loss intervention is efficacious in reducing post-cessation weight gain. The intervention results, if successful, could be disseminated and make a significant contribution towards curtailing obesity in this vulnerable population.

虽然戒烟可显着降低死亡率和发病率，但戒烟后体重增加此外，戒烟后体重增加的担忧也很常见。此外，戒烟后体重增加也是延迟戒烟尝试的一个原因。因此，尽管戒烟对健康的益处大于戒烟的益处。体重增加的负面影响，理想情况下会有不需要的干预“方案” 人们在戒烟和显着的体重增加之间做出选择。因此，在拟议的研究中，我们将进行选择。确定是否有两种非常有希望的减少戒烟后体重增加的方法，即体重稳定性干预（基于循证稳定性技能第一干预）与减肥干预（基于基于证据的 Look AHEAD 强化生活方式干预），然后吸烟戒烟干预对于减少戒烟后体重增加有效我们将随机抽取 400 名吸烟者。三个组之一：a) 戒烟前的体重稳定性干预（稳定）；b) 减肥干预；停止前 (LOSS)，或 c) 停止前的阅读疗法比较条件 (BIBLIO) 以及确定干预措施在 12 个月随访时预防体重增加的功效。接受高效的面对面戒烟行为干预和六个月的 Varenicline (ChantixTM) 药物治疗那些随机分配到稳定和丢失条件的参与者将。完成行为戒烟后，每月接受加强体重管理课程干预的主要结果是 12 个月随访时的体重变化和戒烟。此外，我们将通过治疗措施收集有关治疗结果中介因素的过程数据我们将能够确定是否有权重。稳定性干预或减肥干预可有效减少戒烟后体重增加。干预结果如果成功，可以传播并为减少污染做出重大贡献这一弱势群体的肥胖问题。