Role of nutrition in the Control of Immunity

营养在免疫控制中的作用

• 批准号: 9566725
• 负责人: Yasmine Belkaid
• 金额: $ 40.99万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9566725
• 关键词: Age; Antigen-Presenting Cells; Cell physiology; Cells; Child; Chronic; Communicable Diseases; Cues; Dendritic Cells; Development; Disease; Immune; Immune response; Immune system; Immunity; Immunosuppression; Inflammatory; Intestines; Malnutrition; Metabolic; Metabolic syndrome; Micronutrients; Modeling; Mus; Natural Immunity; Nursery Schools; Nutrient; Nutritional; Population; Pregnant Women; Role; Signal Transduction; T-Lymphocyte; Tretinoin; Vaccines; Viral Tumor Antigens; Vitamin A; Vitamin A Deficiency; Work; adaptive immunity; immune system function; microbiota; micronutrient deficiency; mortality; novel; nutrition; oral tolerance; pathogen; receptor; response; retinoic acid receptor alpha

Using complementary approaches of micronutrient deficiencies and mice for which responses to defined micronutrients was abrogated in T cells or antigen presenting cells, we identified a previously unrecognized role for retinoic acid and its receptor, retinoic acid receptor alpha in the control of T cell and dendritic cells function and development. Notably, we found that RA regulates pre-cDC differentiation and that vitamin A deficiency has major consequences on the development of mucosal dendritic cells. Our work further explored how the immune system adapts to various states of malnutrition and demonstrated that defined aspect of innate immunity could be metabolicaly boosted to compensate for defective adaptive immunity under these settings. We also developed novel models of nutrient deficiency and integrated the exploration of the microbiota to these questions.

使用微营养素缺陷和小鼠的互补方法在T细胞或抗原呈递细胞中废除了对所定义的微量营养素的反应，我们确定了视黄酸及其受体维甲酸受体，维甲酸受体alpha在T细胞和树突状细胞对照中的作用和开发和开发的作用。值得注意的是，我们发现RA可以调节CDC前分化，并且维生素A缺乏对粘膜树突状细胞的发展产生了重大影响。我们的工作进一步探讨了免疫系统如何适应营养不良的各种状态，并证明可以为先天免疫的定义方面提供代谢性，以弥补这些环境下有缺陷的适应性免疫。我们还开发了营养缺乏症的新型模型，并将菌群的探索纳入了这些问题。