Role of nutrition in the Control of Immunity

营养在免疫控制中的作用

• 批准号: 8946505
• 负责人: Yasmine Belkaid
• 金额: $ 24.58万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8946505
• 关键词: Address; Age; Antigen-Presenting Cells; Cell physiology; Cells; Child; Chronic; Communicable Diseases; Cues; Dendritic Cells; Development; Disease; Gastrointestinal tract structure; Immune; Immune response; Immune system; Immunity; Immunosuppression; Inflammatory; Intestines; Malnutrition; Metabolic syndrome; Micronutrients; Mus; Nursery Schools; Nutrient; Nutritional; Pathology; Pregnant Women; Role; Signal Transduction; T cell response; T-Lymphocyte; Tretinoin; Vitamin A; Vitamin A Deficiency; Work; micronutrient deficiency; mortality; nutrition; oral tolerance; receptor; response; retinoic acid receptor alpha; Address; Age; Antigen-Presenting Cells; Cell physiology; Cells; Child; Chronic; Communicable Diseases; Cues; Dendritic Cells; Development; Disease; Gastrointestinal tract structure; Immune; Immune response; Immune system; Immunity; Immunosuppression; Inflammatory; Intestines; Malnutrition; Metabolic syndrome; Micronutrients; Mus; Nursery Schools; Nutrient; Nutritional; Pathology; Pregnant Women; Role; Signal Transduction; T cell response; T-Lymphocyte; Tretinoin; Vitamin A; Vitamin A Deficiency; Work; micronutrient deficiency; mortality; nutrition; oral tolerance; receptor; response; retinoic acid receptor alpha

Using complementary approaches of vitamin A deficiency and mice for which response to the vitamin A metabolite RA, was abrogated in T cells, we identified a previously unrecognized role for retinoic acid and its receptor, retinoic acid receptor alpha in the control of dendritic cells function and development. Notably, we found that RA regulates pre-cDC differentiation and that vitamin A deficiency has major consequences on the development of mucosal dendritic cells. Further our work reveals how the immune system adapts to various states of malnutrition by boosting defined aspects of innate responses.

使用维生素A缺乏症和小鼠的互补方法在T细胞中废除了对维生素A代谢产物RA的反应，我们确定了视黄酸及其受体视黄酸受体Alpha在树枝状细胞功能和发育中的控制中的先前未识别的作用。值得注意的是，我们发现RA可以调节CDC前分化，并且维生素A缺乏对粘膜树突状细胞的发展产生了重大影响。此外，我们的工作还揭示了免疫系统如何通过促进先天反应的定义方面来适应营养不良的各种状态。