Genetic and Environmental Influences on Addiction

遗传和环境对成瘾的影响

• 批准号: 9278481
• 负责人: Teresa A Milner
• 金额: $ 14.21万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278481
• 关键词: Genetic; addiction

Abstract: Understanding how genetic and environmental factors impact drug use and abuse may be critical for addiction prevention and diagnosis, as well as the development of novel effective addiction therapeutics. This application plans to provide 3 predoctoral training slots (for ~2 yrs, starting in the 2nd yr) in the Weill Cornell Graduate School (WCGS) Neuroscience and Pharmacology Programs aimed at understanding the impact of genes and environment on drug addiction. A unique feature of this training plan is the diversity of faculty expertise in both genetic (e.g. sex, single nucleotide polymorphisms, gene splice variants, dendritic/axonal translation, and epigenetics) and environmental (maternal environment, developmental stage, and stress) factors that are essential for the emergence of addictive disease. Our faculty is also noteworthy for the breadth of the approaches they bring to addiction science; we have expertise in studying how several major abused drugs (i.e. opiates, cocaine, and other psychostimulants) impact neuronal function from the expression and behavior of single molecules to the performance of complex functional systems that regulate the behavior of rodents and humans. In addition to our talented faculty, this training grant will take advantage of the WCGS outstanding research environment, educational resources, and recruiting activities, particularly our history of attracting and training under-represented minorities as basic and clinical scientists. Particular strengths of the training grant include: 1) the experience of the Director and Co-Director in mentoring, teaching and drug abuse research; 2) the broad scope of multidisciplinary research training provided by the faculty; 3) extensive collaborations and co-mentoring between the faculty; and 4) the strong emphasis on “bench-to- bedside” translational research. Training grant faculty will be divided into three groups: 1) Major Sponsors: graduate student thesis mentors with NIDA mission supported research programs; 2) Training Sponsors: individuals with extensive experience in drug abuse research who will work closely with Major Sponsors and their trainees; and 3) Minor Sponsors: individuals with NIDA- mission interests who will collaborate with Major Sponsors and their trainees. Resource Cores comprised of training grant faculty from all three groups will be established to provide a platform for students to incorporate approaches from multiple laboratories into their PhD thesis work. Beyond the laboratory, a new course entitled “Addiction and Society” developed by a group of graduate students in consultation with faculty, as well as a Drug Abuse focused retreat and WCGS developed programs in grant-preparation, will provide students with important training experiences in teaching, grantsmanship, and networking that will be essential for their career development. These courses together with the existing coursework and curricula, symposia and lectures, as well as each students individual training plan, will provide a solid foundation for the development of independent basic and clinical scientists in drug abuse research.

抽象的： 了解遗传和环境因素如何影响药物使用和滥用可能对 预防成瘾和诊断，以及新型有效成瘾疗法的发展。 该申请计划在Weill中提供3个摄影训练插槽（〜2年，从第二年开始） 康奈尔大学研究生院（WCGS）神经科学和药理学计划旨在了解 该培训计划的独特功能是多样性 遗传学方面的教师专业知识（例如性别，单核苷酸多态性，基因剪接变异， 树突状/轴突翻译和表观遗传学）和环境（孕产妇环境，发育 阶段和压力）因素对累加疾病的出现至关重要。我们的教师也是 值得注意的是，他们为成瘾科学带来的方法的广度；我们有学习的专业知识 几种主要的滥用药物（即鸦片，可卡因和其他心理刺激剂）如何影响神经元 从单分子的表达和行为到复杂功能的性能的功能 调节啮齿动物和人类行为的系统。除了我们才华横溢的教师之外，这项培训 格兰特将利用WCG杰出的研究环境，教育资源和 招募活动，特别是我们吸引和培训不足的少数民族的历史 和临床科学家。培训赠款的特殊优势包括：1）董事的经验和 心理，教学和药物滥用研究的联合导演； 2）多学科的广泛范围 教师提供的研究培训； 3）教职员工之间的广泛合作和联合会； 4）非常重视“基准对床”翻译研究。培训赠款教师将是 分为三组：1）主要赞助商：NIDA任务的研究生论文导师支持 研究计划； 2）培训赞助商：在药物滥用研究方面拥有丰富经验的人 将与主要赞助商及其培训密切合作； 3）次要赞助商：NIDA-的个人 将与主要赞助商及其培训合作的任务兴趣。包括资源核心 将建立来自所有三个小组的培训赠款教师，为学生提供一个平台 将多个实验室的方法纳入其博士学位论文工作。除了实验室之外，一个新的 一群研究生开发的题为“成瘾与社会”的课程 教师以及以药物滥用为重点的务虚会，WCGS制定了赠款计划的计划，将 为学生提供教学，授予技巧和网络的重要培训经验 他们的职业发展至关重要。这些课程以及现有课程和课程， 研讨会和讲座以及每个学生个人培训计划，将为 在药物滥用研究中的独立基本和临床科学家的发展。