Dawn Phenomena: Lowering Impaired Fasting Glucose Levels with Exercise (LIFE)

黎明现象：通过运动降低受损的空腹血糖水平 (LIFE)

• 批准号: 9195090
• 负责人: JILL A KANALEY
• 金额: $ 36.39万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9195090
• 关键词: Acute; Attenuated; Beta Cell; C-Peptide; Cardiovascular Diseases; Cardiovascular system; Cell physiology; Chronic; Communication; Data; Development; Diabetes Mellitus; Diet; Dose; Exercise; Exhibits; Fasting; Future; Glucagon; Glucose; Glycogen; Glycosylated hemoglobin A; Hormonal; Hyperglycemia; Hyperlipidemia; Impaired fasting glycaemia; Impairment; Individual; Insulin; Insulin Resistance; Kidney Diseases; Link; Metabolic; Muscle; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathology; Patients; Peripheral; Pharmacological Treatment; Physicians; Physiological; Play; Reporting; Research; Role; Study Subject; Time; Walking; Weight; diabetic; experience; fasting glucose; glucose disposal; glucose metabolism; glucose production; glucose uptake; hyperglucagonemia; improved; insight; insulin secretion; insulin sensitivity; lifestyle intervention; mathematical model; novel; polypeptide C; public health relevance; response; therapeutic target; treadmill

 DESCRIPTION (provided by applicant): Morning hyperglycemia plays a role in the future development of insulin resistance and type 2 diabetes (T2D) and is associated with numerous microvascular and cardiovascular complications and renal disease. These augmented morning glucose levels are due to an elevated endogenous glucose production (EGP), as a result of a loss of coordination between glucose levels and insulin secretion, and possibly hyperglucagonemia during the overnight period. Exercise stimulates glucose uptake and increases insulin sensitivity acutely, and may be the best lifestyle intervention to minimize the nocturnal rise in glucose levels. Prescription of the timing of exercise relative to a meal and/or o the overnight period may be particularly critical for individuals that have impaired fasting glucos (IFG) levels. Surprisingly we know little about the overnight period when elevated EGP and the synchrony between glucose and c-peptide/glucagon levels becomes disturbed. This novel study will provide insight into the hormonal/metabolic milieu of a dinner meal, the evening and overnight period that occurs in non-obese, OB and OB+IFG individuals; it will also establish if the timing of exercise can attenuate nocturnal glucose elevations, and if this is associated with improved hormonal synchrony. This project will compare EGP, β-cell function and hormonal responses between morning and evening exercise on the postprandial and overnight period in obese individuals with/without IFG levels. Fifty-four subjects will be studied during the evening meal (EGP and β-cell function), postprandially and through the overnight period (1600-0700 h), allowing us to examine some of the potential mechanisms for the elevation in overnight glucose levels. This is the first study that will examine this issue from pre-dinner through the night whil previous studies have only examined chronically fasted individuals and this study will lay the groundwork for understanding the pathology of the predawn phenomena in OB+IFG individuals. These potentially translational findings may impact the efficiency of physician communication to patients concerning exercise. We are one of the few groups that study subjects through the overnight period and have the facilities and capability to do this research.

 描述（由适用提供）：早晨高血糖在胰岛素抵抗和2型糖尿病（T2D）的未来发展中起作用，并且与许多微血管和心血管并发症以及肾脏疾病有关。这些增强的早晨葡萄糖水平是由于内源性葡萄糖产生（EGP）升高，这是由于葡萄糖水平和胰岛素分泌之间的协调损失以及在过夜期间可能的高葡萄糖症。运动可以刺激葡萄糖摄取并急剧提高胰岛素敏感性，并且可能是最佳的生活方式干预措施，以最大程度地减少葡萄糖水平的夜间升高。相对于用餐和/或O的运动时间的处方对于那些损害空腹葡萄糖（IFG）水平的个体而言，过夜期可能特别重要。令人惊讶的是，当升高的EGP以及葡萄糖和C肽/胰高血糖素水平之间的同步时，我们对过夜时期一无所知。这项新颖的研究将为您的夜晚和过夜时期提供对夜间和过夜的餐饮环境的见解；它还将确定运动的时间是否可以减弱夜间葡萄糖升高，并且这是否与改善的激素同步有关。该项目将比较早晨，甚至在餐后和过夜期间的EGP，β细胞功能和荷尔蒙反应，其中有或没有IFG水平的肥胖个体。在晚餐期间（EGP和β细胞功能）将在早段和整个夜间（1600-0700 h）中研究54名受试者（EGP和β细胞功能），从而使我们能够检查一些潜在的机制，以在过夜的葡萄糖水平中升高。这是第一项研究，将研究从餐厅到夜晚的这个问题，而先前的研究仅研究了长期禁食的个体，这项研究将为理解OB+IFG个体中黎明现象的病理奠定基础。这些可能翻译的发现可能会影响患者在运动方面的身体沟通效率。我们是整个夜间研究对象的少数小组之一，并具有进行这项研究的设施和能力。