RACIAL DIFFERENCES IN REGIONAL FAT DISTRIBUTION IN WOMEN

女性区域脂肪分布的种族差异

基本信息

批准号：
2751214
负责人：
JILL A KANALEY
金额：
$ 7.7万
依托单位：
SYRACUSE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-02-01 至 2002-01-31
项目状态：
已结题

项目摘要

Cardiovascular disease, hypertension and diabetes are associated with increased adipose tissue, in particular, an increase in visceral adipose tissue. Surprisingly, however, recent research has reported that young black women have more total adipose tissue, but less visceral adipose tissue than white women. Paradoxically, black women have a higher incidence of obesity and are affected by obesity-related health problems more so than white women. Thus the relationship between abdominal obesity and health problems may not be as strong in the black population as it is in the white population. This would suggest there are other underlying causes. In postmenopausal women, one possible mechanism for the increased abdominal fat could be linked with endocrine changes. Changes in estrogen with menopause may directly or indirectly alter dehydroepiandrosterone (DHEA), growth hormone (GH) or insulin-like growth factor-1 (IGF-1) concentrations. These hormones have been linked with increased body fat (57, 59) and/or increased abdominal visceral adipose tissue (10). Abdominal visceral fat and these hormones have not been studied in either black or older individuals. In addition, estrogen replacement therapy (ERT) can potentially alter these relationships between adipose tissue, hormone concentrations and health complications. To address NIA research objective number 2, the purpose of this project is to determine if racial differences exist in the relationship between regional body fat distribution and resting hormone concentrations (DHEA, GH and IGF-1). Further we will establish if the relationship between the blood lipid profile and body fat distribution is dependent on race and estrogen replacement status. Sixty age-matched postmenopausal women (30 black and 30 white women (15 on ERT and 15 not on ERT)) will have visceral adipose tissue, hormone concentrations and blood lipid profiles measured. This project is one of the first attempts to look at visceral adipose tissue in older black women and attempt to establish if differences are associated with blood lipid profiles and to differences in resting hormone concentrations.

心血管疾病，高血压和糖尿病与特别是增加内脏脂肪的脂肪组织增加组织。但是，令人惊讶的是，最近的研究报道了年轻黑人妇女的总脂肪组织更多，但内脏脂肪较少组织比白人妇女。矛盾的是，黑人妇女的较高肥胖的发生率，受肥胖相关的健康问题的影响比白人妇女更重要。因此腹部之间的关系肥胖和健康问题在黑人人群中可能不那么强烈就像白人人口一样。这表明还有其他根本原因。在绝经后妇女中，一种可能的机制增加的腹部脂肪可能与内分泌变化有关。更年期雌激素的变化可能直接或间接改变脱氢表雄酮（DHEA），生长激素（GH）或胰岛素样生长因子1（IGF-1）浓度。这些激素已链接人体脂肪增加（57、59）和/或腹部内脏增加脂肪组织（10）。腹部内脏脂肪和这些激素尚未被黑人或年龄较大的人进行了研究。此外，雌激素替代疗法（ERT）可能会改变这些脂肪组织，激素浓度与健康之间的关系并发症。为了解决NIA研究目标2，目的这个项目的是确定种族差异是否存在区域脂肪分布与静息激素之间的关系浓度（DHEA，GH和IGF-1）。此外，我们将确定是否血脂谱与体内脂肪分布之间的关系取决于种族和雌激素替代状态。六十岁绝经后妇女（30名黑人和30名白人妇女（15岁，ERT和15个没有在ERT上）将具有内脏脂肪组织，激素浓度和测量的血脂谱。这个项目是第一个项目之一尝试查看老年黑人妇女的内脏脂肪组织和尝试确定差异是否与血脂有关特征和静息激素浓度的差异。