A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults

改善久坐老年人身体活动、睡眠和认知的个性化行为干预

• 批准号: 9313511
• 负责人: Junxin Li
• 金额: $ 9.24万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313511
• 关键词: Accelerometer; Achievement; Affect; Aging; Attention; Behavior Therapy; Biological Markers; C-reactive protein; Characteristics; Circadian Rhythms; Cognition; Cognitive; Complex; Control Groups; Dementia; Devices; Effectiveness; Elderly; Ensure; Exercise; Foundations; Future; Goals; Health; Heart Rate; Impaired cognition; Individual; Inflammatory; Interleukin-1 beta; Interleukin-6; Intervention; Intervention Studies; Learning; Longitudinal cohort; Mediating; Mentors; Mission; Napping; National Institute of Nursing Research; Outcome; Outcome Study; Participant; Pathway interactions; Phase; Physical Exercise; Physical activity; Pilot Projects; Preparation; Public Health; Randomized Controlled Trials; Reporting; Research Personnel; Retrospective Studies; Risk Factors; Serum; Short-Term Memory; Sleep; Structure; TNF gene; Technology; Testing; Time; Training; United States; Work; Wrist; base; behavior change; career; career development; cognitive function; cognitive performance; cohort; cytokine; exercise intervention; follow-up; healthy aging; improved; innovation; insight; laboratory experience; novel; older men; older women; physical conditioning; processing speed; prospective; prototype; sedentary; sedentary lifestyle; vigilance

PROJECT SUMMARY/ABSTRACT The proposed project aims to identify the optimal features of daytime napping and physical activity for cognition in older adults (K99) and examine the effects of an innovative, personalized behavioral intervention on promoting physical activity, healthy napping, sleep and cognitive function in sedentary older adults (R00). In the K99 phase, to ensure the successful completion of the R00 project and facilitate the achievement of my career development goals, I will follow an intensive training plan that incorporates courses, laboratory training, mentoring, and structured activities. In addition, a retrospective study will be conducted using two large longitudinal cohorts of older adults in the United States to examine the associations of daytime physical activity and nocturnal sleep with cognitive decline over 4-6 years. The K99 study will examine: 1) baseline associations of napping characteristics, physical activity and nocturnal sleep duration with cognition; 2) whether baseline napping, physical activity and nocturnal sleep duration predict cognitive decline at the 4-6 year follow-up; and 3) relationships between changes in physical activity and nocturnal sleep duration and changes in cognitive function at follow-up. Building off the K99, in the R00 phase, a randomized controlled trial will be conducted in older adults (without dementia) with both sedentary lifestyle and nocturnal sleep complaints to examine the effectiveness of a 24-week personalized behavioral intervention implemented with smartwatch technology on promoting physical activity, nocturnal sleep, and cognition compared against a control group; we have successfully tested this in a pilot study. Serum inflammatory biomarkers will be assessed to explore hypothesized mechanisms for associations among the study outcomes. In order to optimize outcomes at the subject level, a personalized physical activity plan will be calculated based on the individual’s characteristics, personal circadian rhythm at baseline, and the optimal characteristics of napping and physical activity that were identified in the K99 phase. The R00 study will examine: 1) whether the intervention increases participants’ non-nap period physical activity, optimizes napping duration, and enhances nocturnal sleep; 2) whether the intervention improves participants’ overall cognitive performance; 3) whether the relationship between the study intervention and cognitive performance is mediated by changes in physical activity, healthy nap duration, and nocturnal sleep duration; and 4) (exploratory aim) if the proposed intervention changes serum inflammatory biomarkers, including cytokines (IL-6, IL-1ß, TNF-α) and C-reactive protein, and whether these biomarkers relate to changes in physical activity, sleep, and cognitive function. Upon completion, this proposal will provide important insights on the optimal features of physical activity and napping for cognitive function. The proposed intervention may provide a novel way for older adults to optimize wellness and achieve active, healthy lives while aging, a key theme of the National Institute of Nursing Research in its mission to enhance public health. It will also build a strong foundation for my future career as an independent researcher.

项目摘要/摘要 拟议的项目旨在确定白天小睡和认知体育锻炼的最佳特征 在老年人（K99）中，并检查创新的个性化行为干预对 在久坐的老年人中促进体育锻炼，健康的小睡，睡眠和认知功能（R00）。 K99阶段，以确保成功完成R00项目并促进我的成就 职业发展目标，我将遵循一项密集的培训计划，该计划包括课程，实验室培训， 指导和结构化活动。此外，将使用两个大型研究进行回顾性研究 美国老年人的纵向人群检查白天体育锻炼的关联 和夜间睡眠，认知能力下降了4 - 6年。 K99研究将检查：1）基线关联 与认知的小睡特征，体育活动和夜间睡眠持续时间； 2）是否基线 小睡，体育锻炼和夜间睡眠持续时间可预测4 - 6年随访的认知能力下降； 3） 体育活动变化与夜间睡眠持续时间与认知变化之间的关系 随访时的功能。在R00阶段建立K99，将进行随机对照试验 老年人（无痴呆症）具有久坐的生活方式和夜间睡眠投诉，以检查 用智能手表技术实施的24周个性化行为干预的有效性 与对照组相比，促进体育活动，夜间睡眠和认知；我们有 在一项试点研究中成功测试了这一点。将评估血清炎症生物标志物以探索 假设的研究结果之间的关联机制。为了优化结果 主题一级，个性化的体育活动计划将根据个人的特征计算， 基线时的个人昼夜节律，以及小睡和体育锻炼的最佳特征 在K99阶段被鉴定。 R00研究将检查：1）干预是否增加 参与者的非NAP时期体育活动，优化午睡时间并增强夜间睡眠； 2） 干预是否可以改善参与者的整体认知表现； 3）是否关系 研究干预措施和认知表现之间是由体育锻炼变化，健康的 午睡持续时间和夜间睡眠持续时间； 4）（探索目的）如果拟议的干预措施发生了变化 血清炎性生物标志物，包括细胞因子（IL-6，IL-1ß，TNF-α）和C反应蛋白，以及是否是否存在 这些生物标志物与体育活动，睡眠和认知功能的变化有关。完成后，这个 提案将提供有关体育锻炼和小睡的最佳特征的重要见解 功能。拟议的干预可能为老年人优化健康和成就提供了一种新颖的方式 衰老时积极，健康的生活，这是美国国家护理研究所的关键主题 增强公共卫生。这也将为我作为独立研究人员的未来职业奠定坚实的基础。