The power of 40 Hz sound/music for older adults with mild cognitive impairment

40 Hz 声音/音乐对患有轻度认知障碍的老年人的力量

• 批准号: 10509893
• 负责人: Junxin Li
• 金额: $ 24.56万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10509893
• 关键词: Acoustic Stimulation; Acute; Adherence; Affect; Age; Alzheimer' s Disease; American; Amyloid beta-Protein; Animal Experimentation; Animals; Auditory; Auditory area; Back; Clinical; Cognition; Cognitive; Communities; Cross-Over Trials; Data; Development; Elderly; Electroencephalogram; Electroencephalography; Esthetics; Evaluation; Exposure to; Feasibility Studies; Frequencies; Future; Goals; Health; Hippocampus (Brain); Hour; Human; Impaired cognition; Individual; Intervention; Interview; Libraries; Measures; Music; Neurons; Parietal; Participant; Pathology; Persons; Procedures; Quality of life; Randomized; Research; Scalp structure; Stimulus; Structure; Time; Training; Translating; amnestic mild cognitive impairment; cognitive benefits; cognitive enhancement; cognitive function; cohort; computerized; density; experience; feasibility testing; high risk population; improved; innovation; mild cognitive impairment; mouse model; neural circuit; novel; prevent; primary outcome; relating to nervous system; slow potential; sound; spatial memory; tau Proteins

PROJECT SUMMARY/ABSTRACT There are limited treatment options for Alzheimer’s disease dementia (AD) and its associated progressive cognitive impairment, calling for target interventions that potentially slow the progression of cognitive decline, prevent, or delay the onset of AD in individuals with mild cognitive impairment (MCI). One promising treatment possibility is auditory stimulation at gamma frequencies. Emerging research suggests that 40 Hz sound may stimulate gamma oscillations and enhance cognitive function in older adults, but much remains unknown. Our group has created a novel 40 Hz music intervention, which may provide similar gamma entrainment, and is likely more aesthetically pleasing, allowing an evaluation of the long-term use of 40 Hz stimulation on cognitive function. We will conduct a 3-treatment 3-period pilot crossover trial to test the feasibility and preliminary efficacy of 40 Hz music (Condition A), 40 Hz sound (Condition B) and preferred music (Condition C) on neural gamma activity and cognitive function in 30 community-dwelling older adults with amnestic MCI. The participants will be randomized to three groups with different sequences of exposure to all three conditions. To examine the effect of the three conditions on gamma entrainment, participants will first undergo an acute music/sound stimulation session and a scalp electroencephalogram (EEG) will be recorded during the session. Next, the participants will be instructed to listen to the assigned sequence of conditions, with each condition for four weeks (1 h/day, 5 days/week). There will be a 10-day wash-out break between each condition. Semi- structured interviews will be conducted after completing each condition. The specific aims are as follows: Aim 1: Evaluate the feasibility of the study and the three conditions: 40 Hz music, 40 Hz sound, and Preferred Music in older adults with MCI. Qualitative data will be used to understand the participant's experience and acceptability of the three conditions; Aim 2: Determine the preliminary efficacy of 40 Hz music for four weeks on cognitive function compared with 40 Hz sound and Preferred Music; Aim 3: Evaluate the effect of 40 Hz music and 40 Hz sound on gamma entrainment during the acute stimulation session. This study will be the first to test the feasibility and preliminary efficacy of innovative 40 Hz music and 40 Hz sound interventions on cognitive function in older adults with MCI, a high-risk population for AD. Findings from this study will provide important evidence for future development, selection, evaluation, and implementation of music/sound interventions for cognitive health in older adults with MCI.

项目摘要/摘要 阿尔茨海默氏病痴呆症（AD）及其相关的进行性治疗方案有限 认知障碍，要求采取目标干预措施，这些干预措施可能会减慢认知能力下降的进展， 预防或延迟患有轻度认知障碍的个体（MCI）的AD发作。一种承诺治疗 可能性是伽马频率下的听觉刺激。新兴研究表明40 Hz声音可能 刺激伽马振荡并增强老年人的认知功能，但仍然未知。我们的 Group创建了一种新颖的40 Hz音乐干预措施，可能会提供类似的伽玛启蒙运动，并且是 在美学上可能更令人愉悦，可以评估40 Hz刺激对认知的长期使用 功能。我们将进行3次治疗3周期试验跨界试验，以测试可行性和初步 40 Hz音乐的功效（条件A），40 Hz声音（条件B）和首选音乐（条件C）神经元 30名居住在社区的老年人的伽马活性和认知功能。这 参与者将被随机分为三组，这些序列在所有三个条件下都有不同的暴露序列。到 检查三个条件对伽马启蒙的影响，参与者将首先发生急性 音乐/声音刺激会议和头皮脑电图（EEG）将在会议期间记录。 接下来，将指示参与者聆听分配的条件顺序，每种条件 四个星期（1小时/天，5天/周）。每种条件之间将有10天的冲洗断裂。半- 完成每种条件后，将进行结构化访谈。具体目的如下：目标 1：评估研究的可行性和三个条件：40 Hz音乐，40 Hz声音，首选 MCI的老年人音乐。定性数据将用于了解参与者的经验和 这三个条件的可接受性；目标2：确定40 Hz音乐的初步效率四个星期 关于认知功能，与40 Hz声音和首选音乐相比；目标3：评估40 Hz的效果 急性刺激会议期间，音乐和40 Hz的声音。这项研究将是第一个 测试创新40 Hz音乐和40 Hz声音干预的可行性和初步效果 MCI的老年人的认知功能，AD的高危人群。这项研究的发现将提供 音乐/声音的未来发展，选择，评估和实施的重要证据 MCI老年人认知健康的干预措施。