Adolescent Controlled Text Messaging to Improve Asthma Medication Adherence in Pr

青少年控制短信以提高预防哮喘药物的依从性

• 批准号: 8568276
• 负责人: MARIA T BRITTO
• 金额: $ 18.21万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8568276
• 关键词: Address; Adherence; Adolescent; Adrenal Cortex Hormones; Affect; Asthma; Behavior; Behavior Therapy; Breathing; Calendar; Caring; Child; Childhood; Chronic; Clinic; Clinical; Clinical Research; Data; Development; Dose; Economic Burden; Effectiveness; Electronics; Future; Goals; Health Care Costs; Hospitalization; Intervention; Lead; Low income; Measures; Minority; Monitor; Morbidity - disease rate; Motivation; Outcome; Participant; Patient Self-Report; Patients; Pharmaceutical Preparations; Pilot Projects; Population; Prevalence; Preventive; Primary Health Care; Procedures; Provider; Quality of life; Randomized Controlled Trials; Records; Recruitment Activity; Research; Research Personnel; Schools; Severities; Site; System; Teenagers; Text; Time; Treatment Efficacy; Visit; Work; adverse outcome; base; behavior change; cost; design; effective intervention; forgetting; health economics; high risk; improved; innovation; medication compliance; member; mortality; novel; primary care setting; public health relevance; randomized trial; satisfaction; skills; tool; treatment adherence; usability

DESCRIPTION (provided by applicant): Asthma, the most common chronic condition of childhood, currently affects millions of adolescents. The rates, severity and adverse outcomes for those in poor minority populations are higher. One reason for this is the lack of adherence to medication among these adolescents. This team has developed a novel, developmentally appropriate, adolescent controlled, calendar-to-text messaging intervention suitable for use in primary care to improve adherence by promoting autonomy and control and prompting use of controller medications for these adolescents. We propose to conduct a pilot randomized controlled trial, in four Cincinnati Childrens based primary care clinics, of a texting interventio to increase adherence to preventive asthma medication among this poor minority population. We will achieve this objective though three specific aims: Aim 1: To determine the feasibility, acceptability, and use of a low intensity text messaging intervention to improve adherence to inhaled corticosteroid (ICS) therapy among high risk adolescents with persistent asthma recruited from 4 primary care practice sites. Aim 2: To determine effect sizes of the intervention to improve adherence (as measured by electronic monitoring and self report); clinical asthma control; and asthma related quality of life among adolescents with persistent asthma. Aim 3: To determine the temporal relationship between text message receipt and ICS canister actuation in order to understand mechanisms by which text messaging may increase ICS adherence. This research team is ideally suited to conduct this innovative trial. The senior investigators have worked together previously, including development of the preliminary data for this application. Our four primary care clinics also have an excellent track record of successful recruitment for clinical studies and a large number of adolescent patients with persistent asthma. Through this research, we will gather data on feasibility, usability and efficacy of the intervention that will ead to a future R01 application to examine the intervention's efficacy in a fully powered randomized trial.

描述（由申请人提供）：哮喘是儿童时期最常见的慢性疾病，目前影响着数百万青少年。贫困少数民族人口的发病率、严重程度和不良后果更高。造成这种情况的原因之一是这些青少年缺乏服药依从性。该团队开发了一种新颖的、适合发育的、青少年控制的、日历到短信的干预措施，适用于初级保健，通过促进自主性和控制以及提示这些青少年使用控制药物来提高依从性。我们建议在辛辛那提儿童的四个初级保健诊所进行一项随机对照试验，通过短信干预来提高贫困少数群体对预防性哮喘药物的依从性。我们将通过三个具体目标来实现这一目标： 目标 1：确定低强度短信干预的可行性、可接受性和使用情况，以提高从 4 个主要地区招募的患有持续性哮喘的高危青少年对吸入皮质类固醇 (ICS) 治疗的依从性护理实践场所。目标 2：确定提高依从性的干预措施的效果大小（通过电子监控和自我报告衡量）；临床哮喘控制；患有持续性哮喘的青少年的生活质量与哮喘相关。目标 3：确定短信接收和 ICS 罐启动之间的时间关系，以便了解短信可提高 ICS 依从性的机制。 该研究团队非常适合进行这项创新试验。高级研究人员之前曾合作过，包括开发该应用的初步数据。我们的四个初级保健诊所在成功招募临床研究和大量患有持续性哮喘的青少年患者方面也拥有良好的记录。 通过这项研究，我们将收集有关干预措施的可行性、可用性和功效的数据，这些数据将有助于未来的 R01 应用，以在全面随机试验中检查干预措施的功效。