Core C- Molecular Regulation of Stem Cell Aging, Bioinformatics Core

核心C-干细胞衰老的分子调控，生物信息学核心

• 批准号: 9211410
• 负责人: Charles Yang Lin
• 金额: $ 14.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9211410
• 关键词: Address; Aging; Bioinformatics; Cell Aging; Cell Count; Chromatin; Code; Collaborations; Communities; Computer Analysis; Computer software; Custom; DNA Methylation; DNA Sequencing Facility; Dana-Farber Cancer Institute; Data; Data Analyses; Data Quality; Data Security; Data Set; Data Storage and Retrieval; Databases; Descriptor; Development; Ensure; Environment; Epigenetic Process; Face; Gene Expression; Genetic Transcription; Genome; Genomics; Goals; Hybrids; Imagery; Individual; Institutes; Institution; Language; Lead; Link; Maps; Medicine; Molecular; Online Systems; Play; Process; Publishing; Pythons; Regulation; Repetitive Sequence; Reproducibility; Research; Research Personnel; Resources; Role; Secure; Security; Software Engineering; Standardization; Stem cells; System; Techniques; United States National Institutes of Health; Universities; age related; application programming interface; base; college; computerized data processing; data sharing; data visualization; epigenetic regulation; epigenome; high dimensionality; improved; innovation; interoperability; next generation sequencing; novel; novel strategies; open source; power analysis; programs; single molecule; software development; tool

SUMMARY There is a shared need for genomic and other high dimensional data analysis among project investigators. The Bioinformatics Core will establish a centralized, intelligent and robust computational platform for high dimensional data analysis powered by a well-developed open source software code base that will integrate novel techniques to more quantitatively map chromatin and epigenetic changes during aging. To accelerate the computational aims of this Program Project, the Core will lead a collaborative endeavor 1) to improve data accessibility and security by implementing a NIH and GEO compliant database solution, 2) to promote bioinformatics collaboration and reproducibility by implementing an application programming interface (API) that interconnects analysis software and establishes a shared and well documented development and analysis language, and 3) to enable facile data exploration and interpretation by creating web based portals for project specific data analysis and visualization. Through these Aims, this central resource for the Molecular Regulation of Stem Cell Aging Program Project will promote intra-lab interactions and coordinate high dimensional data analysis to help meet the broader goals of better understanding the epigenetic regulation of aging in stem cells.

概括 在项目之间共同需要基因组和其他高维数据分析 调查人员。生物信息学核心将建立一个集中式，聪明和健壮的 高维数据分析的计算平台，该平台由发达的开放式启动 源软件代码库，该代码将集成新技术以进行更定量的映射 老化期间的染色质和表观遗传变化。加快计算目标 计划项目，核心将领导协作努力1）改善数据可访问性和 通过实施NIH和GEO符合GEO的数据库解决方案的安全性，2）促进 通过实施应用程序编程，生物信息学协作和可重复性 互连分析软件并建立共享且很好的接口（API） 记录了开发和分析语言，以及3）启用便利数据探索和 通过创建基于Web的门户来解释项目特定的数据分析和可视化。 通过这些目的，这种用于干细胞衰老的分子调节的中心资源 计划项目将促进LAB内相互作用并协调高维数据 分析有助于实现更好地理解表观遗传调节的更广泛的目标 干细胞衰老。