Development of a pedigreed baboon genome resource for biomedical research

开发用于生物医学研究的纯种狒狒基因组资源

基本信息

批准号：
9114687
负责人：
Laura A Cox
金额：
$ 80.46万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9114687
关键词：
Address Animal Model Behavioral Biomedical Research Bone Density Chromosome Mapping Communities Complement Complex Controlled Environment Custom Data Databases Development Diabetes Mellitus Diet Disease Disease susceptibility Future Gene Frequency Generations Genetic Genetic Polymorphism Genetic Recombination Genetic Research Genetic study Genome Genomics Genotype Haplotypes Health Housing Human Human Biology Human Gene Mapping Human Genetics Hypertension Individual Lead Libraries Linkage Disequilibrium Maps Minor Modeling Molecular Genetics National Human Genome Research Institute Obesity Osteoporosis Papio Papio hamadryas Phenotype Physical Chromosome Mapping Population Primates Reproductive Endocrinology Research Resolution Resources Sampling Single Nucleotide Polymorphism Time Variant base computer design design exome genetic pedigree genetic technology genome sequencing genomic tools human disease improved scaffold trait whole genome

项目摘要

DESCRIPTION (provided by applicant): Baboons are an important biomedical model for many complex traits, including athlerosclerosis, bone density and obesity. With short generation times and an ability to control the environment, baboons provide a natural complement to human genetic studies of complex traits. However, high-resolution genetic studies in baboons are hampered by a lack of genomic resources. We will address this gap by improving the quality of the baboon genome assembly, providing comprehensive maps of common polymorphisms and haplotypes across the baboon genome, and constructing a high-resolution genetic map for baboons. Together, these resources will enable future fine-scale genotype-phenotype studies in baboons, which in turn may lead to important biomedical advances in understanding the genetic basis of human disease.

描述（由申请人提供）：狒狒是许多复杂特征的重要生物医学模型，包括动脉粥样硬化、骨密度和肥胖。狒狒的世代时间短且具有控制环境的能力，为人类复杂性状的遗传学研究提供了天然的补充。然而，狒狒的高分辨率遗传学研究因缺乏基因组资源而受到阻碍。我们将通过提高狒狒基因组组装的质量、提供狒狒基因组常见多态性和单倍型的综合图谱以及构建狒狒高分辨率遗传图谱来解决这一差距。总之，这些资源将使未来对狒狒进行精细基因型-表型研究成为可能，这反过来可能会在了解人类疾病的遗传基础方面带来重要的生物医学进展。