The impact of stress on steroid hormones and cue reactivity in smokers and gamblers

压力对吸烟者和赌徒的类固醇激素和提示反应的影响

基本信息

批准号：
9001811
负责人：
Stephanie Wemm
金额：
$ 1.69万
依托单位：
STATE UNIVERSITY OF NEW YORK AT ALBANY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9001811
关键词：
Abstinence Acute Addictive Behavior Adrenal Glands Affect Alcohol or Other Drugs use Arousal Attention Behavioral Biological Process Cigarette Smoker Control Groups Cues Enzyme Immunoassay Exposure to FDA approved Feeling Galvanic Skin Response Gambling Heart Rate Hormonal Hormones Hydrocortisone Inorganic Sulfates Investigation Knowledge Lead Learning Link Liquid Chromatography Literature Measures Mental Depression Methods Motivation Nature Neurobiology Nicotine Dependence Participant Patient Self-Report Pattern Personal Satisfaction Physiological Physiology Post-Traumatic Stress Disorders Procedures Process Property Reaction Relapse Reporting Research Salivary Sampling Severities Smoke Smoker Smoking Societies Steroids Stress Substance Addiction Substance Use Disorder Symptoms Time Unspecified or Sulfate Ion Sulfates Visual acute stress addiction adverse outcome analog base biological adaptation to stress biopsychosocial cigarette smoking cost craving cue reactivity dehydroepiandrosterone heart rate monitor insight interest negative affect potential biomarker psychologic public health relevance response social steroid hormone stress reactivity stressor tandem mass spectrometry

项目摘要

DESCRIPTION (provided by applicant): Addictions, both substance and behavioral, have been conceptualized as having common biopsychosocial processes with different opportunistic expressions (Shaffer et al., 2004). Traditionally, substance use disorders have received significant attention in the literature due to presumed inherently addictive nature of the substance. In contrast, research has focused much less on behaviorally based addictions, such as gambling. Biological processes such as the hormonal response to stress, measured by cortisol, dehydroepiandrosterone (DHEA), and the ratio of the cortisol/DHEA, may underlie the disposition to develop an addictive disorder, regardless of whether it is a substance-based or a so-called behavioral addiction. The proposed study will be conducted with heavy smokers, problem scratch-off gamblers, and healthy controls to investigate the effect of an acute social stressor on reactivity to smoking or gambling cues. Subjective (urges, cravings) and physiological responses (skin conductance and heart rate) will be measured in response to smoking or gambling cues versus neutral cues, once under normal conditions and again after exposure a social stressor. Stress hormones (salivary cortisol and DHEA) will be measured repeatedly during the procedures. It is hypothesized that cigarette smokers and problem gamblers will display a similar cortisol response to the acute stressor in comparison to the control group. In addition, heavy smokers and problem gamblers will display similarly blunted cortisol responses to an acute stressor. In addition, cue reactivity in smokers and gamblers will increase following a stressor compared to non-stressed cue exposure. Finally, it is hypothesized that a higher baseline cortisol/DHEA ratio will predict higher subjective and physiological arousal to active cues and be associated with increased symptoms and more adverse consequences of addiction.

描述（由适用提供）：物质和行为的成瘾已被概念化为具有具有不同机会性表达的常见生物心理社会过程（Shaffer等，2004）。传统上，由于物质的固有性质，物质使用障碍在文献中受到了极大的关注。相比之下，研究的重点少于基于行为的成瘾，例如赌博。通过皮质醇，脱氢表甲酮（DHEA）和皮质醇/DHEA的比率测量的生物学过程，例如对压力的反应，无论是基于药物还是所谓的行为成瘾。拟议的研究将与大量吸烟者，问题刮擦赌徒和健康控制者一起进行，以研究急性社会压力源对吸烟或赌博提示的反应性的影响。吸烟或赌博提示。主观（冲动，渴望）和身体反应（皮肤电导和心率）将以响应吸烟或赌博提示与中性线索的反应来衡量，一次在正常情况下，在暴露后再次接触社会压力。在手术过程中，将反复测量应力马（唾液皮质醇和DHEA）。假设吸烟者和问题赌博将与对照组相比，与急性应激源显示出类似的皮质醇反应。此外，大烟和赌徒的大量吸烟者将对急性压力源的皮质醇反应类似。此外，与无应激的提示暴露相比，在压力源后，吸烟者和赌徒的提示反应性将增加。最后，假设较高的基线皮质醇/DHEA比将预测更高的主观和物理唤醒主动提示，并与成瘾的符号增加和更不利的后果有关。