Alteration and Renovation

改建和翻新

• 批准号: 8812380
• 负责人: THOMAS EDWARD PRISINZANO
• 金额: $ 9.28万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8812380
• 关键词: Biological; Biological Assay; Biology; Chemicals; Communicable Diseases; Containment; Equipment; Funding; Housing; Infectious Agent; Kansas; Laboratories; Location; Research; Screening procedure; Time; Universities; Validation; assay development; hazard; high throughput screening; screening; small molecule libraries; square foot; structural biology

Project Summary Effective and efficient high-throughput screening (HTS) of large chemical libraries requires many carefully coordinated efforts that span target selection through assay validation and into automated large-scale screening. Additionally, assay development and performing high-throughput screening for infectious disease targets can often require special consideration and conditions due to biological hazard and containment issues. To provide for these special considerations and minimize the impact of infectious agents on the general activities of the HTS facility and associated equipment, we propose to renovate space adjacent to the high- throughput screening facility such that it is suitable for performing infectious disease assay development and limited chemical screening associated with Core B. The proposed renovations would provide 211 sq ft of laboratory space dedicated for infectious disease assay development and many high-throughput screening procedures. The proposed laboratory would be suitably equipped through direct contributions from the University of Kansas. Timing for renovations to be completed are estimated to be within six months after receipt of funds.

项目摘要 大型化学文库的有效高效的高通量筛选（HTS）需要许多仔细的 通过测定验证并自动化大规模的协调努力，这些努力跨越目标选择 筛选。此外，测定开发和进行传染病的高通量筛查 由于生物危害和遏制问题，目标通常需要特殊考虑和条件。 提供这些特殊注意事项，并最大程度地减少传染剂对一般的影响 HTS设施和相关设备的活动，我们建议翻新与高高相邻的空间 吞吐量筛查设施使其适合进行传染病测定开发和 与核心B相关的有限化学筛查。拟议的翻新将提供211平方英尺的 专门用于传染病测定开发和许多高通量筛查的实验室空间 程序。拟议的实验室将通过直接捐款来适应 堪萨斯大学。估计要完成翻新的时间估计在六个月之内 收到资金。