Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome

脆性 X 综合征焦虑的出现、稳定性和预测因素

基本信息

批准号：
9176148
负责人：
Jane E Roberts
金额：
$ 74.08万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9176148
关键词：
3 year old 5 year old Address Adolescent Adult Age Anxiety Anxiety Disorders Attention deficit hyperactivity disorder Behavioral Biological Biological Markers Child Child Rearing Clinical Cognition Comorbidity Complement Cross Syndrome Development Diagnosis Diagnostic Early Intervention Early identification Early treatment Environmental Risk Factor Etiology Eye FMR1 Fragile X Syndrome Genetic Heart Heterogeneity High Prevalence Hydrocortisone Impairment Individual Intellectual functioning disability Intervention Language Measurement Medical Medical Genetics Mental Health Mental disorders Methylation Modeling Mood Disorders Nursery Schools Outcome Persons Physiological Population Prevalence Prevalence Study Prevention Public Health Quality of life Recording of previous events Research Risk Severities Social Behavior Specificity Stress Subgroup Symptoms Time Work anxiety symptoms autism spectrum disorder behavior rating scale boys comparison group critical developmental period functional outcomes high risk improved improved functioning interest male maternal anxiety meetings prognostic value prospective risk sharing

项目摘要

ABSTRACT Given the high prevalence and substantial impact of mental illness on individuals with intellectual disabilities (ID) studies that examine mental health in persons with ID are critical to direct treatment aimed at reduction and, more importantly, prevention of mental illness to improve functioning and quality of life. Fragile X syndrome (FXS) is the leading identified cause of ID with up to 80% of adolescents and adults with FXS meeting criteria for an anxiety disorder. FXS is an ideal model to investigate the combined and interactive effects among biological, behavioral and environmental factors on the emerging trajectory of anxiety in persons with ID. This application “Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome” proposes the first longitudinal prospective developmental study of the early features of anxiety in very young boys with FXS contrasted to boys diagnosed with ASD (non-FXS) and typical controls (TD). We are interested in the age at which initial features of anxiety can be detected and the stability and prognostic value of these early symptoms to diagnostic categorization across two populations associated with ID and at high risk for anxiety. Likewise, we are interested in documenting factors that predict the emergence, stability and severity of anxiety in these two populations.

抽象的鉴于精神疾病对智障人士的高流行和重大影响（ID）研究患有ID的人的心理健康的研究对于直接旨在减少治疗至关重要而且，更重要的是，预防精神疾病以改善功能和生活质量。脆弱的x 综合征（FXS）是ID的主要原因，高达80％的青少年和FX的成年人满足焦虑症的标准。 FXS是研究组合和交互式的理想模型生物学，行为和环境因素对人的新兴动画轨迹的影响使用ID。该应用“脆弱X综合征中焦虑的出现，稳定性和预测指标”提出 FXS非常小男孩的动画早期特征的首次纵向前瞻性发展研究与被诊断为ASD（非FXS）和典型对照（TD）的男孩形成鲜明对比。我们对年龄感兴趣可以检测到动画的最初特征以及这些早期症状的稳定性和预后价值与ID相关的两个人群和动画风险高的诊断类别。同样，我们是有兴趣记录预测这两个动画的出现，稳定性和严重性的因素人群。