Animal Research Infrastructure Improvements

动物研究基础设施的改善

• 批准号: 9324761
• 负责人: Kristin Nicole Grimsrud
• 金额: $ 41.38万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9324761
• 关键词: Advocate; Aging; Air; Allergens; Animal Experimentation; Animal Housing; Animal Sources; Animals; Area; Biological Preservation; Biology; Biomedical Research; Breeding; CRISPR/Cas technology; California; Chimera organism; Communities; Complex; Containment; Country; Cryopreservation; Delaware; Education; Embryo; Embryo Transfer; Environment; Equipment; Exclusion; Fertilization in Vitro; Funding; Goals; Health; Human Resources; Institution; Laboratory Animal Production and Facilities; Laboratory Animals; Lead; Learning; Methods; Modeling; Modernization; Mus; Mutant Strains Mice; Noise; One-Step dentin bonding system; Phase; Procedures; Process; Production; Request for Proposals; Research; Research Infrastructure; Resources; Risk; Rodent; Science; Services; Source; Standardization; Sterility; Stress; Technology; Thinness; Time; United States National Institutes of Health; Universities; Water; Water Supply; Water consumption; aged; animal care; collaborative environment; cost; design; ergonomics; genome editing; improved; innovation; mouse model; mutant mouse model; operation; pathogen; pathogen exposure; programs; prototype; repository; sperm cell; success; transmission process; vibration; water conservation

Abstract To better support the needs of our aging vivarium, the Mutant Mouse Resource and Research Center at the University of California, Davis (MMRRC-UCD) is driven to improve the infrastructure and equipment within our M3 high-level rodent barrier facility. As a premier distributor of mutant mouse models, the infrastructure of our barrier is a critical factor influencing the health and well-being of the animals we produce and distribute worldwide, currently serving 41 countries. The MMRRC-UCD is the largest center of the four NIH-funded consortiums, and specializes in the cryopreservation and distribution of valuable mutant mouse models. In continued efforts to improve the efficiencies of our operations we have analyzed the deficiencies hindering our optimal production and identified a key factor being aged and outdated equipment. Older animal housing and procedure equipment can lead to increased energy and water use, in addition to excessive noise and vibrations compared to more advanced modernized technologies, all leading to increase stress to the animal. As a result, animal production may be compromised and the costs of operations increased. The laboratory animal community has been strong advocates to promote the “3R’s” being Replacement, Reduction and Refinement. However, we are now in an era when we must also advocate for what we envision as the “5E’s”: Efficiencies, Exclusion, Ergonomics, Enrichment, and Education. Our goal is to improve the infrastructure at our barrier facility by implementing lean management principles with an environmentally resourceful emphasis using our innovative 5E’s approach. The current proposal requests funds to upgrade outdated animal transfer stations and biosafety cabinet in the M3 Barrier Facility. Additionally, we will discontinue the use of water bottles as a water source for the animals and convert to using HydropacTM pouches to provide a sterile water source, thus reducing the risk of pathogens and decreasing the environmental resources used. The MMRRC- UCD strives to advantageously integrate innovative concepts for higher efficient, exclusive and ergonomic vivarium designs to transform our standard rodent barrier facility into a state of the art prototype of a Lean- Green animal research facility, to guild other institutions to enable our principles to be applied globally.

抽象的 为了更好地满足我们老化动物园的需求，突变小鼠资源和研究中心 加州大学戴维斯分校 (MMRRC-UCD) 致力于改善我们的基础设施和设备 M3 高级啮齿动物屏障设施作为突变小鼠模型的主要经销商，我们的基础设施。 屏障是影响我们生产和分销的动物健康和福祉的关键因素 MMRRC-UCD 是 NIH 资助的四个中心中最大的一个，目前服务于全球 41 个国家。 联盟，专门从事有价值的突变小鼠模型的冷冻保存和分销。 为了持续提高我们的运营效率，我们分析了阻碍我们运营的缺陷 最佳生产并确定了老化和过时的设备和陈旧的关键因素。 程序设备除了过度的噪音和噪音外，还会导致能源和水的使用增加。 与更先进的现代化技术相比，振动会增加动物的压力。 因此，动物生产可能会受到影响，实验室的运营成本也会增加。 动物界一直大力倡导“3R”，即替代（Replacement）、减少（Reduction）和 然而，我们现在所处的时代还必须倡导我们所设想的“5E”： 效率、排斥性、人体工程学、丰富性和教育是我们的目标。 我们的屏障设施实施精益管理原则，注重环境资源 使用我们创新的 5E 方法 当前提案要求提供资金来升级过时的动物转移。 M3 屏障设施中的站和生物安全柜 此外，我们将停止使用水。 瓶子作为动物的水源，并转换为使用 HydropacTM 袋来提供无菌水 源，从而降低病原体风险并减少环境资源的使用。 UCD 致力于有利地整合创新概念，以实现更高的效率、独特性和人体工程学 动物园设计将我们的标准啮齿动物屏障设施转变为最先进的精益原型 绿色动物研究设施，指导其他机构使我们的原则在全球得到应用。