Biometry

生物测定

• 批准号: 8378077
• 负责人: Chengcheng Hu
• 金额: $ 19.25万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8378077
• 关键词: Accounting; Address; Biometry; Chemoprevention; Clinical; Clinical Trials; Collaborations; Computers; Data Collection; Data Quality; Databases; Decision Trees; Development; Epidemiology; Goals; Human; Human Resources; Individual; Information Storage and Retrieval; Instruction; Laboratories; Link; Manuscripts; Methods; Phase; Population; Preclinical Testing; Preparation; Procedures; Process; Program Research Project Grants; Publications; Quality Control; Reporting; Research Design; Research Personnel; Resources; Risk; Sample Size; Skin Cancer; Statistical Methods; Translational Research; Work; Writing; data management; design; innovation; mouse model; programs

PROJECT SUMMARY (See instructions): The goal of the Chemoprevention of Skin Cancer (CSC) Biometry Core is to collaborate with all investigators in development and application of statistical methocis for design, conduct and analysis of all projects, including data management and computing support, This goal is achieved through the following specific aims: 1, To provide statistical and epidemiological collaboration in the design and execution of all projects. 2, To develop procedures for data collection, and build and maintain computer databases for information storage and retrieval. 3, To provide interim reports on individual study progress. 4, To provide statistical analysis and participate in writing manuscripts for publication. 5, To provide an administrative link between Core D and Project 3 in terms of managing and accounting for study agents. Biometry support is required in all phases of program studies, At the design phase, the core staff addresses statistical design, analysis methocis, power and sample size issues, and works with other investigators to establish data management and quality control procedures. They then participate in the management, oversight and interim reporting of ongoing studies. Upon study completion, core personnel perform statistical analyses in collaboration with other investigators and participate in preparation of manuscripts for publication. As a unique expertise, the core provides support in the design and analysis of studies involving karyometric endpoints. The Biometry Core continues to be used by all investigators in both clinical and laboratory settings. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions ofthe decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.

项目摘要（参见说明）： 皮肤癌化学预防（CSC）生物测定核心的目标是与所有研究人员合作开发和应用统计方法来设计、实施和分析所有项目，包括数据管理和计算支持，这一目标已实现 通过以下具体目标： 1、在所有项目的设计和执行中提供统计和流行病学协作。 2、开发数据收集程序，建立和维护用于信息存储和检索的计算机数据库。 3、提供个人学习进度的中期报告。 4、提供统计分析并参与撰写发表稿件。 5、在研究代理的管理和会计方面提供核心D和项目3之间的行政联系。 项目研究的所有阶段都需要生物统计支持。在设计阶段，核心人员解决统计设计、分析方法、功效和样本量问题，并与其他研究人员合作建立数据管理和质量控制程序。然后他们参与正在进行的研究的管理、监督和临时报告。研究完成后，核心人员与其他研究人员合作进行统计分析，并参与准备出版手稿。作为独特的专业知识，核心 为涉及核测量终点的研究的设计和分析提供支持。生物测定核心继续被临床和实验室环境中的所有研究人员使用。 这个高度互动和临床转化的研究计划项目侧重于在创新小鼠模型中成功进行靶向化学预防药物的临床前测试（项目1和2），然后在高危人群中设计和实施临床试验（项目3）。决策树选择过程以及项目和核心之间的交互的详细描述可以在资源格式页面上找到。