Training OPportunities in Translational Imaging Education and Research (TOP-TIER)

转化成像教育和研究的培训机会（顶级）

• 批准号: 9279570
• 负责人: Samuel Achilefu
• 金额: $ 14.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-07 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9279570
• 关键词: Image; education research; training opportunity

PROJECT SUMMARY Precision medicine is emerging as an approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. While some limited advances in precision medicine have been made in the field of oncology, precision medicine is not in broad practice. Precision medicine has become an initiative of the National Institutes of Health (NIH) and its partners. Development of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be needed to move forward this new NIH initiative. A trained physician-scientist workforce is key to taking advantage of these new developments. Precision imaging advances are interdisciplinary with technology innovations crossing the physical, computational, and biological sciences. These studies start with preclinical mechanistic inquiries using targeted pathology-based imaging and then expand into human subjects. Human studies include safety testing and the Food and Drug Administration's (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate goal is to make research innovations widely available to the public and the entire practicing medical community through commercialization. Although this “bench-to-bedside” process has been widely acclaimed, there remains a knowledge gap in the medical imaging research community as to how to take preclinical research into humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and fellows – often lack the understanding to navigate research regulatory requirements as well as the knowledge base to understand or perform preclinical research that will inform the mechanism of innovation. A completely new educational and creative paradigm is required to better prepare future imaging scientists for the challenges of the NIH Precision Medicine Initiative. Interdisciplinary teams of physician-scientists must work together at the interfaces of biology, technology, and medicine, and physicians must be educated to work to bring innovation through the FDA regulatory processes, into human subjects and to the public through commercialization. In this application, we propose a model of education unlike any other for resident and fellow physician-scientists that will provide them with a two-year training program consisting of a) a required curriculum (year 1) that covers not only training in the ethics, regulatory and practical aspects of imaging research, but also a skill set for innovation translation, and b) dedicated translational imaging research (year 2) under the mentorship of highly-accomplished imaging pre-clinical and clinician scientists. With these needs and goals in mind, we are proposing TOP-TIER (Training OPportunities in Translational Imaging Education and Research), a clinician-scientist post-doctoral training program at Washington University (WU) in St. Louis to prepare resident and fellow trainees to bring preclinical imaging innovations into patients and to the practice of medicine.

项目摘要 精密医学正在成为一种疾病治疗和预防方法 说明基因，环境和生活方式的个人变异性。虽然精确的进步有限 在肿瘤学领域已经制作了医学，精确医学并非广泛实践。精确 医学已成为美国国立卫生研究院（NIH）及其合作伙伴的倡议。发展 特异性生物标志物成像的方法指导和监测患者特异性疗法的方法 需要继续这项新的NIH计划。训练有素的身体科学家劳动力是服用的关键 这些新发展的优势。精确成像的进步与技术跨学科 跨越物理，计算和生物科学的创新。这些研究以 使用基于病理的成像进行临床前机械询问，然后扩展到人 主题。人类研究包括安全测试和食品和药物管理局（FDA） 研究新药（IND）和设备豁免（IDE）过程。最终目标是进行研究 通过 商业化。尽管这个“基于床边”的过程已广受赞誉，但仍有一个 医学成像研究界的知识差距如何将临床前研究进行 人类，以及如何将这些创新带给公众。此外，临床科学家 - 居民和 研究员 - 通常缺乏对研究监管要求以及 了解或执行临床前研究的知识基础，这将为创新机制提供信息。 需要一个全新的教育和创意范式来更好地准备未来的成像科学家 对于NIH Precision Medicine Initiative的挑战。身体科学家的跨学科团队 必须在生物学，技术和医学的界面上一起工作，并且医生必须是 受过教育，以通过FDA监管过程，人类受试者和 通过商业化公众。在此应用程序中，我们提出了一种教育模型 对于居民和身体科学家，将为他们提供为期两年的培训计划 a）必需的课程（1年级），不仅涵盖伦理，监管和实用的培训 成像研究的各个方面，也是创新翻译的技能，b）专用翻译 成像研究（第2年）在高度逐渐绘制的临床前和临床的指导下 科学家。考虑到这些需求和目标，我们正在提议顶级（培训机会 翻译成像教育和研究），一项临床科学家的博士后培训计划 圣路易斯的华盛顿大学（WU）准备居民和同胞学员带来临床前成像 对患者和医学实践的创新。