Asbestos fate, exposure, remediation, and adverse health effects

石棉的归宿、接触、修复和不良健康影响

• 批准号: 9530878
• 负责人: Ian Alexander Blair
• 金额: $ 4.95万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9530878
• 关键词: Animal Model; Animals; Asbestos; Attitude; Biological; Biological Markers; Biometry; Chemoprevention; Collaborations; Communities; Core Facility; Data; Detection; Development; Disease; Earth science; Ecology; Environment; Environmental Health; Epigenetic Process; Evaluation; Fostering; Fox Chase Cancer Center; Genetic; Glues; Goals; Government Agencies; Hazardous Substances; Health; Health Sciences; Home environment; Human; Incidence; Integrative Medicine; Lead; Leadership; Legal patent; Lung diseases; Mediating; Mentors; Mesothelioma; Methodology; Methods; Modeling; Molecular; Monitor; Movement; Pennsylvania; Philadelphia; Postdoctoral Fellow; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Research Training; Resolution; Resources; Risk; Science; Serum; Services; Signal Recognition Particle; Site; Sociology; Students; Superfund; Techniques; Technology; Technology Transfer; Toxic effect; Training; Training Programs; Translating; Translational Research; Translations; Universities; base; biomarker discovery; certificate program; cohesion; community living; design; environmental justice; environmental toxicology; epidemiology study; exposed human population; fungus; human subject; innovation; instrumentation; liquid chromatography mass spectrometry; metabolomics; novel; particle; programs; public health relevance; remediation; response; social; superfund site; validation studies; wasting

DESCRIPTION (provided by applicant) The University of Pennsylvania Superfund Research and Training Program Center (Penn SRP Center) evolved as a direct consequence of concerns from the community living proximal to the BioRit Asbestos Superfund site in Ambler, PA. The community at Ambler has actively participated in the design of projects to be tackled by the Center. As a result, the Center will consist of two Environmental Science Projects and four Biomedical Science Research Projects, which will be underpinned by one Research Core and four Service Cores. These Projects and Cores will explore various aspects of asbestos fate, exposure, remediation, and adverse health effects. Environmental Science Projects 1 and 2 are entitled "Remediation of Asbestos Particles" and "Mobility and Fate of Asbestos Particles," respectively. Biomedical Science Projects 3-6 are entitled "Social Determinants of Risk And Attitudes about Asbestos in a Superfund Environmental Justice Community," "Animal Models of Mesothelioma," "Chemoprevention of Asbestos-Induced Lung Diseases," and "Biomarkers of Asbestos Exposure" The Cores comprise an Administrative Core (Core A), the Community Engagement Core (Core B), the Research Translation Core (Core C), the Biostatistical Research Support Core (Core D), and the Interdisciplinary Training Core (Core E). The goals of the Penn SRP Center will be accomplished through the leadership of two senior highly accomplished investigators, Dr. Ian A. Blair (Director) and Dr. Trevor M. Penning (Deputy Director). The Penn SRP is underpinned by four highly significant entities. First, the Penn Center of Excellence in Environmental Toxicology (CEET) provides an academic home, with enormous resources to draw upon. Second, the CEET Translational Biomarker Core provides instrumentation and resources for conducting sophisticated biomarker discovery and validation studies. Third, the CEET Integrative Health Sciences Facility Core will provide support for human subject study design and storage of annotated biospecimens. Fourth, the existing CEET Certificate Program and T32 Training Program in Environmental Health Sciences provide a resource of potential students and postdoctoral fellows who could be recruited into the Penn SRP Center. Advanced techniques for the detection, assessment, and evaluation of the effect on human health of hazardous substances will involve the development of a new animal model of asbestos-induced mesothelioma. Methods to assess the risks to human health presented by hazardous substances will involve novel metabolomics methodology using high resolution liquid chromatography-mass spectrometry will be developed to identify human populations that are exposed to asbestos. Methods and technologies to detect hazardous substances in the environment will involve two quite separate approaches. One will involve the use of earth science-based methodology to monitor the movement of asbestos within dump sites and the other will involve a sociological study to identify how asbestos exposure can occur and whether this can explain the cluster of asbestos-induced mesotheliomas in Ambler. A basic biological method to be employed for reducing the amount and toxicity of a hazardous substance will involve the remediation of asbestos by mycorrhizal fungi-mediated conversion it to a non-toxic molecular form. Therefore, although these projects evolved in response to the Ambler community's concerns (EPA Region 3), the results can be readily translated to the fifteen other asbestos sites that are present in five of the other EPA Regions (2, 5, and 8-10).

描述（由申请人提供） 宾夕法尼亚大学超级基金研究与培训计划中心（Penn SRP中心）的直接结果是宾夕法尼亚州Ambler的Biorit石棉Superfund网站的直接结果。 Ambler的社区积极参与了该中心应对的项目设计。结果，该中心将由两个环境科学项目和四个生物医学科学研究项目组成，这些项目将以一个研究核心和四个服务核心为基础。这些项目和核心将探索石棉命运，暴露，补救和不利健康影响的各个方面。环境科学项目1和2分别为“石棉颗粒的修复”和“石棉颗粒的移动性和命运”。生物医学科学项目3-6的标题为“在超级基金环境正义社区中对石棉的社会决定因素和态度，“间皮瘤的动物模型”，“石棉诱导的肺部疾病的化学预防” （核心C），生物统计研究支持核心（核心D）和跨学科培训核心（核心E）。 Penn SRP中心的目标将通过两位高级成就的调查人员Ian A. Blair博士（主任）和Trevor M. Penning博士（副主任）的领导来实现。 Penn SRP的基础是四个高度重要的实体。首先，宾夕法尼亚州环境毒理学卓越中心（CEET）提供了一个学术家，并提供了巨大的资源。其次，CEET翻译生物标志物核心提供了进行复杂的生物标志物发现和验证研究的仪器和资源。第三，CEET综合健康科学设施核心将为人类学科研究设计和注释的生物测量的存储提供支持。第四，现有的CEET证书计划和环境卫生科学的T32培训计划提供了潜在的学生和博士后研究员的资源，这些研究员可以被招募到Penn SRP中心。用于检测，评估和评估对危险物质人类健康影响的先进技术将涉及开发石棉诱导的间皮瘤的新动物模型。评估危险物质带来的人类健康风险的方法将涉及使用高分辨率液相色谱质量光谱法新的代谢组学方法，以识别暴露于石棉的人群。检测环境中有害物质的方法和技术将涉及两种非常独立的方法。一种将涉及使用基于地球的基于地球的方法来监测垃圾场在垃圾场中的运动，而另一个将涉及一项社会学研究，以确定如何发生石棉暴露，以及这是否可以解释石棉诱导的中间体群集在Ambler中。一种用于减少危险物质的数量和毒性的基本生物学方法将涉及通过菌根真菌介导的转化为无毒分子形式对石棉进行修复。因此，尽管这些项目是根据Ambler社区的关注而演变的（EPA第3区），但结果可以很容易地转化为其他五个EPA地区（2、5和8-10）中存在的15个石棉站点。