Neurodevelopmental effects of Perfluorinated Chemicals

全氟化学品对神经发育的影响

基本信息

批准号：
9243107
负责人：
Zeyan Liew
金额：
$ 15.83万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9243107
关键词：
11 year old 5 year old Age Animals Anxiety Attention Attention deficit hyperactivity disorder Autistic Disorder Behavior Birth Blood specimen Brain Brain Diseases Cerebral Palsy Chemical Exposure Chemicals Child Clinical Clinical Psychology Cognition Collaborations Complex Congenital Abnormality Convulsions Country Data Data Collection Denmark Development Diagnosis Disease Eating Disorders Ecology Education Endocrine disruption Environment Epidemiologic Methods Epidemiology Epigenetic Process Epilepsy Exposure to Febrile Convulsions Fetal Development Fetus First Pregnancy Trimester Future Genes Genetic Gonadal Steroid Hormones Growth and Development function Hearing Hospitals Human Human Genetics Intelligence Knowledge Life Link Measures Mediation Medical Psychology Memory Mental Depression Mental Health Mental disorders Mentors Mothers Motor Motor Skills Neonatal Neurodevelopmental Disorder Neuropsychological Tests Neuropsychology Obsessive-Compulsive Disorder Online Systems Outcome Pathway Analysis Performance Phenotype Plasma Positioning Attribute Pregnancy Pregnant Women Problem behavior Process Property Psychotic Disorders Questionnaires Registries Regulation Reporting Research Resources Sampling Schools Scientific Advances and Accomplishments Secondary Schools Self Perception Social Problems Stress Surveys Symptoms Testing Thyroid Hormones Thyrotropin Thyroxine Time Training Universities Vision adverse outcome case control cognitive function cohort early childhood executive function fetal follow-up gene environment interaction in utero insight instrument interest man neurobehavioral neurodevelopment neuropsychiatric disorder neurotoxic novel offspring persistent organic pollutants population based prenatal prenatal exposure professor repository screening sex skills social skills statistics toxicant training opportunity

项目摘要

ABSTRACT This proposal builds on the candidate’s dissertation research that examined the associations between prenatal exposure to perfluorinated chemicals (PFCs) and three specific neurodevelopmental outcomes, including autism, attention-deficit/hyperactivity disorder, and cerebral palsy in the Danish National Birth Cohort (DNBC) that consists of ~100,000 mothers and children. PFCs are widespread persistent organic pollutants, and pregnant women and fetuses are often involuntarily and nearly ubiquitously exposed to these synthetic compounds since the 1950s. Animal studies suggest that PFCs are developmental toxicants but evidence from human studies is sparse. Decade long collaborations between UCLA and Aarhus University enabled the candidate to gain access to the unique, large-scale, nationwide Danish cohorts and registries for research. The proposed study will greatly expand the use of DNBC and various Danish registers and allow for the very first time examination of the link between prenatal PFC exposures and an array of neurodevelopmental outcomes never investigated before, including (1) extensive neuropsychological assessments of intelligence, cognition, attention, memory and motor skills in children at age 5; (2) hospital diagnosis of epilepsy; (3) the child’s social competence and mental health at age 11; and (4) intellectual capacity and school performance up to age 16. The proposed studies will capitalize upon the valuable resource of stored maternal pregnancy blood samples from DNBC, allowing a reliable and valid assessment of PFC exposure levels during fetal development. The proposal will be pursued within the context of a strong ongoing collaboration between the UCLA Department of Epidemiology and Aarhus University, adding new partners from the UCLA Medical Psychology Assessment Center (MPAC) and Department of Human Genetics. This application builds on Dr. Liew’s expertise in environmental sciences and advanced epidemiologic methods. It will allow him to newly gain the necessary training in clinical psychology, environmental statistics, and neurobehavioral epi/genetics and to build a skillset compatible with conducting future cutting-edge epi-gene/environment interactions research that optimally uses existing large bio-sample repositories in the Nordic countries. Drs. Beate Ritz and JØrn Olsen have agreed to mentor the candidate through the K99 process. Dr. Robert Asarnow will provide training in administrating/scoring complex neuropsychological instruments and clinical knowledge of neuropsychiatric disorders. Dr. Michael Jerrett will provide training opportunities in environmental statistics and exposure assessment referred to as the ‘external exposome’. Dr. Steve Horvath will provide training in advanced gene-environment and epigenetic network analysis. The contents of this application provide a strategy to position the candidate to successfully launch into a tenured professor track position and equip him with the necessary skills to move towards independence and pursue R01 proposals.

抽象的该提议建立在候选人的论文研究基础上，该研究检查了产前的关联暴露于全氟化学物质（PFC）和三个特定的神经发育结果，包括丹麦民族出生队列（DNBC）的自闭症，注意力缺陷/多动障碍和脑瘫这包括约100,000个母亲和儿童。 PFC是广泛的持续性有机污染物，并且孕妇和胎儿通常在非自由而普遍地暴露于这些综合自1950年代以来的化合物。动物研究表明，PFC正在发展毒性，但人类研究很少。加州大学洛杉矶分校和奥尔胡斯大学之间的长期合作使候选人可以访问独特的大规模，国家范围内的丹麦同伙和研究登记处。拟议的研究将大大扩展DNBC和各种丹麦登记册的使用，并允许第一对产前PFC暴露与一系列神经发育结果之间的联系的时间检查以前从未研究过，包括（1）对智力，认知，认知，认知的广泛神经心理学评估 5岁儿童的注意力，记忆和运动技能；（2）医院诊断癫痫；（3）孩子的社交 11岁时的能力和心理健康；（4）最高16岁的智力能力和学校表现。拟议的研究将利用存储的材料妊娠血液样本的宝贵资源来自DNBC，可以在胎儿发育过程中对PFC暴露水平进行可靠且有效的评估。该提案将在加州大学洛杉矶分校之间强烈持续合作的背景下提出流行病学系和奥尔胡斯大学，添加了UCLA医学心理学的新伴侣评估中心（MPAC）和人类遗传学系。此应用程序建立在Liew博士的基础上环境科学和高级流行病学方法的专业知识。这将使他刚获得在临床心理学，环境统计和神经行为的遗传学和遗传学方面进行的必要培训与进行未来尖端的Epi-Gene/环境互动研究相兼容的技能最佳利用北欧国家现有的大型生物样本存储库。博士。 Beate Ritz和JørnOlsen 已经同意通过K99程序指导候选人。罗伯特·阿萨诺（Robert Asarnow）博士将提供培训行政/评分复杂的神经心理学仪器和神经精神病学的临床知识疾病。迈克尔·杰雷特（Michael Jerret）博士将提供环境统计和曝光的培训机会评估称为“外部杂物”。史蒂夫·霍瓦斯（Steve Horvath）博士将提供高级培训基因环境和表观遗传网络分析。此应用程序的内容为将候选人定位为成功启动到终身教授轨道职位，并为他配备迈向独立并购买R01提案的必要技能。