Sex hormones and arthritis in a long lived animal model

长寿动物模型中的性激素和关节炎

• 批准号: 9488925
• 负责人: STEVEN N. AUSTAD
• 金额: $ 6.21万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9488925
• 关键词: Age; Aging; Aging-Related Process; Alabama; Animal Model; Animals; Area; Arthritis; Assimilations; Bioenergetics; Biological Models; Biology; Biology of Aging; Birds; Body Composition; Brown Fat; Budgets; Cells; Chronic Disease; Collaborations; Communities; Comparative Biology; Comparative Study; Complement; Complex; Country; Custom; Data Analytics; Data Set; Dependence; Dependency; Development; Disease; Distant; Elderly; Energy Intake; Energy Metabolism; Environment; Expenditure; Fishes; Fostering; Genes; Geroscience; Goals; Gonadal Steroid Hormones; Health; Heart; Instruction; Intake; Invertebrates; Investigation; Laboratories; Life; Link; Longevity; Mammals; Metabolic; Metabolism; Methodology; Methods; Mitochondria; Mitochondrial DNA; Modeling; Modernization; Mus; Nuclear; Nutrient; Obesity; Organelles; Oxidative Stress; Pattern; Phylogenetic Analysis; Population; Regulation; Research; Research Infrastructure; Research Personnel; Resistance; Resources; Rodent; Sampling; Services; Shock; Signal Transduction; Sum; Techniques; Technology; Temperature; Thinness; Tissues; Training Support; Training and Education; Twin Multiple Birth; United States National Institutes of Health; Universities; Variant; Yeasts; cohort; comparative; detection of nutrient; energy balance; experimental study; fly; indexing; innovation; instrumentation; interest; longitudinal analysis; metabolic abnormality assessment; metabolomics; mitochondrial dysfunction; novel; programs; public health relevance; reduced food intake; research and development; symposium

DESCRIPTION (provided by applicant): The University of Alabama at Birmingham (UAB) proposes to establish a Nathan Shock Center of Excellence in the Basic Biology of Aging focused on comparative energetics and aging. Energetics is comprehensively defined for this purpose as the study of the causes, mechanisms, and consequences of the acquisition, storage, and utilization of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species, in this case as it relates to health and aging. Nearly a century of aging research has reinforced the link between energetics and aging. In modern terms this link is reified as dysregulated mitochondrial function, metabolic signaling, and nutrient responsiveness. The twin objectives of the Center will be to (1) explore in greater depth and detail than previously the complex relationship among cellular and organismal energetics and their relationship to health and aging, and (2) provide quantitative, state-of-the-art technologies and novel methodologies in the assessment and analysis of energetics to the basic aging research community at large. In pursuit of these objectives, we propose developing three research cores. First, the Comparative Organismal Energetics Core will provide expertise and cutting edge instruction and methodology for determining complete whole animal energy balance (intake, assimilation, expenditure) and body composition, including regional distribution of white and brown adipose tissue, in living animals of various species including flies, fish, mice or other mammals, under any ambient temperature or activity regime. Second, the Comparative Mitochondrial Health Assessment Core will provide integrated, quantitative energetics analysis at the level of the organelle, cell, or tissue for both traditional and emerging animal models, including targeted metabolomics, assessment of mitophagy, and oxidative stress. Mitochondrial-nuclear exchange models are also available to enable experiments that evaluate the contribution of mtDNA variation to bioenergetics. Third, the Comparative Data Analytics Core will provide innovative analytic approaches to data sets linking comparative energetics to organismal health and longevity. With these research cores plus the administrative and research development core, we aim to: (i) facilitate hypothesis-driven research and leverage these technologies into new projects, interactions, and collaborations nationwide in basic aging research; (ii) foster meaningful novel interactions among investigators within UAB and across the region and country; and (iii) provide resources, education, training, and direction to junior investigators through the intellectual resources and research infrastructure, the Center will develop. In sum, these cores and the outstanding cohort of investigators assembled for this Center will provide unique expertise and novel collaborative opportunities for new and established investigators at UAB and beyond.

描述（由申请人提供）：阿拉巴马大学伯明翰分校 (UAB) 提议建立一个衰老基础生物学 Nathan Shock 卓越中心，重点关注比较能量学和衰老。为此目的，能量学被全面定义为对代谢能量的获取、储存和利用的原因、机制和后果的研究。比较能量学是对多个尺度和多个物种的代谢过程的研究，在这种情况下，它与健康和衰老有关。近一个世纪的衰老研究加强了能量学与衰老之间的联系。用现代术语来说，这种联系被具体化为线粒体功能、代谢信号和营养反应失调。该中心的双重目标是 (1) 探索 比以前更深入和详细地了解细胞和有机体能量学之间的复杂关系及其与健康和衰老的关系，以及（2）为基础知识的能量学评估和分析提供定量的、最先进的技术和新颖的方法。整个老龄化研究界。为了实现这些目标，我们建议开发三个研究核心。首先，比较有机体能量学核心将提供专业知识和前沿指导和方法，用于确定不同物种活体动物的完整整体能量平衡（摄入、同化、消耗）和身体成分，包括白色和棕色脂肪组织的区域分布包括苍蝇、鱼、老鼠 或其他哺乳动物，在任何环境温度或活动状态下。其次，比较线粒体健康评估核心将为传统和新兴动物模型提供细胞器、细胞或组织水平的综合定量能量学分析，包括靶向代谢组学、线粒体自噬和氧化应激评估。线粒体-核交换模型也可用于评估 mtDNA 变异对生物能学贡献的实验。第三，比较数据分析核心将为将比较能量学与有机体健康和长寿联系起来的数据集提供创新的分析方法。 凭借这些研究核心加上行政和研究开发核心，我们的目标是：（i）促进假设驱动的研究，并将这些技术应用于全国范围内基础老龄化研究的新项目、互动和合作； (ii) 促进 UAB 内部以及整个地区和国家的研究人员之间有意义的新颖互动； (iii) 通过中心将开发的智力资源和研究基础设施，为初级研究人员提供资源、教育、培训和指导。 总之，这些核心人员和为该中心聚集的优秀研究人员队伍将为阿拉巴马大学及其他地区的新老研究人员提供独特的专业知识和新颖的合作机会。