Core B: Repository Core

核心 B：存储库核心

• 批准号: 9249125
• 负责人: JACK C REIDLING
• 金额: $ 5.43万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9249125
• 关键词: Animal Model; Archives; Biological Models; Catalogs; Cell model; Cells; Data; Databases; Deposition; Effectiveness; Equipment and supply inventories; Goals; Huntington Disease; Intention; Methods; Molecular Models; Network-based; Neurodegenerative Disorders; Online Systems; Pathology; Peptides; Preparation; Production; Program Research Project Grants; Protocols documentation; Reagent; Research Personnel; Research Support; Resource Development; Resource Sharing; Resources; Site; Standardization; Structure; Time; Tissues; United States National Institutes of Health; Work; chaperonin; innovation; molecular modeling; novel therapeutics; programs; repository; success; vector

CORE B: REPOSITORY CORE PROJECT SUMMARY/ABSTRACT In order to facilitate the goal of utilizing innovative molecular, cellular and animal model systems to examine the interactions between mHTT and the TRiC network and to examine TRiC reagent modulations impact on HD pathology, we will establish a repository core. Repositories are a critical resource for multi-researcher initiated studies and have been established for NIH programs examining neurodegenerative diseases and disorders. In general, repositories store and catalogue various reagents, protocols and other critical data with the overall intention aimed at rapidly facilitating sharing resources for the development of new therapies. Establishing a repository core for the work in the described proposal is a vital part of the Program Project Grant to support the project goals. The Repository Core will support research throughout the projects by facilitating production of standardized high quality peptide, vector, cell and tissue reagents, archiving of reagents and protocols and distribution to project sites. Specific aims are to; 1) Establish a physical core for deposition of TRiC and HTT reagents and a Program specific network, 2) Coordinate utilization of the Core

核心B：存储库核心 项目摘要/摘要 为了促进利用创新的分子，细胞和动物模型系统的目标 MHTT与TRIC网络之间的相互作用并检查TRIC试剂调制对 高清病理，我们将建立一个存储库核心。存储库是多研究者的关键资源 开始研究，并已针对检查神经退行性疾病和 疾病。通常，存储库存储和分类各种试剂，协议和其他关键数据 总体意图旨在快速促进共享新疗法的资源。 在描述的提案中为工作建立存储库核心是计划项目赠款的重要组成部分 支持项目目标。存储库核心将通过促进整个项目的研究 产生标准化的高质量肽，载体，细胞和组织试剂，试剂的存档和 协议和项目站点的分配。具体目标是； 1）建立一个物理核心来沉积 TRIC和HTT试剂以及特定程序网络，2）核心核心利用率