Michigan Center on Lifestage Environmental Exposures and Disease

密歇根生命阶段环境暴露和疾病中心

• 批准号: 9058296
• 负责人: Rita K Loch-Caruso
• 金额: $ 150.25万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9058296
• 关键词: Address; Adolescent; Adult; Affect; Age; Aging; Bioinformatics; Child; Chronic Disease; Clinical; Communities; Community Outreach; Complex; Core Facility; Coupled; Development; Disease; Disease Pathway; Endocrine; Environmental Exposure; Environmental Health; Epidemiology; Fostering; Foundations; Funding; Future; Genomics; Goals; Grant; Health; Health Sciences; Human Biology; Infant; Inflammation; Knowledge; Life; Longevity; Medical; Metabolic; Michigan; Mission; National Institute of Environmental Health Sciences; Oxidative Stress; Pilot Projects; Predisposition; Prevention Research; Public Health; Research; Research Activity; Research Personnel; Research Support; Research Training; Resources; Scientist; Staging; Strategic Planning; Structure; Superfund; Training; Translating; Translations; Universities; career; career development; disorder prevention; epigenomics; human disease; improved; innovation; middle age; novel; prenatal; prevent; programs; public health intervention; public health relevance; reproductive

 DESCRIPTION (provided by applicant) This is the first competing renewal application for the Environmental Health Sciences (EHS) Core Center at the University of Michigan, submitted in the final year of the initial four years of NIEHS support. The Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center of Lifestage Environmental Exposures and Disease (M- LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the preconception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods of life. The Center builds on a strong foundation of research activity and support at the University of Michigan in this emergent arena of environmental public health, with 16 NIEHS grants moving into the next funding period that includes a Children's Environmental Health and Disease Prevention Research Center and participation in a Superfund Research Program Center. The mission of M-LEEaD is to accelerate research that defines impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve medical and public health interventions for the mitigation of chronic disease. The Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of mechanisms by which environmental exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to create synergy for stimulation of innovative research. The Facility Cores are: 1) Integrated Health Sciences Core (IHSC); 2) Exposure Assessment Core (EAC); and 3) Omics and Bioinformatics Core (OBIC). Research Teams are organized around key mechanistic pathways of disease: 1) Inflammation & Oxidative Stress; 2) Genomics & Epigenomics; and, 3) Endocrine & Metabolic Disruption. Research is coupled with the engagement of stakeholder communities through the Community Outreach and Engagement Core (COEC) and training of future leaders in EHS through the Center Career Development Program. The functioning of the Center is overseen by an Administrative Core. M-LEEaD strives to accomplish its mission through the following specific aims: 1) Integrate and build upon existing institutional programs and facilities to provide structure and resources that accelerate understanding of the complex relationships among environmental exposures, human biology, and disease; 2) Foster integration, coordination, and cooperation among investigators across traditional disciplinary boundaries to conduct high-quality research that translates to improved strategies towards preventing environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages, but especially those at early- and mid-career stages, to engage in research that addresses critical, emerging questions in environmental health; and, 4) Interact with affected communities in a bidirectional manner to identify community environmental health concerns and to translate research findings into community engagement opportunities.

 描述（由申请人提供） 这是密歇根大学的第一个相互竞争的环境健康科学（EHS）核心中心申请 Niehs支持。该中心围绕着对环境暴露的关键窗户作为重要的疾病决定者的易感性的主题，形成了密歇根州生活环境暴露与疾病（M-Leead）。在本应用中使用的LifEstage是指与临床认可的发展，中年和衰老阶段，与孕前，产前，婴儿，儿童，青少年，成人年龄以及成人衰老时期有关。该中心建立在密歇根大学在这个新兴环境公共卫生领域的强大研究活动和支持的基础上，其中16个NIEHS赠款进入了下一个资金，其中包括儿童环境健康和疾病预防研究中心，并参与了超级资助研究计划中心。 M leead的使命是加速研究，以定义脆弱生活阶段环境暴露的影响，并促进这些发现的翻译，以改善医学和公共卫生干预措施以减轻慢性病。该中心通过采用新颖的跨学科方法的既定和新研究人员的基础设施支持来实现其使命，从而增加了对环境暴露目标脆弱阶段的机制的理解。通过包括试点项目计划，三个设施核心以及三个研究团队的综合中心计划提供了对研究的支持，以创造协同刺激创新研究的协同作用。设施核心是：1）综合健康科学核心（IHSC）； 2）暴露评估核心（EAC）； 3）OMICS和生物信息学核心（OBIC）。研究小组围绕关键的疾病机械途径进行组织：1）炎症和氧化应激； 2）基因组学和表观基因组学； 3）内分泌和代谢中断。研究与利益相关者社区通过社区宣传和参与核心（COEC）的参与以及通过中心职业发展计划对EHS未来领导者的培训。中心的功能由管理核心监督。 M-Leead努力通过以下特定目的来完成其使命：1）整合并建立在现有的机构计划和设施的基础上，以提供对环境暴露，人类生物学和疾病之间复杂关系的结构和资源； 2）在传统学科边界之间的研究人员之间建立融合，协调和合作，以进行高质量的研究，转化为预防环境引起的疾病的改进策略； 3）通过在关键职业阶段为科学家提供支持，尤其是在职业阶段和中期阶段的科学家来建立程序化和科学能力，以研究解决环境健康中关键，新兴问题的研究； 4）以双向方式与受影响的社区进行互动，以确定社区环境健康问题，并将研究结果转化为社区参与机会。