Lifestage Exposures and Adult Disease

生命阶段暴露和成人疾病

基本信息

批准号：
8258265
负责人：
Rita K Loch-Caruso
金额：
$ 104.5万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-15 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8258265
关键词：
Address Adult Advisory Committees Age Area Asthma Awareness Basic Science Bioinformatics Biological Center Core Grants Chronic Disease Clinical Research Cohort Studies Collaborations Communities Community Health Education Community Outreach Consult Consultations Core Facility Critiques Data Developing Countries Development Discipline Disease Education and Outreach Educational workshop Endocrine Disruptors Environmental Epidemiology Environmental Exposure Environmental Hazards Environmental Health Epigenetic Process Etiology Exposure to Faculty Funding Gene Expression Generations Genetic Predisposition to Disease Genomics Goals Health Health Sciences Human Biology Human Resources Individual Informatics Institution Interactive Kiosk Interdisciplinary Study Laboratories Leadership Life Link Measures Metabolic syndrome Metal exposure Methodology Metric Michigan Mission Modification National Institute of Environmental Health Sciences Nature Neurodegenerative Disorders Nutrient Online Systems Oxidative Stress Patients Pilot Projects Population Preventive Intervention Price Procedures Process Productivity Proteomics Recruitment Activity Regulation Research Research Design Research Personnel Research Proposals Resources Role Scientist Screening procedure Services Staging Strategic Planning Structure Technology Therapeutic Intervention Tissue Banking Tissue Banks Toxic Environmental Substances Training Translating Translational Research Universities Work base biobank career career development design early life exposure epigenomics experience flexibility gene environment interaction global environment human disease improved innovation insight member metabolomics next generation novel novel strategies operation particle pre-clinical premature prevent programs response statistics success symposium tool

项目摘要

The University of Michigan-NIEHS Center is a new entity that will bring together basic and translational scientists into a partnership focused on the theme of "Lifestage Exposures and Adult Disease". The mission is to promote translational research using novel multi-disciplinary approaches to understand the impact of environmental exposures on adult chronic disease through mechanisms involving epigenetic modifications during vulnerable stages of life. This is the culmination of a 2-year planning process of building collaborations (including a major partnership with the CTSA) and functioning as a de-facto preliminary Center. The robust base of research includes projects addressing a variety of environmental toxicants, a large portfolio of cohort studies (and associated biorepositories) spanning the age spectrum, disease-specific research Centers (and associated tissue banks), and basic research on epigenetic mechanisms. In this revised application, the investigators retain their recognized strengths while increasing their focus, decreasing their targeted areas from 6 to 3, each now associated with a Research Team with senior leadership, and decreasing their membership by almost 40%. The investigators' Research Teams will focus on "Epigenetic Regulation", "Oxidative Stress" and "Endocrine Disruptors", subthemes that build off of the Center's strengths. The work starts with an initial emphasis on four diseases well-represented in the investigators' current research portfolio (asthma, prematurity, metabolic syndrome, and neurodegenerative disease), with the flexibility to expand as the Center grows and matures. The Center will sponsor seminars; a Pilot Project Program that capitalizes on major institutional leveraging; outstanding young Center scientists; and outreach and education to the broader scientific and lay community. The research will be facilitated by an Administrative Core and five service cores related to Exposures, Biological Responses, Integrative Health Sciences, Environmental Statistics and Bioinformatics. The Integrated Health Sciences Core will manage a web-based portal providing an innovative interactive kiosk for obtaining critical information on the resources, Core facilities, and tools for research. Core faculty will also provide "translational services", for consulting on the design of translational research and use of their biorepositories and Core facilities. A revised Community Outreach and Education Core will work with the investigators and a Stakeholder Advisory Board to engage in an enhanced range of activities. Administration of the Center will be facilitated by an active Executive Committee and outstanding scientists serving on the External Advisory Committee.

密歇根大学Niehs大学中心是一个新实体，它将将基本和转化的科学家汇总到一个以“生命性暴露和成人疾病”为主题的伙伴关系中。该任务是使用新型的多学科方法来促进翻译研究，以通过在脆弱的生活阶段涉及表观遗传修饰的机制来了解环境暴露对成人慢性疾病的影响。这是一项为期两年的建设合作计划（包括与CTSA建立的主要合作伙伴关系）的高潮，并充当事实上的初步中心。研究的强大基础包括针对各种环境有毒物质的项目，大量的队列研究组合（及相关的生物症状），涵盖了年龄谱，特异性研究中心（及相关的组织库）以及对表观遗传机制的基础研究。在此修订后的应用程序中，调查人员保留了公认的优势，同时将其专注力增加，将目标区域从6降低到3，每个地区现在与具有高级领导的研究团队相关联，并将其成员减少了近40％。研究人员的研究团队将专注于“表观遗传调节”，“氧化压力”和“内分泌扰动器”，这些子主题是基于中心的优势。这项工作首先强调了四种疾病在研究人员当前的研究组合（哮喘，早产，代谢综合征和神经退行性疾病）中的良好代表性，并且随着中心成长的增长而扩大的灵活性。该中心将赞助研讨会；一项试点项目，利用主要的机构杠杆作用；杰出的年轻中心科学家；以及对更广泛的科学和外行社区的宣传和教育。这项研究将由行政核心和五个服务核心促进，与暴露，生物学反应，综合健康科学，环境统计和生物信息学有关。综合健康科学核心将管理基于网络的门户网站，该门户提供创新的交互式信息亭，以获取有关研究资源，核心设施和研究工具的关键信息。核心教师还将提供“转化服务”，以咨询其设计和使用其生物局限器和核心设施的设计。经过修订的社区外展和教育核心将与调查人员和利益相关者顾问委员会合作，从事加强活动。该中心的管理将由一个积极的执行委员会和外部咨询委员会任职的杰出科学家促进。