Multiuser Image-guided small animal X-ray Platform.

多用户图像引导小动物 X 射线平台。

• 批准号: 9274114
• 负责人: MOHAN NATARAJAN
• 金额: $ 57.62万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274114
• 关键词: Advisory Committees; Air Pressure; Anesthetics; Animals; Biological; Cells; Core Facility; Department of Defense; Equipment; FDA approved; Failure; Funding; Future; Head; Immobilization; Income; Journals; Laboratories; Life; Manufacturer Name; Mus; Nature; Performance; Physicians; Positioning Attribute; Productivity; Publications; Radiation exposure; Radioactive; Research Personnel; Research Project Grants; Roentgen Rays; Running; Safety; Sampling; Schools; Science; Scientist; Seminal; Source; System; Technical Expertise; Therapeutic Studies; Time; Transgenic Organisms; United States Department of Veterans Affairs; United States National Institutes of Health; anticancer research; biological research; cancer therapy; design; image guided; irradiation; medical schools; operation; research study; targeted delivery

We are requesting funds to purchase a SARRP image-guided x-ray platform in order to continually support a total of 26 research projects. Among the currently funded projects that requires the use of the irradiator, nine of them are NIH RO1, one PO1 and one U-42 projects. Additionally, one funded FDA approved phase1/2 study and four NIH RO1 projects that are likely to get funded (currently under council review) proposed to use the irradiator. Apart from that, four other federally funded projects (US Department of Defense, Veteran Administration) and six state- or institutional-funded project depend on the irradiator use. The track record and productivity out of the current irradiator use is significant with seminal publications including the journals Nature, Mol. Cell Biol., J Biol. Chem., PNAS, and Cancer Research. As an added benefit, the irradiation facility is integrated with other institutional core facilities including institutional transgenic core platform. Currently the investigators perform their radiation exposures for biological samples in a Gamma Cell-40 irradiator which has been in use since 1980. As of March 2010, the manufacturer proclaimed this 35-year old 137Cs source irradiator an end-of-useful lifecycle and informed that the company can no longer guarantee replacement parts on this old unit. It periodically shows a faulty door-lock system and air pressure resulting in inappropriate positioning of the exposures heads or over exposure due to failure in unlocking the door. When safety system kicks-in, due to unsecured door locks, sometimes, system fails to switch on. In addition, since this decades-old equipment has no provision for partial body irradiation or targeted delivery, it is unable to meet the requirements of several current and newly approaching research studies. Unlike the old irradiator SARRP 200 can be used for animals other than mice. Built-in immobilization system allows the users to expose the animals under anesthetic condition which is not possible with the current irradiator. The SARRP image guided irradiator platform has no radioactive source and is designed specifically as Cs replacement for biological research. Additionally, SARRP has several advantageous over its principal commercial competitors. The SARRP 200 irradiation system is chosen for its performance more suited for the current and future users, wide use in several laboratories, safety, durability, self-shielding, and its useful life time. We have a carefully constituted an internal advisory committee for a productive operation of the irradiator for an extended period of time. With a strong institutional support and technical expertise by running the irradiator for the past several years we are confident that we can diligently operate the irradiator and support the current projects and meet the challenges/ requirements of incoming studies in future. Both physicians from the Medical School and the NCI designated Cancer Therapy Research Center (CTRC), and translational/basic scientists with multiple NIH projects from UTHSCSA Graduate School of Biomedical Sciences can take full advantage of this equipment.

我们要求资金购买SARRP图像引导的X射线平台，以便不断支持 共有26个研究项目。在当前资助的项目中，需要使用辐照机，九个 它们是NIH RO1，一个PO1和一个U-42项目。此外，一项资助的FDA批准了阶段1/2研究和 四个可能会得到资助（目前正在理事会审查）的NIH RO1项目提议使用 辐照器。除此之外，其他四个联邦政府资助的项目（美国国防部，退伍军人 行政管理）和六个国家或机构资助的项目取决于辐照机的使用。往绩记录和 在当前的辐射器中，生产力在包括期刊在内的开创性出版物中很重要 自然，摩尔。细胞生物，J Biol。化学，PNA和癌症研究。作为额外的好处，辐照设施 与其他机构核心设施（包括机构转基因核心平台）集成在一起。目前 研究人员在具有的伽马细胞-40辐射因子中对生物样品进行辐射暴露 自1980年以来一直在使用。截至2010年3月，制造商宣布了这个35岁的137CS来源irradiator 用途结束的生命周期，并告知该公司无法再保证在此旧的零件上替换零件 单元。它定期显示出故障的门锁系统和气压，导致不适当的位置 由于解锁门的故障而导致的头部或过度暴露。当安全系统启动时，由于 无抵押的门锁，有时系统无法打开。此外，由于这个数十年的设备具有 没有针对部分身体照射或有针对性的交付的规定，它无法满足几个要求的要求 当前和新近的研究研究。与旧的辐照器Sarrp 200不同，可用于动物 除了小鼠。内置固定系统允许用户在麻醉下暴露动物 当前的辐照器是不可能的。 SARRP图像指导的辐照器平台没有 放射性来源，专门设计为CS替代生物学研究。另外，萨尔普 比其主要商业竞争对手有几个优势。 SARRP 200辐照系统是 选择其性能更适合当前和未来的用户，在几个实验室，安全， 耐用性，自我屏蔽及其有用的寿命。我们有一个仔细组成的内部咨询委员会 为了在很长一段时间内进行辐照器的生产性操作。有强有力的机构支持 和技术专业知识，通过运行辐照机，在过去的几年中，我们有信心我们可以努力 操作辐照器并支持当前项目，并满足进来的挑战/要求 将来的研究。来自医学院的医生和NCI指定的癌症治疗研究 Center（CTRC），以及来自UTHSCSA研究生院的多个NIH项目的转化/基础科学家 生物医学科学可以充分利用该设备。