Emphysema and Inflammatory Biomarkers and Risk of Osteoporosis in Men with COPD

肺气肿和炎症生物标志物以及男性慢性阻塞性肺病患者骨质疏松症的风险

• 批准号: 9337253
• 负责人: JESSICA BON
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9337253
• 关键词: Acute; Address; Alveolar Macrophages; Animal Model; Antibodies; Autoantibodies; Autoantigens; Autoimmune Process; Autoimmunity; Binding; Biological Markers; Bone Density; Bone Resorption; Cachexia; Cells; Chronic Obstructive Airway Disease; Consensus; Data; Diagnostic radiologic examination; Endoplasmic Reticulum; Female; Fibrinogen; Fracture; Frequencies; Future; Goals; Guidelines; Health; Hip Fractures; Human; IL6 gene; Immunologics; Incidence; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interleukin-6; Knowledge; Link; Literature; Longitudinal cohort; Low Prevalence; Measures; Mediating; Molecular Chaperones; Morbidity - disease rate; Obstructive Lung Diseases; Osteoclasts; Osteoporosis; Osteoporosis prevention; Pathogenesis; Pathogenicity; Pathologic; Patients; Play; Population; Prevalence; Prevention strategy; Process; Production; Proteins; Public Health; Pulmonary Emphysema; Pulmonary Function Test/Forced Expiratory Volume 1; Risk; Risk Factors; Roentgen Rays; Role; Smoker; Spinal Fractures; Steroids; Symptoms; Testing; Time; Translations; Veterans; Woman; X-Ray Computed Tomography; bone; bone loss; bone turnover; circulating biomarkers; endoplasmic reticulum stress; epidemiology study; glucose-regulated proteins; insight; male; men; mortality; novel; osteoporosis with pathological fracture; osteoporotic bone; physical inactivity; precursor cell; predictive marker; promoter; prospective test; public health relevance; pulmonary function; response; screening; skeletal; targeted treatment; time interval; treatment strategy

 DESCRIPTION (provided by applicant): Low bone mineral density (BMD) is associated with chronic obstructive lung disease (COPD) independent of traditional osteoporosis risk factors, including physical inactivity, steroid use, ad cachexia. However, osteoporosis in men with COPD is often underdiagnosed due to lack of consensus on osteoporosis screening guidelines in this group of patients. Systemic inflammation plays a key role in the pathogenesis of both COPD and osteoporosis; but few studies have shown a relationship between specific systemic inflammatory biomarkers and either low BMD or accelerated loss of BMD over time. Immunologic alterations likewise contribute to the pathogenesis of both COPD and osteoporosis but the role of autoimmunity in COPD-related osteoporosis has not been studied. An independent association between low BMD and emphysema has been supported by the literature, but the mechanism for this association is unknown. This project's overall goal is to identify specific systemic inflammatory and autoimmune processes associated with both concurrent and progressive BMD loss and emphysema in men with COPD. This goal will be accomplished by establishing a two-year longitudinal c o h o r t o f m e n w i t h C O P D and attaining baseline and two-year assessments of BMD, radiographic emphysema, a n d pulmonary function. Inflammatory biomarker levels will be measured at six month intervals and during episodes of acute exacerbation of COPD (AECOPD). Systemic inflammatory and autoimmune biomarkers associated with BMD loss, measured by dual x-ray absorptiometry, emphysema progression, measured by quantitative CT scan, and incident hip or vertebral fractures over the two-year time interval will be identified. Changes in systemic inflammatory and autoimmune biomarker levels with AECOPD and the relationship to bone turnover and cumulative BMD loss will also be assessed. The findings from this project will identify criteria for male COPD patients at risk of accelerated BMD loss in whom early and serial BMD assessments may be beneficial, provide insight into pathogenic mechanisms linking COPD and osteoporosis, and provide novel targets for osteoporosis prevention and treatment strategies in men with COPD. This project will also address an unmet public health need given that most data on skeletal health are in women.

 描述（由申请人提供）： 低骨矿物质密度（BMD）与慢性阻塞性肺部疾病（COPD）有关，与传统的骨质骨质因素无关，类固醇的使用，AD恶病质，但是，COPD男性的骨质疏松症经常因缺乏共识而造成的骨质疏松症。骨质疏松症的筛查指南是一组患者，但很少有研究表现出特定的系统性炎症性生物标志物与BMD低的人之间的关系。与COPD相关的骨质疏松症中的自身免疫性尚未是独立的关联BMD对BMD的两年评估，放射线肺气肿，N D肺功能。时间间隔将是识别的。可能有益，提供与COPD和骨质疏松症联系起来的致病机制，并为COPD男性的骨质疏松症印度饮食策略提供了新的目标。