Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health

将空气质量混合物、气候和人类健康联系起来的新方法

• 批准号: 9123594
• 负责人: John Lanier Pearce
• 金额: $ 23.52万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9123594
• 关键词: Address; Air; Air Pollutants; Air Pollution; Area; Award; Biological; Biostatistical Methods; Birth; Cardiovascular Diseases; Climate; Cohort Studies; Complex; Development; Doctor of Philosophy; Elderly; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemiologic Methods; Epidemiologic Studies; Epidemiology; Foundations; Funding; Generations; Health; Heating; Human; Infant; Institutes; Investigation; Knowledge; Lead; Link; Lung diseases; Mentors; Meteorology; Methodology; National Institute of Environmental Health Sciences; Outcome; Phase; Positioning Attribute; Public Health; Research; Resources; Risk; Role; Scientist; Series; Staging; Statistical Methods; Technology; Temperature; Testing; Time; Training; United States Environmental Protection Agency; Universities; Variant; Work; ambient air pollution; atmospheric processes; base; career; climate change; climate variability; design; epidemiology study; improved; mortality; novel strategies; pollutant; response; skills; spatiotemporal

PROJECT SUMMARY: Urban air pollution is a significant public health problem with estimated mortality impacts predominantly among infants and elderly people with pre-existing cardiovascular and respiratory disease. Research on ambient air pollution health effects has begun shifting research objectives away from the single-pollutant paradigm to a more multipollutant or mixtures perspective in order to better understand the impacts of “real world” air pollution exposures on human health. Another area that is fundamentally linked to air quality and of increasing concern for public health is climate change. During the initial K99 phase, I will work closely with mentors to develop improved statistical methodologies for assessing the effects of multipollutant exposures in epidemiological studies, a natural extension of my current postdoctoral research. I will shift focus from identifying the types of air pollutant mixtures that occur in the environment to characterizing multipollutant exposures for epidemiological research. These will be applied to two ongoing epidemiological investigations that are being conducted within the Southeastern Center for Air Pollution Epidemiology (SCAPE); a US EPA funded Clean Air Research Center (CLARC, R834799) shared between Emory University and Georgia Institute of Technology: a short-term ecological study and a long-term cohort study. During the mentored phase, I will develop multipollutant temporal profiles for the investigation of short-term associations with multipollutant exposure and cardiorespiratory health outcomes. Next, I will develop multipollutant spatial profiles for the investigation of long-term associations between multipollutant exposure and the development of respiratory disease. During this phase, I will also receive new training in biostatistical and epidemiologic methods focused on environmental epidemiology at Emory University. Transitioning to independence in the R00 phase of the award, I will merge these new skills with my PhD training as I pursue research focused on understanding the implications of climate on air quality mixtures. My first independent aim will examine the meteorological sensitivity of specific multipollutant combinations in order to better understand potential changes in air pollutant mixtures under various climate scenarios. The final proposed aim is to develop environmental profiles for the examination of human health vulnerability to heat and multipollutant mixtures. At the conclusion of this award, I will have demonstrated expertise in analyzing effects for the emerging research areas of multipollutant mixtures and climate variability, providing a firm basis for my career as an environmental health scientist focusing on exposure characterizations for epidemiological research.

项目摘要：城市空气污染是一个重大的公共卫生问题，估计死亡率 在婴儿和老年患者心血管和呼吸道 疾病。关于环境空气污染健康影响的研究已开始将研究目标转移到 单污染物范式到更多的多币或混合物的观点，以便更好地了解 “现实世界”空气污染对人类健康的影响。从根本上与空气相关的另一个领域 质量和对公共卫生的越来越关注的是气候变化。在最初的K99阶段，我将工作 与导师密切相关，以开发改进的统计方法来评估多币的影响 流行病学研究中的暴露是我目前的博士后研究的自然扩展。我将转移重点 从识别环境中发生的空气污染物混合物的类型到表征多币 流行病学研究的暴露。这些将应用于两个正在进行的流行病学研究 在东南空气污染流行病学中心（SPAPE）进行的；美国EPA 资助的清洁空气研究中心（CLARC，R834799）共享埃默里大学与佐治亚研究所之间 技术：一项短期生态研究和一项长期队列研究。在修补阶段，我将 开发多层临时概况，用于投资与多币的短期关联 暴露和心肺健康结果。接下来，我将为 研究多层暴露与呼吸道发展之间的长期关联 疾病。在此阶段，我还将接受以生物统计和流行病学方法为重点的新培训 埃默里大学环境流行病学。在R00阶段过渡到独立性 奖励，我将在我购买专注于理解研究的研究时将这些新技能与博士培训合并 气候对空气质量混合物的影响。我的第一个独立目标将检查气象 特定多币组合的敏感性，以更好地了解空气污染物的潜在变化 在各种气候场景下的混合物。最终提议的目的是为 检查人类健康脆弱性和多层混合物的脆弱性。在此奖项结束时，我 将在分析的多层研究领域的分析效果方面证明专业知识 混合和气候变异性，为我作为环境健康科学家的职业提供了牢固的基础 专注于流行病学研究的暴露特征。

项目成果

Associations between multipollutant day types and select cardiorespiratory outcomes in Columbia, South Carolina, 2002 to 2013.

2002 年至 2013 年南卡罗来纳州哥伦比亚市多污染物日类型与特定心肺结果之间的关联。

• DOI: 10.1097/ee9.0000000000000030
• 发表时间: 2018
• 期刊: Environmental epidemiology (Philadelphia, Pa.)
• 作者: Pearce,JohnL;Neelon,Brian;Bozigar,Matthew;Hunt,KellyJ;Commodore,Adwoa;Vena,John
• 通讯作者: Vena,John

Exploring the influence of short-term temperature patterns on temperature-related mortality: a case-study of Melbourne, Australia.

• DOI: 10.1186/s12940-016-0193-1
• 发表时间: 2016-11-10
• 期刊: Environmental health : a global access science source
• 作者: Pearce JL;Hyer M;Hyndman RJ;Loughnan M;Dennekamp M;Nicholls N
• 通讯作者: Nicholls N