Mechanisms and Impact of StAR Activation in ALD

StAR 激活对 ALD 的机制和影响

基本信息

批准号：
9201292
负责人：
JOSE C FERNANDEZ-CHECA
金额：
$ 16.43万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9201292
关键词：
Acute Address Affect Alcohol abuse Alcohol consumption Alcoholic Liver Diseases Alcohols Animal Model Bile Acid Biosynthesis Pathway CASP1 gene California Cause of Death Cell Separation Cells Cholesterol Cirrhosis Communities Complex Cyclic AMP-Dependent Protein Kinases Data Developed Countries Development Disease Disease model Education and Outreach Environment Faculty Fostering Funding Future Generations Generations Genetic Genetic Transcription Grant Health Personnel Hepatic Hepatocyte Home environment Inflammasome Inflammation Inflammatory Inner mitochondrial membrane Institution International Kupffer Cells Life Style Lipids Lipoid congenital adrenal hyperplasia Liver Mediating Medical Mission Mitochondria Modeling Molecular Mus National Institute on Alcohol Abuse and Alcoholism Organelles Outcome Pancreatic Diseases Pathogenesis Pathologic Pharmacology Phosphorylation Phosphotransferases Physiological Play Positioning Attribute Postdoctoral Fellow Predisposition Preparation Prevention Preventive Program Research Project Grants Property Protein Family Proteins Public Health Publications Regulation Research Research Infrastructure Research Personnel Research Training Resources Respiratory Chain Rodent Role Sampling Scientist Signal Pathway Steroid biosynthesis Steroids Stress Tertiary Protein Structure Testing Therapeutic Training Training and Education Transcriptional Activation Transcriptional Regulation United States National Institutes of Health alcohol consequences alcohol research base cholesterol trafficking clinically relevant collaborative environment cytokine feeding genetic approach innovation insight loss of function member mitochondrial dysfunction mitochondrial membrane novel outreach overexpression physical property simulation symposium undergraduate student

项目摘要

Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 57 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center's interactive environment and infrastructure have facilitated in the past 5 years, a 152% increase in research base to $8.5M/year; 4 new U01/P01 programs; 198 publications; generation of 14 NIH-funded early-stage investigators; transition of 8 postdocs to faculty positions; training 166 graduate and 20 undergraduate students; and organizing 3 community seminars and 4 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 229 rodents as ALPD models and 241 model samples for 17 outside investigators; 329 liver cell isolation preparations for 14 investigators; and support for grant acquisition and application by 12 outside investigators since the last renewal. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center's theme: elucidation of the priming and sensitizing mechanisms for ALPD; 2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers; 3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis; and 4) outreach efforts to disseminate the center's new findings to lay public, health care workers and scientists in our home and global communities.

酒精性肝脏和胰腺疾病（ALPD）和肝硬化构成了全球领先的生活方式疾病。南加州ALPD和Cirrhosis研究中心统一了来自南加州主要学术机构的57名调查人员，以追求成为疾病研究，培训和外展领导者的共同使命。自1999年成立以来，该中心一直致力于开发和使用临床相关的动物模型，以获取对倾向倾向的高级ALPD的分子机制的新见解。这些努力最终达到了最近的开创性发现，这些发现极大地提高了我们对酒精引起的协同ALPD的理解和第二次打击。在过去的5年中，该中心的互动环境和基础设施促进了研究基础152％，至850万美元； 4个新的U01/P01程序； 198出版物； 14个由NIH资助的早期研究人员产生；过渡了8个博士后到教师职位；培训166名毕业生和20名本科生；并组织3个社区研讨会和4场国际研讨会。作为一个独特的国家资源，该中心已为全国各地的科学社区提供了：229种啮齿动物作为ALPD型号，并为17名外部研究人员提供了241个模型样本； 14名研究人员的329个肝细胞分离制剂；自上次续签以来，12名外部调查人员的赠款获得和申请支持。该中心将通过促进：1）有利于对该中心主题的领先研究的环境来继续作为ALPD和Cirrhosis的独特科学科学中心：阐明ALPD的启动和敏感机制； 2）提供独特的模型，创新的遗传方法和专业知识，包括其他NIAAA酒精研究中心的研究者； 3）全面的教育和培训，以培养ALPD和肝硬化的后代科学家； 4）宣传努力，以传播该中心的新发现，以在我们的家庭和全球社区中为公众，卫生保健工作者和科学家奠定。