Cancer Center Support Grant

癌症中心支持补助金

基本信息

批准号：
9188838
负责人：
Thomas Patrick Loughran
金额：
$ 12.5万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-16 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9188838
关键词：
Affect Appalachian Region Area Arts Basic Cancer Research Basic Science Biomedical Engineering Biometry Cancer Center Cancer Center Support Grant Cancer Control Cancer Patient Caring Categories Chemicals Clinical Clinical Cancer Center Clinical Investigator Clinical Research Clinical Trials Computational Biology Diagnosis Discipline of Nursing Disease Drops Education Elements Engineering Epigenetic Process Equilibrium Evolution Faculty Faculty Recruitment Floor Flow Cytometry Fostering Foundations Funding Future Gene Targeting Goals Grant Gynecologic Oncology Head and Neck Surgery Hematology Image Analysis Immunology Immunotherapy Instruction Investigation Knowledge Laboratories Leadership Malignant Neoplasms Microscopy Minority Groups Mission Molecular Molecular Genetics Outpatients Patient Care Patient Education Patients Peer Review Phase Physicians Positioning Attribute Prevention Program Development Radiation Oncology Recruitment Activity Request for Applications Research Research Infrastructure Research Personnel Resource Sharing Sampling Science Scientist Signal Transduction Source Speed Stem cell transplant Structure Surgical Oncology System Technology Tissues Transgenic Organisms Translational Research Translations Underserved Population Universities University of Virginia Cancer Center University resources Virginia Woman anticancer research base biobank biomedical informatics cancer care cancer cell clinical application clinical investigation cohort college design education research epigenomics faculty support human tissue infrastructure development medical schools member multidisciplinary neuro-oncology oncology oncology program pre-clinical programs research facility software systems structural biology targeted cancer therapy tumor

项目摘要

DESCRIPTION (provided by applicant): This application seeks renewed CCSG funding for the University of Virginia (UVA) Cancer Center, a matrix cancer center that brings together 132 Members from 23 Departments in the Schools of Medicine, Nursing, and Engineering, and in the College of Arts and Sciences. The UVA Cancer Center receives $19.85M from NCI, $48.62M from other peer-reviewed sources, and $8.72M from non-peer-reviewed sources, for a total of $77.19M in overall funding. Through faculty recruitment, re-organization, and robust infrastructure development, the UVA Cancer Center has continued to build on its exceptional basic-science foundations and has greatly enhanced its ability to accelerate clinical and translational cancer-focused research. Twenty-six new faculties have been recruited, including thirteen clinical investigators and/or physician-scientists and eight bioengineers, computational biologists, and/or molecular geneticists. To enhance trans-disciplinary and translational research and cancer focus, programs were consolidated so that all have basic science Members integrated with disease-focused and clinical or translational investigators. The Cancer Center has five Programs; Cancer Cell Signaling (SIG), Chemical and Structural Biology (CSB), Molecular Genetics and Epigenetics (GEN), Women's Oncology (WON), and Immunology/immunotherapy (IMM). The number of Full Members has been reduced by 30% and an Associate Member category has been created for investigators whose potential for peer-reviewed, cancer-focused research has yet to be actualized. This application requests support for eight Shared Resources: Advanced Microscopy, Biomolecular Analysis, Biorepository and Tissue Research, Flow Cytometry, Gene Targeting and Transgenic, Preclinical Tumor Analysis and Imaging, Biostatistics, and the Office for Clinical Research. A completely transformed infrastructure for translational and clinical research facilitates investigations using human tissues and the implementation of clinical trials. Major additions in research and clinical facilities strongly enhance the Cancer Center's ability to carry out its mission: New laboratory space covering 25,000 ft2houses IMM and WON Members, and a new cancer outpatient clinical building covering 151,000 ft2 will open in April 2011. Substantial activities have been initiated to reach underserved populations in minority groups and in Appalachia. This renewal application describes continued excellence in basic cancer research, enhanced cancer focus, and greatly strengthened clinical research leadership and infrastructure.

描述（由申请人提供）：本申请为弗吉尼亚大学（UVA）癌症中心寻求更新的CCSG资金，这是一个基质癌症中心，汇集了来自医学，护理和工程学学校以及艺术和科学学院的23个部门的132名成员。 UVA癌症中心从NCI获得了1985万美元，来自其他同行评审的来源的4862万美元，未经审查的来源获得了872万美元的收入，总资金总额为7719万美元。通过教师招聘，重组和强大的基础设施发展，UVA癌症中心继续以其卓越的基本科学基础为基础，并大大增强了其加速以临床和转化为中心的癌症研究的能力。已招募了26个新学院，包括13名临床研究者和/或医师科学家以及8位生物工程师，计算生物学家和/或分子遗传学家。为了增强跨学科和转化研究和癌症的关注，计划进行了整合，因此所有人都将基础科学成员与以疾病为中心的，临床或转化的研究者融为一体。癌症中心有五个计划；癌细胞信号传导（SIG），化学和结构生物学（CSB），分子遗传学和表观遗传学（Gen），女性肿瘤学（WON）以及免疫学/免疫疗法（IMM）。全部成员的数量已减少30％，并且为调查人员创建了一个副成员类别，这些调查人员的同行评审，以癌症为中心的研究尚未实现。该应用要求支持八个共享资源：高级显微镜，生物分子分析，生物验证和组织研究，流式细胞术，基因靶向和转基因，临床前肿瘤分析和成像，生物统计学，以及用于临床研究的办公室。用于转化和临床研究的完全转化的基础设施促进了使用人体组织和实施临床试验的研究。研究和临床设施中的主要补充强烈增强了癌症中心的能力执行任务：覆盖25,000 FT2Houses IMM并赢得的成员的新实验室空间，覆盖151,000 FT2的新的癌症门诊临床建筑将于2011年4月开放。已发起了实质性的活动，以吸引少数族裔和阿帕拉奇亚的少数人口。这种更新的应用描述了基础癌症研究，增强癌症的焦点以及极大地增强临床研究领导力和基础设施的持续卓越表现。