A longitudinal assessment of frailty in young adult survivors of childhood cancer

儿童癌症年轻幸存者虚弱的纵向评估

基本信息

批准号：
9056542
负责人：
Kirsten Kimberlie Ness
金额：
$ 53.52万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-07 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9056542
关键词：
Adolescent Age Aging Alkylating Agents Anthracyclines Behavior Bleomycin Brain Neoplasms Cancer Survivor Cell Line Cephalic Characteristics Chest Child Childhood Childhood Acute Lymphocytic Leukemia Childhood Cancer Treatment Chronic Chronic Disease Clinical Comorbidity Data Demographic Factors Development Diagnosis Diet Dietary Practices Disease Marker Dose Early treatment Elderly Evaluation Exercise Fatigue Female Funding Gender General Population Habits Health Health behavior Hodgkin Disease Hospitalization Housing Individual Institution Intervention Life Long-Term Survivors Malignant Childhood Neoplasm Malignant Neoplasms Measurement Measures Modality Normal tissue morphology Nutritional Onset of illness Organ Outcome Participant Persons Phenotype Physical Fitness Physical Function Physical activity Physiological Population Premature aging syndrome Prevalence Radiation Recruitment Activity Reporting Research Research Personnel Resources Risk Risk Factors Saint Jude Children&apos s Research Hospital Schedule Severities Shortness of Breath Smoking Smoking Status Survivors Symptoms Testing Time Toxic effect Travel Treatment Factor Treatment-Related Cancer United States Visit cancer cell childhood cancer survivor cohort design disability fitness frailty functional loss innovation interest member mortality peer pre-clinical premature prevent public health relevance screening sex therapy design young adult

项目摘要

DESCRIPTION (provided by applicant): Treatment for children with cancer has progressed over the past four decades so that, today, over 80% of children diagnosed with a malignancy will become long-term survivors. Currently, there are over 350,000 survivors of childhood cancer living in the United States; nearly 250,000 of these individuals are younger than age 40 years. Unfortunately, treatment for childhood cancer continues to require agents designed to destroy malignant cell lines, and normal tissue is not always spared. While early treatment-related organ specific toxicities are not always apparent, many childhood cancer survivors report symptoms that interfere with daily life, including exercise induced shortness of breath, fatigue, and reduce capacity to participate in physical activity. These symptoms may be a hallmark of premature aging, or frailty. Frailty is a phenotype most commonly described in older adults; it indicates persons who are highly vulnerable to adverse health outcomes. Frailty may help explain why nearly two thirds of childhood cancer survivors have at least one severe chronic health condition 30 years from diagnosis, why childhood cancer survivors are more likely than peers to be hospitalized for non-obstetrical reasons, and why they have mortality rates more than eight times higher than age-and-gender matched members of the general population. The aims of this proposal are to enumerate the prevalence of physiologic frailty over time in a group of young adult survivors of childhood cancer, to describe the association between frailty and the development or progression of chronic conditions, and to describe the associations between personal factors, cancer-related treatment modalities, health behaviors, and frailty in this population.

描述（由申请人提供）：过去 40 年来，儿童癌症治疗取得了长足进步，如今，超过 80% 的被诊断患有恶性肿瘤的儿童将成为长期幸存者。目前，美国有超过 350,000 名儿童癌症幸存者；其中近 250,000 人年龄在 40 岁以下。不幸的是，儿童癌症的治疗仍然需要旨在破坏恶性细胞系的药物，而正常组织并不总是能幸免。虽然早期治疗相关的器官特异性毒性并不总是明显，但许多儿童癌症幸存者报告了干扰日常生活的症状，包括运动引起的呼吸急促、疲劳和参与身体活动的能力降低。这些症状可能是过早衰老或虚弱的标志。虚弱是老年人最常见的一种表型。它表明那些极易受到不良健康后果影响的人。虚弱可能有助于解释为什么近三分之二的儿童癌症幸存者在诊断后 30 年内至少患有一种严重的慢性健康状况，为什么儿童癌症幸存者比同龄人更有可能因非产科原因住院，以及为什么他们的死亡率更高比年龄和性别匹配的普通人群高八倍以上。该提案的目的是枚举一组年轻的儿童癌症幸存者随时间的推移生理虚弱的患病率，描述虚弱与慢性病的发展或进展之间的关联，并描述个人因素之间的关联，该人群中与癌症相关的治疗方式、健康行为和虚弱状况。