An Ultra High Resolution SPECT System Integrated with a High-Field MRI Scanner

与高场 MRI 扫描仪集成的超高分辨率 SPECT 系统

• 批准号: 8496038
• 负责人: Chin-Tu Chen
• 金额: $ 33.71万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496038
• 关键词: Accounting; Address; Affect; Algorithms; Animals; Anodes; Area; Arts; Autoimmune Process; Bioluminescence; Caliber; Cathodes; CdZnTe; Cell Count; Cells; Chicago; Collimator; Contrast Media; Coupled; Custom; Detection; Development; Diabetes Mellitus; Dimensions; Electronics; Event; Fluorescence; Generations; Grant; Hemorrhage; Image; Imaging Techniques; Immunologic Monitoring; Incidence; Insulin-Dependent Diabetes Mellitus; Laboratories; Laboratory Research; Location; Magnetic Resonance Imaging; Magnetism; Medical; Metabolic; Methods; Mission; Modeling; Monitor; Mus; Non-Insulin-Dependent Diabetes Mellitus; Nuclear; Optics; Performance; Persons; Photons; Positioning Attribute; Positron-Emission Tomography; Quantitative Evaluations; Radioactivity; Radiolabeled; Research; Resolution; Signal Transduction; Stem cells; Structure of beta Cell of islet; System; T-Lymphocyte; Techniques; Thick; Time; Tissues; Transplantation; United States; Wages; Work; absorption; base; cell motility; cellular imaging; cost; design; detector; image reconstruction; imaging modality; in vivo; instrument; iron oxide; islet; light scattering; magnetic field; migration; novel; prototype; radiotracer; research study; response; single photon emission computed tomography; soft tissue; stem; tumor; ultra high resolution

DESCRIPTION (provided by applicant): In this project, we will develop a novel imaging system that combines a high-field MRI scanner and an ultrahigh resolution SPECT system for imaging metabolic and signaling targets in the pancreatic beta cell. This combined system comprises a 9.4 T 30 cm horizontal bore magnet (Oxford Instrument, Oxford, UK) with Bruker Avance Biospec (Bruker-Biospin, Billerica, MA) console equipped with 12 cm shielded gradient with maximum strength of 400mT/m, and a compact and ultrahigh resolution SPECT system that will be fitted inside the 12 cm diameter bore to allow simultaneous MR and SPECT imaging of mouse. The proposed SPECT system is based on an energy-resolved photon counting detector. It consists of pixelated CdZnTe (CZT) crystals (with 350 5m W 350 5m pitch), coupled to a custom- designed readout circuitry that utilizes an energy-resolved photon-counting (ERPC) ASIC (developed by Dr. Meng's group at UI) to readout anode pixels and the NCI-ASIC (developed by Brookhaven National Laboratory and Naval Research Laboratory) to readout the cathode signals. The ERPC detector offers (a) an ultrahigh intrinsic spatial resolution (<400 5m in all three dimensions) for 140keV 3-rays, (b) a wide dynamic range to cover 12-200keV, (c) a proven MRI- compatibility with minimized magnetic components, (d) the ability to extract signals simultaneously induced on adjacent anode pixels and the cathode, which provides critical information for correcting the event positioning error induced by the strong magnetic field, and (e) a compact form factor for packing multiple detectors into the MRI bore. The proposed imaging system combines a high-field (9.4 T) MRI scanner with an ultrahigh SPECT system. It allows an excellent co-registration of the features resolved in both MR and SPECT images. The proposed system will be applied for imaging metabolic and signaling targets in the pancreatic beta cell. The results of studies will enhance our understanding of the advantages and limitations of each imaging modality in specific models of 2cell loss and replication.

描述（由申请人提供）：在该项目中，我们将开发一种新型成像系统，该系统结合了高场 MRI 扫描仪和超高分辨率 SPECT 系统，用于对胰腺 β 细胞中的代谢和信号传导目标进行成像。该组合系统包括一个 9.4 T 30 cm 水平孔磁体（Oxford Instrument，英国牛津）和 Bruker Avance Biospec（Bruker-Biospin，Billerica，MA）控制台，配备 12 cm 屏蔽梯度，最大强度为 400mT/m，以及紧凑型超高分辨率 SPECT 系统将安装在直径 12 厘米的孔内，以允许对小鼠同时进行 MR 和 SPECT 成像。所提出的 SPECT 系统基于能量分辨光子计数探测器。它由像素化 CdZnTe (CZT) 晶体（350 5m W 350 5m 间距）组成，耦合到使用能量分辨光子计数 (ERPC) ASIC（由 UI 的孟博士团队开发）的定制设计读出电路。读取阳极像素，NCI-ASIC（由布鲁克海文国家实验室和海军研究实验室开发）读取阴极信号。 ERPC 探测器提供 (a) 140keV 3 射线的超高固有空间分辨率（所有三个维度均小于 400 5m），(b) 覆盖 12-200keV 的宽动态范围，(c) 经验证的 MRI 兼容性，最小化磁性组件，(d) 提取在相邻阳极像素和阴极上同时感应的信号的能力，这为校正强磁场感应的事件定位误差提供了关键信息，以及 (e) 紧凑的形式将多个探测器装入 MRI 孔的因素。所提出的成像系统将高场 (9.4 T) MRI 扫描仪与超高 SPECT 系统相结合。它可以对 MR 和 SPECT 图像中解析的特征进行出色的共同配准。所提出的系统将用于对胰腺β细胞中的代谢和信号传导目标进行成像。研究结果将增强我们对特定 2 细胞丢失和复制模型中每种成像方式的优点和局限性的理解。