University of Florida - Mt. Sinai Medical Center AD Research Center

佛罗里达大学西奈山医学中心 AD 研究中心

• 批准号: 8848980
• 负责人: Todd E Golde
• 金额: $ 152.19万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848980
• 关键词: Alzheimer' s Disease; Amyloid; Autopsy; Biological Markers; Brain; Brain imaging; Censuses; Clinical; Clinical Sciences; Clinical assessments; Cognitive; Communities; Consent; Country; Data; Data Set; Data Sources; Deltastab; Dementia; Diagnosis; Diagnostic; Disease; Early Diagnosis; Education; Education and Outreach; Educational Activities; Elderly; Enrollment; Ensure; Epidemic; Evaluation; Florida; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Health Professional; Hispanics; Image; Immunotherapeutic agent; Impaired cognition; Individual; Institutes; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medical center; Memory Disorders; Mission; Modeling; Neurodegenerative Disorders; Not Hispanic or Latino; Participant; Pathology; Patients; Phase; Pilot Projects; Play; Population; Population Heterogeneity; Positron-Emission Tomography; Professional Education; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Role; Science; Services; Site; Staging; Structure; Techniques; Testing; Training; Translational Research; United States; United States National Institutes of Health; Universities; Vision; Water; Work; base; clinical care; cohort; data management; design; effective therapy; fighting; functional decline; genetic analysis; improved; innovation; investigator training; mild cognitive impairment; neuropathology; novel; outreach; pre-clinical; prevent; programs; tool

DESCRIPTION (provided by applicant): Finding effective treatments and preventative therapies for Alzheimer's disease (AD) is one of the country's most serious unmet medical needs. With ~500,000 AD patients and >3 million at-risk individuals over age 65, Florida is an epicenter of the AD epidemic in the United States; yet, there are no active ADRCs or ADCCs primarily based in the State. In order to further our collective understanding of AD and related dementias, the University of Florida (UF)-Mount Sinai Medical Center (MSMC) AD Research Center (ADRC) will coalesce research efforts within the Wien Memory Disorder Center at MSMC in Miami and the UF in Gainesville. These efforts will capitalize on the clinical population in the Wien Center that is majority Hispanic, the expansive research capabilities at UF, and the infrastructure for translational research provided by the NIH funded UF Clinical and Translational Science Institute. Major goals of the UF-MSMC ADRC are to; i) further elucidate the correlation of early cognitive impairment to various biomarkers of brain structure and function; ii) understand predictors of decline in Hispanic and Non-Hispanic individuals; iii) support translational research efforts that will further the understanding of disease mechanisms; iv) lay the groundwork for improved designs for testing novel therapies for AD and related dementias, and; v) have a broad state-wide educational impact including recruitment of junior investigators into the AD field. In addition to the five required Cores, three Projects are proposed. Project I explores the hypothesis that MRI-based measures of free water can provide important theragnostic information in AD. Project II evaluates new cognitive paradigms that will be more sensitive to the earliest manifestations of AD in Hispanic and non-Hispanic populations. Project III will develop new models of mixed AD pathologies and evaluate immunotherapeutic approaches aimed at modifying these mixed pathologies. Having recognized the need for ADRCs in Florida, there is substantial multi-institutional support for this ADRC and, importantly, supplemental State of Florida legislative funding.

描述（由申请人提供）：为阿尔茨海默氏病（AD）寻找有效的治疗方法和预防疗法是该国最严重的未满足医疗需求之一。佛罗里达州有约500,000名AD患者和> 300万高风险的人，是美国广告流行病的中心。但是，没有主要基于该州的活动ADRC或ADCC。为了促进我们对AD和相关痴呆症的集体理解，佛罗里达大学（UF） - 山上西奈医学中心（MSMC）AD研究中心（ADRC）将在迈阿密MSMC和盖恩斯维尔的UF的WIEN记忆障碍中心内联合研究工作。这些努力将利用WIEN中心的临床人群，即大多数西班牙裔，UF的广泛研究能力以及由NIH资助的UF临床和转化科学研究所提供的转化研究基础设施。 UF-MSMC ADRC的主要目标是； i）进一步阐明了早期认知障碍与大脑结构和功能的各种生物标志物的相关性； ii）了解西班牙裔和非西班牙裔人群下降的预测因素； iii）支持转化研究工作，以进一步了解疾病机制； iv）为改进设计的设计奠定了基础，以测试用于AD和相关痴呆症的新型疗法，并且； v）在全州范围内具有广泛的教育影响，包括招募初级调查人员进入广告领域。除了五个必需的核心外，还提出了三个项目。项目I探讨了以下假设：基于MRI的游离水测量可以在AD中提供重要的the舌尖信息。项目II评估了新的认知范例，这些范式将对西班牙裔和非西班牙裔人群中AD最早的表现更敏感。 III项目将开发新的混合AD病理学模型，并评估旨在修饰这些混合病理的免疫治疗方法。认识到在佛罗里达州需要ADRC的必要性后，对这种ADRC以及佛罗里达州立法资金的补充状态都有大量的多机构支持。