The Development of Eating Behavior in Infancy

婴儿期饮食行为的发展

基本信息

批准号：
9111517
负责人：
Julie C Lumeng
金额：
$ 3.88万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9111517
关键词：
2 year old Adult Advertising Age Appetite Regulation Behavior Biology Birth Birth Weight Breast Feeding Child Childhood Consumption Cues Desire for food Development Diet Eating Behavior Energy Intake Food Future Goals Growth Hunger Individual Individual Differences Infant Intake Intervention Investigation Knowledge Lead Life Link Longevity Measurement Measures Methods Milk Modeling Mothers Motor Activity Newborn Infant Obesity Overweight Pattern Physical activity Prevention Prevention program Psychosocial Stress Public Health Reading Recruitment Activity Reporting Risk Factors Satiation Shapes Solid Sucrose Testing Time Translating Weight Weight Gain Work age group behavioral construct cohort early childhood eating in absence of hunger effective intervention feeding hedonic improved infancy infant temperament novel obesity prevention obesity risk prenatal prevent protective effect public health relevance response sedentary success sucking sweet taste perception

项目摘要

DESCRIPTION (provided by applicant): Obesity is a significant public health problem. Preventing obesity is much more effective than treating it and once obesity is established it is very likely to persist throughout the lifespan. Prevention programs have had limited success and efforts have therefore increasingly focused on younger and younger age groups. By age 2 years, 27 percent of children are already overweight or obese and the rate of weight gain in the first year of life is an independent and robust risk factor for obesity later in childhood and into adulthood, independent of prenatal factors or birth weight. Efforts have therefore begun to focus on the rate of weight gain in infancy. The mechanism of rapid weight gain in the first year of life is currently unknown. The classic predictors of obesity in later childhood and adulthood, such as physical activity, sedentary behavior, and dietary composition, do not translate directly to infancy. In addition, the accumulating body of evidence does not provide robust support for protective effects of breastfeeding or delayed introduction of solid foods. Interventionists have therefore most recently focused efforts on the notion that mothers misread infant hunger and satiety cues and as a result, over-feed them. Underlying these interventions is the implied hypothesis that infants would naturally accurately self-regulate caloric intake if mothers could accurately read the infant's cues. In this application we propose an alternate conceptual model, however. Specifically, we propose that some individuals have greater hunger than others, and that these inter-individual differences are detectable and have high stability from early infancy. We propose that in order to develop effective interventions to prevent rapid weight gain in infancy, there is a need to first understand infant hunger. The goal of this application is to bettr define distinct domains of infant eating behavior, their measurement, their development over time, their correlates, and their association with rapid infant weight gain. Ultimately, the work wll contribute to the basic scientific understanding of the ontogeny of appetitive drive very early in the life span and lead to the development of more precise and targeted interventions to shape infant appetitive drive. We will recruit a cohort of 325 infants in the newborn period and measure, using unique observational methods and maternal report measures, eating behavior constructs including sucking vigor, satiety responsiveness, hedonic response to sweet taste, soothing effect of sucrose, persistent working for food, and eating in the absence of hunger. Our specific aims therefore are: Aim 1: To identify domains of infant eating behavior and their trajectories of development over the first year of life. Aim 2: To test the hypothesis that specifi trajectories of specific infant eating behaviors are associated with more rapid rates of infant weight gain. Aim 3: To test the hypothesis that the infant eating behavior domains linked with rapid rates of weight gain are predicted by infant temperament; psychosocial stress; and maternal obesity, eating behavior, and diet.

描述（适用提供）：肥胖是一个重大的公共卫生问题。预防肥胖要比对其进行治疗更有效，一旦确定肥胖症，在整个生命周期中很可能会持续存在。预防计划取得了有限的成功，因此努力越来越集中在年轻年龄段。到2岁时，27％的儿童已经超重或肥胖，生命的第一年体重增加率是肥胖症的独立且强大的危险因素成年，独立于产前因素或出生体重。因此，努力已经开始专注于婴儿期的体重增加率。生命第一年快速体重增加的机制目前未知。童年和成年期肥胖的经典预测因素，例如体育锻炼，久坐行为和饮食成分，并不能直接转化为婴儿期。此外，积累的证据体系不能为母乳喂养或延迟引入固体食品提供强有力的支持。因此，干预主义者最近将努力集中在母亲小姐小说婴儿饥饿和饱腹感的观念上，因此，他们过度喂食。这些干预措施的基础是隐含的假设，即如果母亲能够准确地阅读婴儿的提示，婴儿自然会自然地自我调节的热量摄入量。但是，在此应用程序中，我们提出了一种替代概念模型。具体而言，我们建议有些人比其他人更大，并且这些个体间的差异是可以检测到的，并且从婴儿期开始就具有很高的稳定性。我们建议，为了制定有效的干预措施以防止婴儿期快速增加体重，需要首先了解婴儿的饥饿感。该应用的目的是确定婴儿饮食行为的不同领域，它们的测量，随着时间的流逝，相关性的发展以及与快速婴儿体重增加的关联。最终，这项工作将有助于在生命周期初期对开胃驱动的个体发育的基本科学理解，并导致开发更精确和有针对性的干预措施，以塑造婴儿的食欲驱动力。我们将使用独特的观察方法和孕产妇报告措施，包括吸吮活力，饱腹感反应能力，对甜味的味道，对蔗糖的舒缓作用，为食物的持久工作以及食物的持久作用以及饮食不足，使用了独特的观察方法和饮食行为构造，包括饮食活力，饱腹感反应，对食物的舒缓效果，包括吸吮活力，对食物的舒缓作用，招募行为构造，以及饮食。我们的具体目的是：目标1：确定婴儿饮食行为的领域及其在生命的第一年中的发展轨迹。目的2：检验以下假设：特定婴儿饮食行为的特定轨迹与婴儿体重增加率更快有关。目的3：测试以下假设：婴儿温度可以预测与快速体重增加率相关的婴儿饮食行为域；社会心理压力；以及物物肥胖，饮食行为和饮食。