Novel exposure metrics for assessing the effects of ultrafine and fine particulate matter on asthma in children

用于评估超细颗粒物和细颗粒物对儿童哮喘影响的新暴露指标

• 批准号: 9145680
• 负责人: Kirsten Anne Koehler
• 金额: $ 15.95万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9145680
• 关键词: Aerosols; Air Pollution; Algorithms; Animal Model; Asthma; Biological Markers; Caliber; Chemicals; Child; Childhood Asthma; Complement; Controlled Study; Data; Detection; Development; Epidemiologic Studies; Equipment; Exhalation; Exposure to; Geographic Locations; Goals; Health; Home environment; Hour; Inflammatory; Intervention; Leukotriene E4; Location; Measures; Metals; Monitor; Morbidity - disease rate; Morphology; Obesity; Outcome; Overweight; Oxidants; Oxidative Stress; Parents; Participant; Particle Size; Particulate Matter; Population; Positioning Attribute; Predisposition; Research Design; Resolution; Respiratory physiology; Role; Schools; Series; Source; Study models; Symptoms; System; Time; Ultrafine; Weight; Work; base; control trial; cooking; environmental intervention; evidence base; human study; inner city; novel; particle; particle exposure; pollutant; respiratory; respiratory health; temporal measurement; trafficking; ultrafine particle; urinary

Project Summary Particulate matter (PM) air pollution is known to exacerbate asthma symptoms in children; however, it is still unclear which metric (particle size, morphology or chemical composition) of PM is most relevant to respiratory health. The broad objective of this work is to determine which potentially modifiable factors of fine PM, including ultrafine particles (UFP), microenvironment, and peak exposure, are associated with respiratory effects in inner-city children with asthma. A second, related objective is to evaluate the effects of these fine PM factors on overweight children with asthma, a susceptible population recently identified by our Center. To accomplish these objectives, we will examine the effects of PNC and peak PM exposure in a panel study of 50 children with asthma, each of whom will be followed for 7 days with 4 days of continuous monitoring of PNC and PM2.5 mass, geographic location, biomarkers, and asthma outcomes. In Aim 1 we will evaluate the relationship between UFP and fine particles and asthma symptoms, lung function and inflammatory biomarkers. We will use the location information to apportion exposure into the microenvironments in which children spend time (e.g. home, school, transit) and evaluate the relationships between these microenvironmental exposures, as well as longer-term measures of exposure, on asthma outcomes. In Aim 2 we will develop an automated peak detection algorithm and evaluate the contribution of peak exposures to cumulative exposure and estimate the effects of peak exposures on children with asthma. Finally, in Aim 3, we will evaluate the role of weight as a susceptibility factor for the impact of UFP, microenvironmental, and peak exposures on asthma outcomes. We expect that this study design, taking advantage of recent technological advancements, will provide unprecedented ability to assess the importance of fine PM factors on asthma outcomes in children. Such evidence will allow for individualized environmental intervention strategies that target susceptible populations.

项目摘要 已知颗粒物（PM）空气污染会加剧儿童的哮喘症状；但是，仍然是 不清楚PM的哪种度量（粒度，形态或化学组成）与呼吸最相关 健康。这项工作的广泛目的是确定哪些可能修改的细胞pm因素， 包括超铁颗粒（UFP），微环境和峰值暴露与呼吸有关 哮喘内城儿童的影响。第二个相关的目标是评估这些精细PM的影响 超重儿童哮喘的因素，这是我们中心最近确定的易感人群的因素。到 实现这些目标，我们将在小组研究中检查PNC和PM PM暴露的影响50 患有哮喘的儿童，每个人都会随后持续7天，并连续监测PNC 和PM2.5质量，地理位置，生物标志物和哮喘结果。在AIM 1中，我们将评估 UFP与细颗粒以及哮喘症状，肺功能和炎症之间的关系 生物标志物。我们将使用位置信息将其分配到微环境中 孩子们花时间（例如家庭，学校，过境）并评估这些关系 微环境暴露以及长期暴露于哮喘结局。在目标2中 我们将开发一种自动峰检测算法，并评估峰值暴露对 累积暴露并估计峰值暴露对哮喘儿童的影响。最后，在AIM 3中，我们 将评估体重作为UFP，微环境和峰值影响的易感因子的作用 暴露于哮喘结果。我们希望这项研究设计，利用最近的技术 进步将提供空前评估良好PM因素对哮喘的重要性的能力 儿童的结果。此类证据将允许采取个性化的环境干预策略 目标易感人群。