Mentoring and Patient-Oriented Research in HIV Obstructive Lung Disease

HIV 阻塞性肺病的指导和以患者为导向的研究

• 批准号: 8848118
• 负责人: Alison Morris
• 金额: $ 11.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848118
• 关键词: Adult; Affect; Age; Antibiotics; Appointment; Attention; Award; Bacteria; Bacterial Translocation; Biota; Blood; Bronchoalveolar Lavage; CD4 Lymphocyte Count; Carbon Monoxide; Cardiovascular Diseases; Cell Wall; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Communities; Comorbidity; Complementarity Determining Regions; Complex; DNA; Data; Data Analyses; Detection; Development; Diffuse; Dimensions; Disease; Disease Progression; Education; Educational process of instructing; Ensure; Environment; Exposure to; Fellowship; Funding; Future; Gastrointestinal tract structure; Goals; HIV; HIV Infections; Health; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Human immunodeficiency virus test; Immune response; Immunity; Immunology; Impairment; Individual; Infection; Inflammation; Inflammatory Response; Institutes; Interleukin-8; Internal Medicine; Investigation; Laboratories; Lead; Link; Lung; Lung Inflammation; Lung diseases; Measures; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Mission; Modeling; Obstructive Lung Diseases; Organ; Outpatients; Pathogenesis; Pathway interactions; Peptide Hydrolases; Peripheral; Persons; Physiological; Physiology; Plasma; Play; Pneumocystis; Polymerase Chain Reaction; Population; Positioning Attribute; Primates; Probiotics; Pulmonary Inflammation; Qualifying; Research; Research Infrastructure; Research Personnel; Research Training; Residencies; Resources; Respiratory physiology; Ribosomal RNA; Role; Serum; Severity of illness; Site; Smoking; Smoking Status; Staging; Students; Symptoms; Systemic infection; T-Cell Activation; T-Lymphocyte; Technology; Testing; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; Work; airway obstruction; antiretroviral therapy; career; career development; clinically relevant; cohort; experience; fungus; innovation; microbial; microbial community; microbiome; microorganism antigen; mortality; neutrophil; novel; patient oriented research; polyglucosan; prevent; professor; programs; pulmonary function; pulmonary function decline; research study; respiratory; skills; therapeutic target; treatment trial

DESCRIPTION (provided by applicant): I am an Associate Professor of Medicine at the University of Pittsburgh and hold secondary appointments in Immunology and Clinical and Translational Research. I have established a research program in patient- oriented research (POR) in HIV-associated pulmonary disease with a focus on chronic obstructive pulmonary disease (COPD) and the role of the lung microbiome in COPD development and progression. I am committed to mentoring highly-qualified junior investigators in pulmonary, infectious diseases, and internal medicine in POR related to HIV lung disease and infections. I have been at the forefront of investigations of HIV associated lung diseases in the current era of antiretroviral therapy (ART) and am well-positioned to mentor junior investigators in this field. The institutional resources, the University of Pittsburgh Clinical and Translational Science Institute (CTSI) and its associated clinical research training programs, and the strong departmental and divisional support and commitment to the mission of training junior investigators will ensure the successful development of a mentoring program in POR in HIV-related pulmonary disease. My career goals in POR are: 1) to acquire new training relevant to my current projects including laboratory work and data analysis in microbiome studies, 2) to continue to support my research infrastructure and studies via NIH funding, 3) to continue my collaborations with other multicenter HIV studies for both my work and that of my trainees. My career goals in mentoring are: 1) to acquire formal mentoring training via coursework, 2) to expand training from experienced mentors, 3) to assist my current trainees in transitioning from K to R funding, 4) to teach in the Institute of Clinical Research Education (ICRE) Training Program, and 5) to take on new trainees at the fellowship, residency, and student levels. Over the course of the K24 award, I will continue to mentor my three current trainees and mentor five new research fellows and five new medicine residents or students. The overall hypothesis of this proposal is that the fungal mycobiome is linked to abnormal lung function and inflammation in HIV+ individuals. This hypothesis will be tested by the following aims: Aim 1) To test the hypothesis that the fungal lung mycobiome in HIV+ individuals with COPD differs from that in HIV+ subjects without COPD and is related to COPD progression; Aim 2) To test the hypothesis that fungal communities in the lung are associated with alterations in the lung environment; Aim 3) To test the hypothesis that fungal translocation is associated with COPD severity and progression in HIV. This project will provide an ideal training environment for mentoring junior investigators in a novel field of POR. We will utilize the clinical, translational, and scientific resources of the Pittsburgh HIV Lung Research Center. This award will allow sufficient time to increase my mentoring expertise, to enhance my research skills, and to help me guide trainees in POR studies by ensuring adequate effort for mentoring and for assisting trainees in career development and obtaining independent funding.

描述（由申请人提供）：我是匹兹堡大学医学副教授，并担任免疫学，临床和转化研究的次要任命。我已经建立了针对患者研究的研究计划（POR）在与HIV相关的肺部疾病中，重点是慢性阻塞性肺疾病（COPD）以及肺微生物组在COPD发育和进展中的作用。我致力于指导与HIV肺部疾病和感染有关的POR中高度合格的初级研究者。在当前抗逆转录病毒疗法（ART）时代，我一直处于对艾滋病毒相关肺部疾病的研究的最前沿，并且对这一领域的初级研究人员进行了良好的态度。机构资源，匹兹堡大学的临床与转化科学研究所（CTSI）及其相关的临床研究培训计划，以及对培训初级研究人员的强大部门和部门支持以及对HIV与HIV相关肺病POR的指导计划的成功发展的使命。我在POR中的职业目标是：1）获得与我当前项目有关的新培训，包括实验室工作和微生物组研究中的数据分析，2）继续通过NIH资助来支持我的研究基础设施和研究，3）继续与其他多中心艾滋病毒研究的合作，以进行我的工作以及受训者的工作。我在指导方面的职业目标是：1）通过课程获得正式的指导培训，2）从经验丰富的导师中扩大培训，3）帮助我当前的学员从K到R资金过渡，4）在临床研究教育研究所（ICRE）培训计划（ICRE）培训计划（5）中教书，以在伙伴，居住的居民，居住和学生水平上接受新学员。在K24奖的过程中，我将继续指导我目前的三名学员，并指导五名新研究人员和五名新的医学居民或学生。该提议的总体假设是真菌菌落与HIV+个体的异常肺功能和炎症有关。该假设将通过以下目的进行检验：目的1）检验以下假设：HIV+患者中的真菌肺菌落与没有COPD的HIV+受试者不同，并且与COPD进展有关；目标2）检验以下假设：肺中的真菌群落与肺部环境中的改变有关；目的3）检验了真菌易位与COPD严重程度和HIV进展有关的假设。该项目将为在POR的新领域中指导初级研究人员提供理想的培训环境。我们将利用匹兹堡艾滋病毒肺研究中心的临床，转化和科学资源。该奖项将使足够的时间增加我的指导专业知识，以提高我的研究技能，并通过确保足够的努力来指导和协助受训者进行职业发展和获得独立资金，从而帮助我指导受训者。