Mentoring and Patient-Oriented Research in HIV Obstructive Lung Disease

HIV 阻塞性肺病的指导和以患者为导向的研究

• 批准号: 8731029
• 负责人: Alison Morris
• 金额: $ 11.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8731029
• 关键词: Adult; Affect; Age; Antibiotics; Appointment; Attention; Award; Bacteria; Bacterial Translocation; Biota; Blood; Bronchoalveolar Lavage; CD4 Lymphocyte Count; Carbon Monoxide; Cardiovascular Diseases; Cell Wall; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Commit; Communicable Diseases; Communities; Comorbidity; Complementarity Determining Regions; Complex; DNA; Data; Data Analyses; Detection; Development; Diffuse; Dimensions; Disease; Disease Progression; Education; Educational process of instructing; Ensure; Environment; Exposure to; Fellowship; Funding; Future; Gastrointestinal tract structure; Goals; HIV; HIV Infections; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Human immunodeficiency virus test; Immune response; Immunity; Immunology; Impairment; Individual; Infection; Inflammation; Inflammatory Response; Institutes; Interleukin-8; Internal Medicine; Investigation; Laboratories; Lead; Link; Lung; Lung Inflammation; Lung diseases; Measures; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Mission; Modeling; Obstructive Lung Diseases; Organ; Outpatients; Pathogenesis; Pathway interactions; Peptide Hydrolases; Peripheral; Persons; Physiological; Physiology; Plasma; Play; Pneumocystis; Pneumonia; Polymerase Chain Reaction; Population; Positioning Attribute; Primates; Probiotics; Qualifying; Research; Research Infrastructure; Research Personnel; Research Training; Residencies; Resources; Respiratory physiology; Ribosomal RNA; Role; Serum; Severity of illness; Site; Smoking; Smoking Status; Staging; Students; Symptoms; Systemic infection; T-Cell Activation; T-Lymphocyte; Technology; Testing; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; Work; airway obstruction; antiretroviral therapy; career; career development; clinically relevant; cohort; experience; fungus; innovation; microbial; microbial community; microbiome; microorganism antigen; mortality; neutrophil; novel; patient oriented research; polyglucosan; prevent; professor; programs; public health relevance; pulmonary function; pulmonary function decline; research study; respiratory; skills; therapeutic target; treatment trial

PROJECT SUMMARY/ABSTRACT I am an Associate Professor of Medicine at the University of Pittsburgh and hold secondary appointments in Immunology and Clinical and Translational Research. I have established a research program in patient- oriented research (POR) in HIV-associated pulmonary disease with a focus on chronic obstructive pulmonary disease (COPD) and the role of the lung microbiome in COPD development and progression. I am committed to mentoring highly-qualified junior investigators in pulmonary, infectious diseases, and internal medicine in POR related to HIV lung disease and infections. I have been at the forefront of investigations of HIV- associated lung diseases in the current era of antiretroviral therapy (ART) and am well-positioned to mentor junior investigators in this field. The institutional resources, the University of Pittsburgh Clinical and Translational Science Institute (CTSI) and its associated clinical research training programs, and the strong departmental and divisional support and commitment to the mission of training junior investigators will ensure the successful development of a mentoring program in POR in HIV-related pulmonary disease. My career goals in POR are: 1) to acquire new training relevant to my current projects including laboratory work and data analysis in microbiome studies, 2) to continue to support my research infrastructure and studies via NIH funding, 3) to continue my collaborations with other multicenter HIV studies for both my work and that of my trainees. My career goals in mentoring are: 1) to acquire formal mentoring training via coursework, 2) to expand training from experienced mentors, 3) to assist my current trainees in transitioning from K to R funding, 4) to teach in the Institute of Clinical Research Education (ICRE) Training Program, and 5) to take on new trainees at the fellowship, residency, and student levels. Over the course of the K24 award, I will continue to mentor my three current trainees and mentor five new research fellows and five new medicine residents or students. The overall hypothesis of this proposal is that the fungal mycobiome is linked to abnormal lung function and inflammation in HIV+ individuals. This hypothesis will be tested by the following aims: Aim 1) To test the hypothesis that the fungal lung mycobiome in HIV+ individuals with COPD differs from that in HIV+ subjects without COPD and is related to COPD progression; Aim 2) To test the hypothesis that fungal communities in the lung are associated with alterations in the lung environment; Aim 3) To test the hypothesis that fungal translocation is associated with COPD severity and progression in HIV. This project will provide an ideal training environment for mentoring junior investigators in a novel field of POR. We will utilize the clinical, translational, and scientific resources of the Pittsburgh HIV Lung Research Center. This award will allow sufficient time to increase my mentoring expertise, to enhance my research skills, and to help me guide trainees in POR studies by ensuring adequate effort for mentoring and for assisting trainees in career development and obtaining independent funding.

项目摘要/摘要 我是匹兹堡大学医学副教授，并担任次要任命 免疫学，临床和转化研究。我已经建立了一项研究计划 艾滋病毒相关肺部疾病的定向研究（POR），重点是慢性阻塞性肺 疾病（COPD）以及肺微生物组在COPD发育和进展中的作用。我承诺 指导肺部，传染病和内科的高度合格的初级调查员 与HIV肺部疾病和感染有关的POR。我一直处于艾滋病毒调查的最前沿 当前抗逆转录病毒疗法（ART）时代的相关肺部疾病，对指导良好 该领域的初级调查员。机构资源， 匹兹堡大学的临床和 翻译科学研究所（CTSI）及其相关的临床研究培训计划及其强大 部门和部门的支持以及对培训初级调查人员的使命的承诺将确保 在HIV相关肺部疾病中，成功开发了POR的指导计划。 我的职业 POR的目标是：1）获得与我当前项目有关的新培训，包括实验室工作和数据 微生物组研究的分析，2）继续支持我的研究基础设施和NIH研究 资金，3）继续我与其他多中心艾滋病毒研究的合作 学员。我在指导方面的职业目标是：1）通过课程获得正式的指导培训，2） 从经验丰富的导师扩大培训，3），以帮助我目前的学员从K过渡到R资金， 4）在临床研究教育研究所（ICRE）培训计划中教书，5） 在团契，居住和学生级别的学员。在K24奖的过程中，我将继续 指导我目前的三名学员和指导五名新研究研究员和五名新医学居民或 学生。该提议的总体假设是真菌真菌组与异常肺有关 艾滋病毒+个体的功能和炎症。该假设将通过以下目的检验：目标1） 检验以下假设：艾滋病毒+患者中的真菌肺mycobiome与HIV+中的真菌肺Mycobiome不同 没有COPD的受试者，与COPD进展有关；目标2）测试真菌的假设 肺部的社区与肺部环境中的改变有关；目标3）检验假设 这种真菌的易位与艾滋病毒中的COPD严重程度和进展有关。该项目将提供一个 在新型POR领域指导初级研究人员的理想培训环境。我们将利用临床， 匹兹堡艾滋病毒肺研究中心的翻译和科学资源。该奖项将允许 足够的时间来增加我的指导专业知识，增强我的研究技能并帮助我指导 通过确保足够的指导和协助学员从事职业的努力，从事POR研究的学员 开发和获得独立资金。