FASEB SRC on Molecular Mechanism and Physiological Consequences of Protein Aggreg

FASEB SRC 关于蛋白质聚集体的分子机制和生理后果

基本信息

批准号：
8597867
负责人：
TRICIA R. SERIO
金额：
$ 4.18万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597867
关键词：
Address Affect Alzheimer&apos s Disease Amyloid Amyloid deposition Amyloidosis Amyotrophic Lateral Sclerosis Appearance Area Biochemical Biological Models Biological Phenomena Bovine Spongiform Encephalopathy Brain Cell physiology Cells Complex Cytoskeleton Development Diagnostic Disease Disease Progression Economic Burden Employee Strikes Etiology Event Familial Amyloid Neuropathies Fostering Goals Hormones Human Huntington Disease In Vitro Individual Link Modeling Molecular Montana Nature Nerve Degeneration Non-Insulin-Dependent Diabetes Mellitus Parkinson Disease Participant Pathology Pathway interactions Physicians Physiological Physiology Prion Diseases Process Property Proteins Publications Quality Control Research Research Personnel Scientist Series Structural Biologist Synapses System Therapeutic Thermodynamics Triage Ursidae Family Work amyloid formation amyloid structure amyloidogenesis cell type design effective therapy experience flexibility human disease in vivo innovation mathematical model nervous system disorder programs protein aggregate protein aggregation protein folding protein misfolding public health relevance symposium

项目摘要

DESCRIPTION (provided by applicant): While the association of amyloid with a variety of human diseases has been long appreciated, the precise molecular pathways governing amyloid appearance and amplification, the causality of these events in disease initiation and progression, and the sensitivity of these processes to therapeutic disruption remain significant open questions that are the subject of wide-ranging, cross-disciplinary research. This R13 proposal seeks core support for a FASEB Summer Research Conference on "Molecular Mechanisms and Physiological Consequences of Protein Aggregation." The ninth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to amyloidogenesis with the goal of ultimately intervening in these processes. The conference, to be held in Big Sky, Montana from June 23-28, 2013, will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on amyloidogenesis provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.

描述（由申请人提供）：虽然人们早已认识到淀粉样蛋白与多种人类疾病的关联，但控制淀粉样蛋白出现和扩增的精确分子途径、这些事件在疾病发生和进展中的因果关系以及这些过程的敏感性治疗中断仍然是重要的悬而未决的问题，也是广泛、跨学科研究的主题。该 R13 提案寻求对 FASEB 夏季研究会议“蛋白质聚集的分子机制和生理后果”的核心支持。这是自 1995 年开始的系列会议中的第九次会议，我们的计划旨在利用广泛的蛋白质、系统和方法来增进我们对与淀粉样蛋白生成相关的各种生物现象的理解，以最终干预这些过程。此次会议将于 2013 年 6 月 23 日至 28 日在蒙大拿州 Big Sky 举行，将为展示和讨论新出现的进展以及建立合作关系以应对该领域的重大挑战提供一个论坛。尺寸小（通常本次会议的 150 名与会者及其对淀粉样蛋白生成全方位研究的创新表述，为捕捉和整合这一过程的复杂性并协同推进该领域提供了独特的机会。