Investigation into protein quality control pathways in Dictyostelium discoideum

盘基网柄菌蛋白质质量控​​制途径的研究

• 批准号: 9141505
• 负责人: Kenneth Matthew Scaglione
• 金额: $ 38.5万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9141505
• 关键词: Animal Model; Biomedical Research; Cells; Dictyostelium; Dictyostelium discoideum; Disease; Homeostasis; Investigation; Lead; Pathway interactions; Property; Proteins; Quality Control; abstracting; novel; polyglutamine; prevent; protein aggregate; protein aggregation; protein misfolding; symptom treatment

Project Summary/Abstract Proteopathies are a class of at least 71 diseases characterized by the accumulation of protein aggregates. Protein aggregates are caused by an imbalance in protein homeostasis resulting in the accumulation of misfolded proteins. One major question in biomedical research is: How do cells recognize and deal with misfolded proteins? Serendipitously, we found that the model organism Dictyostelium discoideum normally expresses proteins with long polyglutamine tracts that cause one class of proteopathy. We have recently shown that Dictyostelium have an extraordinary ability to resist aggregation of a polyglutamine expanded protein know to aggregate in other model organisms. Here we propose to investigate mechanisms utilized by Dictyostelium to resist polyglutamine aggregation and explore novel aspects of the Dictyostelium protein quality control network.

项目摘要/摘要 蛋白质病是至少71种疾病，其特征是蛋白质聚集体的积累。 蛋白质聚集体是由蛋白质稳态失衡引起的，导致积累 错误折叠的蛋白质。生物医学研究中的一个主要问题是：细胞如何识别和处理 错误折叠的蛋白质？偶然地，我们发现模型有机体dictyostelium discoideum正常 用长的多谷氨酰胺道表达蛋白质，这些蛋白质引起一类蛋白质病。我们最近有 表明dictyostelium具有抗抗聚谷氨酰胺的聚集的非凡能力 蛋白质知道在其他模型生物中汇总。在这里，我们建议研究由 抗抑郁素聚集并探索dictyostelium蛋白的新方面 质量控制网络。