mHealth intervention for ART adherence and sexual risk reduction among HIV+ YMSM

移动健康干预对 HIV YMSM 中 ART 依从性和性风险的降低

• 批准号: 9111981
• 负责人: Nadia L Dowshen
• 金额: $ 17.02万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111981
• 关键词: AIDS/HIV problem; Address; Adherence; Adolescent; Adolescent Medicine; Adopted; Affect; Age; Attitude; Award; Behavior; Behavior Therapy; Behavioral; Big Data; Car Phone; Cellular Phone; Characteristics; Clinic; Clinical; Clinical Services; Complement; Consensus; Data; Decision Making; Delphi Study; Development; Diagnosis; Elements; Epidemic; Failure; Feedback; Focus Groups; Foundations; Future; Guidelines; HIV; HIV Infections; Health; Health Technology; Health behavior; Health behavior change; Incentives; Incidence; Incubators; Individual; Infection; Inflammation; Internet; Intervention; Intervention Studies; Interview; Life; Location; Logistic Regressions; Longevity; Machine Learning; Measures; Mentors; Mentorship; Methodology; Outcome; Participant; Pediatric Hospitals; Pharmaceutical Preparations; Philadelphia; Population; Preceptorship; Prevention strategy; Preventive Intervention; Process; Public Health; Qualitative Research; Reporting; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Priority; Risk; Risk Reduction; Secondary Prevention; Services; Sexual Health; Sexually Transmitted Diseases; Social Network; Specialist; Structure; Techniques; Technology; Testing; Time; Training; Training Activity; Viral; Work; Youth; adolescent health; adolescent health outcomes; adolescent sexual health; antiretroviral therapy; base; career development; clinical care; co-infection; demographics; design; epidemiologic data; experience; follow-up; high risk; improved; innovation; mHealth; medication compliance; men; mobile application; mobile computing; multidisciplinary; patient oriented; prevent; programs; psychosocial; public health relevance; reproductive tract; satisfaction; sex; sex risk; sexual risk taking; skills; success; technology development; theories; therapy adherence; therapy development; tool; transmission process; usability; young man; young men who have sex with men

DESCRIPTION (provided by applicant): The candidate is an adolescent medicine specialist and Director of Adolescent HIV Services at The Children's Hospital of Philadelphia with a research focus on using mobile technology to improve adherence and other health outcomes for adolescents at risk for and living with HIV/AIDS. The candidate proposes a career development program that will provide her with the skills and experience to become an independent investigator in the field of adolescent HIV research. In addition to didactic coursework in quantitative and qualitative research methodology and health behavior theory, the candidate's career development will be guided by a multidisciplinary team of nationally recognized advisors committed to her success. [She will form a Technology Advisory Board for mentorship and preceptorships in all aspects of mobile health (mHealth) technology, including incubation and development of technology-based health interventions, study design and analysis techniques for big data/machine learning, gamification theory, user interface/responsive design techniques, usability testing, and the application of health behavior theory to develop mHealth interventions.] Career development activities will be complemented by practical experience gained through the conduct of original research. This proposal examines key health behaviors of medication adherence and sexual risk among young men who have sex with men (YMSM) living with HIV/AIDS, and proposes to develop a mobile phone based intervention targeted at improving these health behaviors in the real times and places youth need support. AIM 1 will describe the incidence of STI co-infections and virologic failure and report the standardized risk of these outcomes across strata of HIV+ YMSM through retrospective chart review augmented by in-depth structured interviews for further understanding of key psychosocial and behavioral factors. Using focus groups of youth at high- and low-risk, selected based on findings from AIM 1, AIM 2 will explore how HIV+ YMSM use mobile technology, and their attitudes towards various mobile phone-based tools to improve adherence and reduce sexual risk. Delphi methodology will first be used in AIM 3 to convene a panel of mHealth and adolescent health experts to establish consensus guidelines for adolescent sexual health technology-based intervention development. These results, combined with youth input from AIM 2, will serve as a guiding framework for development of a new mHealth secondary prevention intervention for HIV+ YMSM. The new mHealth intervention composed of theory-driven elements, for example, including time and location-based reminders, and individual and group-based gaming incentives will then undergo usability testing consisting of (a) a focus group for specific feedback on design and user experience and then (b) a 12-month feasibility trial where 20 youth will have the application installed and usage, satisfaction, and clinical outcome data will be collected. In line with NIMH's research priorities, this proposal sets out to develop an innovative secondary prevention strategy targeting improved medication adherence and sexual risk reduction among HIV+ YMSM.

描述（由申请人提供）：候选人是费城儿童医院的青少年医学专家兼青少年艾滋病毒服务总监，研究重点是利用移动技术来改善有艾滋病毒/艾滋病风险和生活的青少年的依从性和其他健康成果。候选人提出了一项职业发展计划，该计划将为她提供技能和经验，以成为青少年艾滋病毒研究领域的独立研究者。除了定量和定性研究方法论和健康行为理论的教学课程外，候选人的职业发展还将受到一支多学科的全国认可顾问团队的指导，致力于她的成功。 [她将在移动健康（MHealth）技术的各个方面成立一个技术咨询委员会，包括基于技术的健康干预措施的孵化和开发，用于大数据/机器学习，游戏理论，用户/响应式设计技术，可用性测试以及健康行为理论在开发MHEATHEALTH INTEFERTIONS的应用程序的应用。 通过进行原始研究获得的实践经验将为职业发展活动提供补充。该提案研究了与男性发生性关系（YMSM）患有艾滋病毒/艾滋病的年轻人的药物遵守和性风险的关键健康行为，并建议开发一种基于手机的干预措施，该干预旨在在现实时代改善这些健康行为，而青年人需要支持。 AIM 1将描述性传播感染共同感染和病毒学失败的发生率，并通过回顾性图表审查通过回顾性图表审查来报告这些结果的标准化风险，并通过深入的结构化访谈增强，以进一步了解关键的心理社会和行为因素。根据AIM 1的发现，使用高风险和低风险的青年焦点小组，AIM 2将探讨HIV+ YMSM如何使用移动技术及其对各种基于手机的工具的态度，以提高依从性和降低性风险。 Delphi方法论将首先用于AIM 3，以召集MHealth和Adborcent Health专家小组，以建立基于性健康技术的基于性健康的干预开发的共识指南。这些结果以及AIM 2的青年投入将成为开发HIV+ YMSM新的MHealth二级预防干预措施的指导框架。例如，由理论驱动的元素组成的新的MHealth干预措施，包括基于时间和位置的提醒，以及基于小组的游戏激励措施，将经过可用性测试，包括（a）（a）一个针对设计和用户体验的特定反馈的焦点小组，然后（b）（b）20个月的可行性试验将20岁的青年安装和用途，并将其安装和用法满足，并进行满足，并启动临床。与Nimh的 研究重点，该提案旨在制定针对艾滋病毒+ YMSM的药物依从性和性风险降低的创新次级预防策略。