Pathways from Childhood Self-Regulation to Cardiovascular Risk in Adolescence

从童年自我调节到青春期心血管风险的途径

基本信息

批准号：
8838220
负责人：
Lilly Shanahan
金额：
$ 84.93万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-14 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8838220
关键词：
Adolescence Adolescent Adult Age Alcohol or Other Drugs use Behavior Behavior assessment Behavioral Biological Markers Blood C-reactive protein Cardiovascular Diseases Cereals Child Psychology Child Rearing Childhood Chronic Disease Clinical Data Development Diet Habits Dietary intake Emotional Emotions Exercise Exercise Physiology Exhibits Fasting Foundations Funding Health Health behavior Hypertension Impulsivity Inflammation Informal Social Control Institution Insulin Intercept Interleukin-1 Interleukin-6 Life Life Cycle Stages Lipids Longitudinal Studies Measurement Measures Mediating Metabolic Metabolic syndrome Methods Modeling Morbidity - disease rate Obesity Pathway interactions Persons Physical activity Physiological Physiology Poverty Prevention Preventive Intervention Principal Investigator Reporting Research Resources Risk Scientist Serum Markers Sex Characteristics Sleep Staging TNF gene Testing United States National Institutes of Health Work Youth base biobehavioral measurement blood lipid cardiovascular risk factor cost effective disorder risk fasting glucose glucose metabolism heart rate variability inflammatory marker meetings mortality nutrition prevent programs psychosocial racial difference waist circumference

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular risk factors (CVR)-including obesity, elevated lipids, altered glucose metabolism, hypertension, and elevated low-grade inflammation-are detectable, common, and increasing during adolescence. However, the developmental origins of adolescent CVR and its increases are poorly understood. Research on adults suggests that CVR is concentrated among those who had poor self-regulation in childhood, including difficulties in regulating their behaviors (e.g., impulsivity), emotions (e.g. negative emotion), and/or physiology (e.g., heart rate variability) during situations of challenge. Here we propose to test whether trajectories of self-regulation extending from ages to 2 to 10 predict trajectories of CVR during adolescence (ages 16, 17, 18). We also propose to test whether childhood self-regulation adolescent CVR pathways are mediated by health behaviors (e.g., substance use, exercise, nutrition, and sleep). By testing these linkages, the proposed research will be the first to conduct a fine-grained developmental analysis of childhood self-regulation health behaviors CVR pathways spanning 16 years. We have assembled an interdisciplinary team of scientists from Developmental, Clinical, and Quantitative Psychology, Pediatrics, Exercise Physiology, and Nutrition and draw on resources from two neighboring academic institutions. Furthermore, we propose to leverage a valuable extant scientific resource: an ongoing 15-year longitudinal study that has already collected extensive data on self-regulation and psychosocial adversity at ages 2, 4, 5, 7, and 10 and will collect these data again at ages 15 and 17. The proposed project adds the measurement of indicators of CVR, including serum markers, and also in-depth measurements of health behaviors, specifically substance use, physical activity, dietary habits and intake, and sleep at ages 16, 17, and 18. Thus, funding requested in this proposal would expand and enhance the ongoing longitudinal study through the examination of past and current measures plus additional metabolic (e.g., blood lipids, fasting glucose, insulin) and inflammatory markers (e.g., IL-1, IL-6 TNF-¿, hs-CRP) and health behavior assessments for approximately 200 adolescents. Results will provide a foundation for informing the early prevention of CVR, and for building a larger program of research on early self-regulation and its implications for disease risk during the early life course.

描述（由申请人提供）：心血管危险因素（CVR）——包括肥胖、血脂、葡萄糖代谢改变、高血压和轻度炎症升高——在青春期是可检测到的、常见的和增加的。然而，青少年CVR的发育起源。对成年人的研究表明，CVR 集中在那些童年时期自我调节能力较差的人，包括难以调节自己的行为（例如冲动）和情绪（例如消极情绪）。挑战情况下的情绪）和/或生理（例如心率变异性）。在这里，我们建议测试从 2 岁到 10 岁的自我调节轨迹是否可以预测青春期（16、17、18 岁）的 CVR 轨迹。我们还建议测试儿童自我调节青少年 CVR 路径是否由健康介导。通过测试这些联系，拟议的研究将首次对儿童自我调节健康进行细粒度的发展分析。行为 CVR 途径跨越 16 年。我们组建了一支由来自发育、临床和定量心理学、儿科、运动生理学和营养学的科学家组成的跨学科团队，并利用两个邻近学术机构的资源。科学资源：一项持续 15 年的纵向研究，已经收集了 2、4、5、7 和 10 岁儿童自我调节和社会心理逆境的大量数据，并将在15岁和17岁。拟议的物质项目增加了CVR指标的测量，包括血清标记物，以及对健康行为的深入测量，特别是16岁、17岁的使用、体力活动、饮食习惯和摄入量以及睡眠， 18. 因此，本提案中要求的资金将通过检查过去和当前的措施以及额外的代谢（例如血脂、空腹血糖、胰岛素）和炎症标志物（例如 IL-1、对大约 200 名青少年进行的 IL-6 TNF-¿、hs-CRP）和健康行为评估结果将为 CVR 的早期预防以及建立更大的早期自我调节研究计划奠定基础。及其对早期疾病风险的影响生命历程。