Department of Veterans Affairs Rehabilitation Research & Development Center for Limb Loss and MoBility (CLiMB)

退伍军人事务部康复研究部

• 批准号: 10349233
• 负责人: Glenn Klute
• 金额: --
• 依托单位: VA PUGET SOUND HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2027-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349233
• 关键词: 3D Print; Acceleration; Achievement; Amputation; Area; Basic Science; Biomechanics; Biometry; Caring; Clinical; Clinical Management; Clinical Practice Guideline; Clinical Research; Collaborations; Computer Models; Decision Aid; Development; Device or Instrument Development; Devices; Disease; Engineering; Ensure; Epidemiologist; Epidemiology; Evidence based treatment; Evolution; Future; Image; Impairment; Industry; Injury; International; Intervention; Knowledge; Laboratories; Leadership; Lower Extremity; Medical; Mission; Motion; Musculoskeletal; Operative Surgical Procedures; Orthopedics; Orthotic Devices; Pathway interactions; Patients; Phase; Physicians; Prevention; Principal Investigator; Prosthesis; Provider; Rehabilitation therapy; Research; Research Design; Research Personnel; Resources; Risk; Scientist; Services; Structure; Techniques; Training; Translating; Translations; Trauma; Underrepresented Minority; United States Department of Veterans Affairs; Veterans; Woman; Work; active duty; clinical care; clinical translation; cohort; commercialization; comorbidity; disability; effective therapy; engineering design; experience; functional outcomes; healing; human subject protection; innovation; limb loss; mobility aid; multidisciplinary; new technology; next generation; novel strategies; pain reduction; personalized approach; point of care; preservation; prevent; prototype; rehabilitation research; rehabilitation science; rehabilitation strategy; research and development; shared decision making; simulation; success; support tools; tool; treatment strategy

CENTER SUMMARY/ABSTRACT The mission of the Center for Limb Loss and MoBility (CLiMB) is to preserve, restore, and enhance functional mobility, independence, and participation in Veterans with lower limb loss or other musculoskeletal impairments. CLiMB serves Veterans with mobility disabilities arising from medical comorbidities or post-service trauma, as well as those with injuries sustained while on active duty, including small but important cohorts of women and other under-represented minorities. CLiMB accomplishes this mission by conducting innovative and rigorous research; disseminating discoveries to Veteran patients and providers, VA leadership, and other stakeholders; and translating knowledge and devices into clinical care. CLiMB’s nationally and internationally recognized Principal Investigators are a multidisciplinary group of clinician-scientists, engineers, biomechanists, and epidemiologists. The Center’s scientific approaches and research Focus Areas span basic science, through engineering design and development, to applied clinical research. CLiMB’s research Focus Areas are rooted in the parallel importance of studying (1) Prevention of impairment onset and progression, (2) Innovative mobility device development, (3) Evidence-based treatment and rehabilitation interventions, and (4) Personalized surgical and prosthetic/orthotic treatment interventions. Focus Area projects are conceived through a synergistic collaboration with patients, clinicians, clinician-scientists, and scientists both within and outside the Center who identify and define unmet clinical needs in our Veteran patients. Project success is achieved through CLiMB’s clinical translational pathway where projects often begin in a Discovery or Innovation phase and culminate in clinical Translation. Consequently, the Center has placed a significant emphasis on ensuring that its research and innovations have a demonstrated clinical need and a pathway to translation to ensure that Veterans benefit directly from its work. CLiMB Translation can take on different forms (knowledge and devices) including evidence to support clinical practice guidelines, physician decision support tools, patient decision aids available at the point of care, and collaborations with industry to commercialize devices that are made available to Veterans. CLiMB’s success and achievements are the result of unique laboratory and intellectual resources that cut across our Focus Areas. These Core resources accelerate and facilitate the collaborative work of internationally renowned clinicians and scientists with complementary expertise in rehabilitation science, engineering, and clinical care. These resources have been cultivated by our Center for years, and with this renewal we are further formalizing their structure, leadership, and purpose to include the following seven Cores: (1) Biomechanics & Basic Science, (2) Imaging & Motion Analysis, (3) Computational Modeling, (4) Rapid Prototyping, (5) Clinical Study Design, Epidemiology, & Biostatistics, (6) Novel Technologies & Applications, and (7) Administration & Protection of Human Subjects. CLiMB’s future work will take a major step forward based upon the interim evolution of engineering discoveries, unique to CLiMB resources, and the emergence of validated innovation and decision support tools. In 2021, the Center has ten PIs who are committed to finding new ways of treating Veterans with lower limb loss or other musculoskeletal impairments and translating these findings to the point of Veteran care. Its planned innovative studies will harness novel technologies and applications including: the unique aspects of 3D printing, musculoskeletal simulation, and prosthetic emulation to develop novel and personalized approaches to prosthetic/orthotic prescription; state-of-the-art imaging and motion analysis techniques to understand and treat orthopedic maladies; decision support tools for amputation-level shared decision making to maximize functional outcomes; and cutting edge rehabilitation strategies to optimize healing and reduce pain. CLiMB will accomplish this mission while continuing its commitment to the training of the next generation of investigators.

中心概要/摘要 肢体丧失和活动中心 (CLiMB) 的使命是保护、恢复和增强肢体功能 下肢丧失或其他肌肉骨骼损伤的退伍军人的活动能力、独立性和参与度。 CLiMB 为因医疗合并症或服役后创伤而导致行动不便的退伍军人提供服务， 以及那些在现役期间受伤的人，其中包括一小部分但很重要的妇女和 其他代表性不足的少数群体通过创新和严格的方式完成这一使命。 研究；向退伍军人患者和提供者、退伍军人管理局领导层和其他利益相关者传播研究结果； 将知识和设备转化为 CLiMB 国内和国际认可的临床护理。 首席研究员是一个由临床科学家、工程师、生物力学专家和 该中心的科学方法和研究重点领域涵盖基础科学， CLiMB 的研究重点领域植根于工程设计和开发、应用临床研究。 研究 (1) 预防损伤的发生和进展，(2) 创新流动性的并行重要性 设备开发，(3) 循证治疗和康复干预，以及 (4) 个性化 手术和假肢/矫形器治疗干预重点领域项目是通过协同来构思的。 与患者、临床医生科学家以及中心内外的科学家合作 识别并定义我们的退伍军人患者未满足的临床需求 项目的成功是通过 CLiMB 实现的。 临床转化途径，项目通常从发现或创新阶段开始，并以 经审查，该中心非常重视确保其研究。 和创新具有明确的临床需求和转化途径，以确保退伍军人受益 直接来自其工作的 CLiMB 翻译可以采取不同的形式（知识和设备），包括证据。 支持临床实践指南、医生决策支持工具、患者决策辅助工具 护理点，以及与行业合作，将提供给退伍军人的设备商业化。 CLiMB 的成功和成就是跨领域的独特实验室和智力资源的结果 我们的重点领域。这些核心资源加速并促进国际协作工作。 在康复科学、工程和康复领域具有互补专业知识的知名科学家 这些资源是我们中心多年来积累的，通过这次更新，我们进一步发展。 正式确定其结构、领导力和目的，包括以下七个核心：(1) 生物力学和 基础科学，(2) 成像与运动分析，(3) 计算建模，(4) 快速原型设计，(5) 临床 研究设计、流行病学和生物统计学，(6) 新技术和应用，以及 (7) 管理和 CLiMB 未来的工作将在此基础上向前迈出一大步。 CLiMB 资源独有的工程发现的演变以及经过验证的创新的出现 到 2021 年，该中心将有 10 名 PI 致力于寻找新的治疗方法。 患有下肢丧失或其他肌肉骨骼损伤的退伍军人，并将这些发现转化为 其计划的创新研究将利用新技术和应用，包括： 3D 打印、肌肉骨骼模拟和假肢仿真的独特方面可开发新颖且 最先进的成像和运动分析的个性化方法； 理解和治疗骨科疾病的技术，用于放大级共享的决策支持工具； 最大化功能结果的决策；以及优化康复的尖端康复策略 CLiMB 将完成这一使命，同时继续致力于下一次的培训。 一代研究者。