Clinical Imaging

临床影像

基本信息

批准号：
8830227
负责人：
EDWARD E. PARTRIDGE
金额：
$ 22.65万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8830227
关键词：
Advocate Aliquot Area Authorization documentation Bar Codes Basic Science Blood Cancer Center Clinic Clinical Clinical Protocols Clinical Trials Code Collection Comprehensive Cancer Center Consent Consult Consultations Data Databases Development Diagnostic Drug or chemical Tissue Distribution Ensure Environment Ethics Family Freezing Funding Funding Agency Goals Grant Health Insurance Portability and Accountability Act Histology Human Image Informed Consent Lesion Liquid substance Malignant Neoplasms Medical Methodology Neoadjuvant Therapy Paraffin Pathologist Pathology Patients Play Privacy Procedures Process Protocols documentation Publications Pyroxylin Quality Control Recording of previous events Research Research Personnel Research Project Grants Role Saliva Sampling Secondary to Services Silver Site Slide Social Welfare Specimen Specimen Handling Staining method Stains Tissue Banking Tissue Banks Tissue Donors Tissue Microarray Tissue Procurements Tissue Sample Tissues Translational Research University of Alabama at Birmingham Cancer Center Urine Writing anticancer research base biobank cancer Biomedical Informatics Grid diagnosis quality diagnostic accuracy experience human tissue laser capture microdissection meetings neoplastic new technology programs quality assurance social tissue processing tissue resource tumor

项目摘要

The goal of the UAB Comprehensive Cancer Center Tissue Procurement Shared Facility (TPSF) is to assure that relevant human tissues, both normal and cancer, are available for CCC investigators. The TPSF accomplishes this by supporting the collecting, processing, storing, and supplying of a wide range of human tissues. Neoplastic and control tissues are supplied as fresh, frozen, paraffin-processed specimens or tissue sections and other histology services are provided as requested by the users of the facility. Also, bodily fluids and fluid components can be provided. The number of investigators requesting tissue sections in lieu of other forms of tissue continues to grow. The facility also offers microdissected specimens and the construction of tissue arrays. Pathologists evaluate all tissues supplied for research for quality and diagnostic accuracy. The facility will continue to play a very active role in promoting the goals of the Cancer Center and the needs of investigators of cancer, most especially in enabling the effective use of emerging methodologies in basic and translational research, coordinating human tissue utilization in clinical trials, and ensuring compliance in the changing regulatory environment. TPSF's ability to meet tissue needs is assured by recent renovations and the ongoing participation of the staff in educational programs and active research in the area of tissue processing and banking. The TPSF has participated in the development of a comprehensive database and bar-coding system that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements, and usage of the tissues by researchers. Between January and December 2009 the facility provided 53 UAB investigators with 562 fresh or frozen human tissue samples, 1966 paraffin blocks, and 13,577 slides. Since 1978, the facility has provided approximately 150,000 tissue specimens, blocks, and slides to investigators at UAB. These tissues have been used in a total of 1,175 publications.

UAB综合癌症中心组织采购共享设施（TPSF）的目标是确保 CCC研究人员可以使用相关的人体组织，无论是正常和癌症。 TPSF 通过支持广泛的人类的收集，加工，存储和供应来实现这一目标组织。肿瘤组织和对照组织作为新鲜，冷冻，石蜡加工标本或组织提供根据设施的用户要求提供部分和其他组织学服务。另外，体液可以提供流体成分。要求组织部分代替的调查人员数量其他形式的组织继续增长。该设施还提供了微区的标本，构造组织阵列。病理学家评估提供质量研究的所有组织诊断准确性。该设施将继续在促进癌症中心的目标和需求方面发挥非常积极的作用癌症研究者，尤其是在基本中有效使用新兴方法和翻译研究，协调临床试验中的人体组织利用，并确保合规不断变化的监管环境。最近的翻新可以确保TPSF满足组织需求的能力以及员工在组织领域的教育计划和积极研究的持续参与处理和银行业务。 TPSF参与了综合数据库的开发通过合并组织供体，组织的信息来支持组织资源的条形码系统诊断和质量控制，组织加工和存储，研究者组织需求以及使用研究人员的组织。在2009年1月至12月之间，该设施提供了53名UAB调查人员有562个新鲜或冷冻的人体组织样品，1966年的石蜡和13,577张幻灯片。自1978年以来设施为UAB的研究人员提供了大约150,000个组织标本，块和幻灯片。这些组织已在总共1,175个出版物中使用。