The role of sweet taste genes in postingestive endocrine responses to sweeteners

甜味基因在食后内分泌对甜味剂的反应中的作用

基本信息

批准号：
8411540
负责人：
ALEXANDER A BACHMANOV
金额：
$ 7.66万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-10 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8411540
关键词：
Academy Acids Affect Alleles Amino Acids Behavior Behavioral Beverages Blood Brain Breeding Candidate Disease Gene Chromosome Mapping Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 9 Collaborations Complement Congenic Mice Congenic Strain Consumption Digestion Disease Endocrine Ethanol Feeding behaviors Flavoring Food GNAI2 gene Genes Genetic Genetic Variation Genome Glucose Glycine Goals Grant Health Hormones Human Hypertension Inbred Mouse Inbred Strain Inbred Strains Mice Inbreeding Individual Institutes Insulin Intake Knock-out Link Maps Metabolic syndrome Metabolism Molecular Monitor Mouse Strains Mus Nutrient Obesity Organ Orthologous Gene Phenotype Physiological Physiology Principal Investigator Process Proteins Quantitative Trait Loci Receptor Gene Research Resolution Rewards Role Russia Saccharin Science Scientist Site Staging Stimulus Sucrose Surveys Sweetening Agents Taste Bud Cell Taste Buds Taste Perception Techniques Testing Tissues United States United States National Institutes of Health Variant base consomic detection of nutrient economic impact follow-up food consumption gene cloning genetic linkage analysis genetic variant glucagon-like peptide 1 hormone metabolism improved mouse model novel null mutation parent grant parent project positional cloning preference programs receptor research study response sensory system sugar sweet taste perception therapy design

项目摘要

DESCRIPTION (provided by applicant): Taste is the primary sensory system that determines whether a food or beverage will be ingested or rejected. Taste also influences the digestion and metabolism of food. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake of nutrients and modulate the excesses of consumption that contribute to diseases such as obesity, hypertension and the metabolic syndrome. These diseases pose serious problems for human health and have major negative economic impact worldwide, including in the United States and Russia. The long-term goal of the parent project is to positionally clone genes involved in taste and ingestive behavior. This involves developing genetically defined mouse models for genetic mapping and mechanistic studies. This FIRCA proposal will expand these studies to examine the role of sweet taste genes in postingestive endocrine responses to sweeteners. The proposed studies will aid in gene identification in mice, which will reveal the function of their human orthologs and their role in taste-related human behavior. This project will support collaboration between scientists at the Monell Center and the Pavlov Institute and will help to build research capabilities at the Pavlov Institute. The propose research will be done primarily in Russia at the Pavlov Institute of Physiology of the Russian Academy of Sciences in collaboration with Dr. Zolotarev as an extension of NIH grant R01DC000882 (09/19/2008 - 08/31/2013). PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

描述（由申请人提供）：味道是决定食物或饮料是否被摄入或拒绝的主要感官系统。味觉还影响食物的消化和代谢。因此，了解这种感觉背后的机制对于我们控制营养摄入和调节导致肥胖、高血压和代谢综合征等疾病的过度摄入的能力至关重要。这些疾病给人类健康带来严重问题，并对包括美国和俄罗斯在内的全世界经济产生重大负面影响。父项目的长期目标是定位克隆涉及味觉和摄取行为的基因。这涉及开发用于基因图谱和机制研究的基因定义的小鼠模型。 FIRCA 的这项提案将扩展这些研究，以检验甜味基因在食后内分泌对甜味剂的反应中的作用。拟议的研究将有助于小鼠的基因鉴定，这将揭示其人类直系同源物的功能及其在与味觉相关的人类行为中的作用。该项目将支持莫内尔中心和巴甫洛夫研究所的科学家之间的合作，并将有助于增强巴甫洛夫研究所的研究能力。拟议的研究将主要在俄罗斯科学院巴甫洛夫生理学研究所与 Zolotarev 博士合作进行，作为 NIH 拨款 R01DC000882（2008 年 9 月 19 日 - 2013 年 8 月 31 日）的延伸。 PHS 398/2590（修订版 09/04，重新发布 4/2006）页面延续格式页面