Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors

完整项目 1：LSR 改变代谢信号以驱动侵袭性乳腺癌行为

基本信息

批准号：
9152333
负责人：
Jodie Michelle Fleming
金额：
$ 18.9万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9152333
关键词：
Address Advanced Malignant Neoplasm African American Anabolism Behavior Binding Bioenergetics Biological Biological Assay Breast Cancer Cell Cancer Biology Caucasians Cell division Cell physiology Cholesterol Chronic Clinical Collaborations Community Outreach Comprehensive Cancer Center Cytoplasmic Tail Data Diagnosis Diet Disease Distant Metastasis Education Education and Outreach Educational process of instructing Endocytosis Energy-Generating Resources Environment Event Faculty Fatty acid glycerol esters Foundations Funding Gene Chips Genes Genomics Glycogen Goals Guanosine Triphosphate Phosphohydrolases Health Sciences Hepatic High Fat Diet Histopathology In Vitro Incidence Institution Lead Leptin Link Lipids Lipolysis Lipoprotein Receptor Lipoproteins Malignant - descriptor Malignant Neoplasms Mammary Neoplasms Measures Mediating Membrane Membrane Lipids Mentorship Metabolic Metabolic syndrome Metabolism Minority Minority Graduate Student Molecular Morbidity - disease rate Mus Neoplasm Metastasis North Carolina Nuclear Obesity Observational Study Outcome Outreach Research Pathway interactions Patient-Focused Outcomes Phenotype Pilot Projects Population Population Sciences Positioning Attribute Prevalence Property Proteins Public Health Race Recurrence Regulation Research Research Infrastructure Research Training Resistance Resources Role Scientist Signal Pathway Signal Transduction Signaling Molecule Statistical Models Students Testing Tight Junctions Tumor Subtype UNC Lineberger Comprehensive Cancer Center Universities Variant Woman Work Xenograft procedure anticancer research base cancer education cancer health disparity cancer stem cell cancer subtypes career caucasian American cell behavior community intervention feeding glucose uptake health disparity health equity improved in vivo insight interest lipid metabolism lipid transport malignant breast neoplasm meetings metabolomics minority health minority undergraduate mortality novel obesogenic overexpression population based racial disparity receptor expression receptor function research study response rho rho GTP-Binding Proteins therapeutic development tumor tumor progression tumorigenesis tumorigenic uptake

项目摘要

The North Carolina Central University (NCCU) and the Lineberger Comprehensive Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue their effective and mutually beneficial partnership focusing on African-American health disparities. During the past 13 years NCI funding has firmly established the Partnership building on complementary institutional strengths, conducting molecular and population-based cancer research and training of junior faculty and students. This Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) application builds upon the foundation already established through the previous U54 funding to meet the challenge of disparities in cancer incidence and mortality in North Carolina and the US through cancer research, education and community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU providing NCCU scientists mentorship and collaborative opportunities to compete for NCI grantst; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying the disproportionate incidence of cancer mortality and morbidity between African Americans and Caucasian Americans, using both molecular and population-based approaches; (3) increase the number of NCCU scientists focused on cancer research as well as the education of minority undergraduate and graduate students in cancer research; (4) increase the faculty at the UNC LCCC focused on minority disparities research; and (5) create long-term collaborations between basic, public health, and translational scientists from NCCU and UNC LCCC. The strengths of each institution are uniquely positioned to overcome the weaknesses found in the other to achieve these priorities. Specific collaborative components of the proposal include: Two full and one pilot projects in community intervention and population science, one full and one pilot project in basic/translational cancer research in diseases with a higher incidence in African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The partnership combines the expertise and resources of LCCC in population/public health sciences emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and NCCU’s demonstrated interest and facilty with minority health disparities research particularly in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the emphasis on reaching minority populations and developing the careers of , faculty and students. These complementary institutional strengths will assure that the Partnership builds the infrastructure necessary for a lasting collaborative research, effective community outreach and a substantial contribution to our understanding of minority disparities..

北卡罗来纳州中央大学（NCCU）和Lineberger综合北卡罗来纳大学教堂山（UNC-CH）的癌症中心（LCCC）将继续他们的有效和互惠互利的伙伴关系专注于非裔美国人健康差异。在过去的13年中，NCI资金首先建立了合作伙伴关系基于完整的机构优势，进行分子和基于人群初级教师和学生的癌症研究和培训。这种全面的合作伙伴关系 Advance Cancer Health平等（CPACHE）应用程序已经建立在基础上通过以前的U54资金建立，以应对癌症差异的挑战北卡罗来纳州和美国的发病率和死亡率通过癌症研究，教育和社区宣传。我们的目标是：（1）增强NCCU的癌症研究能力为NCCU科学家提供精力和协作机会，以争夺NCI Grantst; （2）丰富了NCCU和LCCC进一步探索机制的能力非洲裔美国人之间癌症死亡率和发病率的不成比例的事件以及使用分子和基于人群的方法的高加索美国人；（3）增加了专注于癌症研究的NCCU科学家的数量以及对癌症研究的少数群体本科生和研究生；（4）增加教师 UNC LCCC专注于少数民族差异研究；（5）建立长期合作在NCCU和UNC LCCC的基本，公共卫生和翻译科学家之间。这每个机构的优势都具有独特的位置，以克服在其他以实现这些优先事项。该提案的特定协作组成部分包括：社区干预和人口科学领域的两个完整和一个试点项目，一个完整，一个疾病基本/转化癌症研究的试点项目，较高的事件非裔美国人和3个核心：外展，研究教育和组织病理学。这合作伙伴关系结合了LCCC在人群/公共卫生科学中的专业知识和资源强调北卡罗来纳州，基因组学，癌症生物学和癌症教育的分布以及 NCCU对少数族裔健康差异研究表现出兴趣和兴趣，尤其是在北卡罗来纳州达勒姆（Durham NC）中强调接触少数群体，并发展教职员工和学生的职业。这些完整的机构优势将确保伙伴关系建立持久协作研究，有效的社区外展和对我们对少数分配的理解做出了重大贡献。