Aging Auditory System: Presbycusis and Its Neural Bases

听觉系统老化：老年性耳聋及其神经基础

• 批准号: 9011244
• 负责人: Robert D Frisina
• 金额: $ 180.65万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9011244
• 关键词: Acoustics; Affect; Age; Aging; Aldosterone; Animal Model; Animals; Arthritis; Auditory; Auditory system; Behavioral; Biological Markers; Biological Neural Networks; Biological Response Modifier Therapy; Brain; Cardiovascular Diseases; Chronic; Clinical; Clinical Trials; Communication impairment; Custom; Development; Ear; Elderly; Environment; Evaluation; Exposure to; Goals; Hearing; High Prevalence; Hormonal; Hormones; Human; Intervention; Investigation; Lead; Link; Measurement; Measures; Medical; Methods; Molecular; Mus; Nerve Degeneration; Nervous system structure; Neural Inhibition; Neuronal Plasticity; Neurons; Noise; Outcome Measure; Peripheral; Pharmaceutical Preparations; Physiological; Play; Presbycusis; Prevention; Process; Research; Role; Serum; Speech; Supplementation; Techniques; Testing; Theoretical model; Therapeutic; Time; Work; age related; aged; aging population; base; catalyst; dosage; experience; hearing impairment; hormone therapy; human subject; improved; indexing; innovation; insight; instrument; novel; prevent; public health relevance; relating to nervous system; research study; response; sound; speech processing; young adult

 DESCRIPTION (provided by applicant): Our long-term goal is to ameliorate the debilitating consequences of age-related hearing loss (ARHL) or presbycusis. ARHL is the number one communication disorder and number one neurodegenerative condition of our expanding aging population. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and difficulty understanding speech in noise. While ARHL is one of the top three chronic medical conditions of the elderly, there currently are no approved medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). Despite decades of research and discovery, overcoming the barriers of ARHL through prevention and treatment continues to represent a major scientific and clinical challenge. The thematic focus of this application is modulation of presbycusis through biotherapeutics and targeted induction of neural plasticity. An important feature of these approaches is elucidating the related roles of peripheral function and central auditory plasticity in auditory processing. This pioneering research uses innovative catalysts to induce functional changes in the aging auditory system. We target the primary consequences of ARHL using an array of measurement techniques in animal and human subjects. Insights gained from the evaluation of current theoretical models and project-specific hypotheses will play a prominent role in guiding development of new behavioral, technological and medical treatments aimed at slowing or preventing the progression of ARHL. Specific Aim 1. Determine the degree to which hormonal supplementation can prevent or slow the progression of ARHL. Experimental approach: Serum aldosterone and other related metrics and biomarkers will be quantitatively measured along with behavioral, physiological, and molecular indices, including peripheral and central hearing measures, in aging subjects undergoing aldosterone hormone therapies. Specific Aim 2. Determine the ability of enriched acoustic environments to ameliorate presbycusis. Experimental approach: Enriched acoustic environments will consist of extended, controlled exposure to specific artificially generated sounds presented in the free field in the animal holding environment (mouse vivarium facility) and via custom ear-level hearing instruments in humans. Outcome measures will index peripheral and central components of key features and biomarkers of ARHL. Specific Aim 3. Determine relations between brain plasticity and ARHL in older humans and animals, including the neural and molecular mechanisms that are involved. Experimental approach: We will build upon work indicating that reduced central inhibition and/or plastic changes in cortical activity ar key components of ARHL. A major focus of experiments will be the link between ARHL and central neural inhibition and excitation, particularly in older human and animal subjects.

 描述（通过应用程序证明）：我们的长期目标是划定与年龄相关的听力损失的令人衰弱的后果（ARHL）。在听觉敏感性的逐渐下降和差异性的噪声中，HL是老年人听力损失的三个慢性条件之一（ARHL其他类型）。和临床挑战。从评估模型中获得的洞察力将在指导行为，技术和医学的发展方面发挥着重要作用其他相关的指标和生物标志物将与行为一起定量，分子幼体，包括静脉和中心听力措施，吸引受试者醛固酮激素疗法2。拥有Envarium设施的动物中的自由领域和通过人类的定制耳朵听证会。和动物，涉及的神经和分子机制。