Combined analysis of lung cancer among uranium miners

铀矿工人肺癌的综合分析

• 批准号: 9144368
• 负责人: DAVID B RICHARDSON
• 金额: $ 7.6万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9144368
• 关键词: Combined; analysis; lung; cancer; among

 DESCRIPTION (provided by applicant): The US Public Health Service initiated a research program in the 1950s on the health of US uranium miners employed in the Colorado Plateau. Occupational exposures in the early years of mine operation resulted in large excesses of mortality due to respiratory diseases that were readily-detected by classical epidemiological methods. These findings were highly influential for informing understanding of the carcinogenic effect of radon exposures in the US and abroad. Today, despite important reductions in occupational exposures, radon remains a leading cause of lung cancer, with potential for relatively high occupational exposures among workers in a wide range of settings including underground metal and non-metal mining, subway and utility tunnels, phosphate fertilizer plants, natural gas and oil piping facilities, oil refineries, and for people employed as radon remediation workers and water treatment workers. Other workplaces including schools, hospitals, and prisons also may have areas with high radon levels. To strengthen the basis for protection of contemporary workers from the carcinogenic effects of radon, and to improve compensation decisions for workers exposed in the past, we propose a pooled analysis of recently-updated cohorts of US underground miners. State-of-the-art statistical methods for longitudinal data analysis will be used to assess the effects of time-since- exposure, age-at-exposure, and attained age. In addition, we will examine the joint effects of radon and smoking in these cohorts, leveraging substantial gains in information on lung cancer among non-smokers provided by recent updates of these cohorts. Finally, because a causal interpretation of epidemiological findings is strengthened by evidence of reproducibility and consistency, we will assess the consistency of results derived from analysis of US underground miner cohorts with associations observed in other international cohorts by conducting a pooled analysis incorporating data from major cohorts of miners from Canada, the Czech Republic, Germany, France, and China. The findings of this research project, which will yield the most precise radon risk estimates reported to-date, are expected to have substantial impact on understanding of the effects occupational and environmental radon exposures.

 描述（由适用提供）：美国公共卫生服务局在1950年代就科罗拉多高原雇用的美国铀矿工的健康启动了一项研究计划。在矿山运营的早期，职业暴露导致由于呼吸道疾病而引起的大量过量死亡率，这些疾病很容易通过经典的流行病学方法检测。这些发现对了解美国和国外暴露的致癌作用的理解具有很大的影响。 Today, important reductions in occupational exposures, radon remains a leading cause of lung cancer, with potential for relatively high occupational exposures among workers in a wide range of settings including underlying metal and non-metal mining, subway and utility tunnels, phosphate fertilizer plants, natural gas and oil piping facilities, oil refineries, and for people employed as radon remediation 工人和水处理工作者。包括学校，医院和监狱在内的其他工作场所也可能具有高ra的区域。为了加强保护当代工人免受ra的致癌作用的基础，并改善了过去暴露的工人的薪酬决策，我们提出了对美国地下矿工最近升级的同伙的汇总分析。用于纵向数据分析的最先进的统计方法将用于评估时间暴露，暴露年龄和年龄的影响。此外，我们将研究这些队列中ra和吸烟的联合作用，利用这些同类群体最近更新提供的非吸烟者中肺癌的信息的大量收益。最后，由于对流行病学发现的因果解释是通过可重复性和一致性的证据来加强的，因此我们将评估通过对美国地下矿工同伙分析与其他国际同事观察到的关联的结果的一致性，通过对加拿大矿业公司的大型矿工进行编码的矿工数据，从而在其他国际人群中观察到的关联，来自加拿大，czech Republic，Dermany，France，France，France和China。该研究项目的发现将产生迄今为止报告的最精确的ra风险估计，预计将对了解占据和环境ra暴露的影响产生重大影响。

项目成果

Lifetime excess absolute risk for lung cancer due to exposure to radon: results of the pooled uranium miners cohort study PUMA.

由于接触氡而导致终生罹患肺癌的绝对风险过高：铀矿工队列研究 PUMA 的结果。

• DOI: 10.1007/s00411-023-01049-w
• 发表时间: 2024
• 期刊: Radiation and environmental biophysics
• 影响因子: 1.7
• 作者: Kreuzer,M;Sommer,M;Deffner,V;Bertke,S;Demers,PA;Kelly-Reif,K;Laurier,D;Rage,E;Richardson,DB;Samet,JM;Schubauer-Berigan,MK;Tomasek,L;Wiggins,C;Zablotska,LB;Fenske,N
• 通讯作者: Fenske,N

PUMA - pooled uranium miners analysis: cohort profile.

• DOI: 10.1136/oemed-2019-105981
• 发表时间: 2020-03
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Rage E;Richardson DB;Demers PA;Do M;Fenske N;Kreuzer M;Samet J;Wiggins C;Schubauer-Berigan MK;Kelly-Reif K;Tomasek L;Zablotska LB;Laurier D
• 通讯作者: Laurier D