K12 Career Development Program: Omics of Pediatric Lung Diseases in DC

K12 职业发展计划：华盛顿特区小儿肺部疾病组学

• 批准号: 9069941
• 负责人: Robert J Freishtat
• 金额: $ 31.19万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9069941
• 关键词: Address; Advisory Committees; Affinity; Applications Grants; Area; Bioinformatics; Biology; Biometry; Boxing; Child; Childhood; Clinical; Data; Data Sources; Disease; District of Columbia; Doctor of Philosophy; Educational Curriculum; Environment; Genetic; Genetic Medicine; Genomics; Goals; Grant; Health; Health Sciences; Laboratories; Lead; Learning; Lung; Lung diseases; Medical center; Medicine; Mentored Clinical Scientist Development Program; Mentors; Methodology; Minority Recruitment; Performance; Phenotype; Physicians; Principal Investigator; Proteomics; Research; Research Methodology; Research Personnel; SECTM1 gene; Scientist; Structure; Supervision; Systems Biology; Time; Training; Translating; United States National Institutes of Health; Universities; Washington; Work; base; career development; clinical phenotype; epigenomics; experience; medical schools; next generation sequencing; personalized medicine; pre-clinical; programs; skills; tool

DESCRIPTION (provided by applicant): We propose a K12 Career Development Program on Omics of Pediatric Lung Diseases DC based within the Department of Integrative Systems Biology (ISB), George Washington University School of Medicine and Health Sciences (GW), and fully commensurate with the Center for Genetic Medicine Research (GenMed) at Children's National Medical Center (CNMC) in Washington DC (ISB/GenMed) (see www.gwumc.edu/isbweb). Omics is a systems biology approach to biology in health and disease, and an underlying lynch pin for the emergence of 'personalized medicine'. Providing career development support in omics of lung diseases is timely and highly important for both physician/scientists and PhD scientists A fundamental problem is that systems biology approaches utilizing multi-level omics data sources are exceptionally multi-disciplinary, requiring the lung researcher to have working expertise in many areas of academic endeavor that were, previously, considered distinct (aka 'siloed'). The key challenge for K12 omics career development programs is to break down traditional siloes in academic medicine, providing a large research tool box to the Scholar that ranges from epigenomics, to bioinformatics of next-generation sequence data, to phenotype/environment interactions. Our K12 program responds to this need by providing time for Scholars to: 1) take coursework in omics and systems biology relevant to their research; 2) learn state-of-the art laboratory methodology in genomics, proteomics, and bioinformatics; 3) develop preliminary data under the supervision of a Lead Mentor and Mentoring Team that will lead to submission of an independent NIH grant application; and 4) learn to effectively translate their accomplishments to the improvement of pediatric lung diseases. In order to accomplish their goals the K12 Scholars will spend at least 75% effort honing these skills over a 1-3 year period of time, depending on past experience and topic area. During this period each of the above goals is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of a Lead Mentor. Our proposed K12 program draws 11 Lead Mentors and 16 secondary Mentors from the ISB/GenMed roster who will function as a Mentoring Team in four Affinity areas: Genetics and Genomics; Proteomics; Bioinformatics, and Clinical and Pre-Clinical Phenotyping. The administrative structure of the K12 includes two Co-Principal Investigators with complementary expertise in omics and lung biology/diseases who will serve as Program Director and Career Development Director, respectively, a Director of Minority Recruitment, and internal and external advisory committees. We propose to select and train a total of 2-4 K12 Scholars during a 5 year grant period.

描述（由申请人提供）：我们提议在乔治华盛顿大学医学与健康科学学院 (GW) 综合系统生物学系 (ISB) 内开展一项关于 DC 儿科肺部疾病组学的 K12 职业发展计划，并且完全符合华盛顿特区儿童国家医疗中心 (CNMC) 的遗传医学研究中心 (GenMed) (ISB/GenMed)（参见 www.gwumc.edu/isbweb）。组学是一种研究健康和疾病生物学的系统生物学方法，也是“个性化医疗”出现的关键关键。为肺部疾病组学提供职业发展支持对于医生/科学家和博士科学家来说是及时且非常重要的一个基本问题是利用多级组学数据源的系统生物学方法异常多学科，需要 肺部研究人员在许多学术领域拥有工作专业知识，这些领域以前被认为是独特的（又名“孤立的”）。 K12组学职业发展项目的关键挑战是打破学术医学的传统孤岛，为学者提供一个大型研究工具箱，范围从表观基因组学到下一代序列数据的生物信息学，再到表型/环境相互作用。我们的 K12 项目通过为学者提供时间来满足这一需求：1）学习与其研究相关的组学和系统生物学课程； 2) 学习基因组学、蛋白质组学和生物信息学领域最先进的实验室方法； 3) 在首席导师和指导团队的监督下开发初步数据，从而提交独立的 NIH 拨款申请； 4) 学会有效地将他们的成就转化为改善儿科肺部疾病。为了实现他们的目标，K12 学者将花费至少 75% 的精力在 1-3 年的时间内磨练这些技能，具体取决于过去的经验和主题领域。在此期间，上述每个目标都以系统的方式得到实现，包括参与研究方法和生物统计学的核心课程，以及在首席导师的实验室中进行日益独立的研究。我们提议的 K12 计划从 ISB/GenMed 名册中吸引了 11 名首席导师和 16 名二级导师，他们将在四个亲和领域担任导师团队：遗传学和基因组学；蛋白质组学；生物信息学、临床和临床前表型分析。 K12 的管理结构包括两名在组学和肺生物学/疾病方面具有互补专业知识的联合首席研究员，他们将分别担任项目总监和职业发展总监、少数族裔招聘总监以及内部和外部咨询委员会。我们建议在 5 年资助期内选拔和培训总共 2-4 名 K12 学者。