Non-invasive Blood Alcohol Sensor for Emergency Room Applications

适用于急诊室应用的无创血液酒精传感器

• 批准号: 8902744
• 负责人: Manal Beshay
• 金额: $ 73.93万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-10 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902744
• 关键词: Accident and Emergency department; Address; Alcoholic Intoxication; Alcohols; Amphetamines; Area; Barbiturates; Benzodiazepines; Blood; Blood alcohol level measurement; Blood specimen; Body Fluids; Buffers; Businesses; Clinical; Cocaine; Collaborations; Craniocerebral Trauma; Data; Detection; Development; Diabetes Mellitus; Diagnosis; Drug Monitoring; Emergency Care; Emergency Department patient; Emergency Medicine; Emergency Situation; Ensure; Evaluation; Government; Hand; Health; Health Personnel; Health Sciences; Healthcare; Human; Intake; Intoxication; Judgment; Label; Left; Marketing; Measurement; Measures; Mentally Disabled Persons; Metabolic Biotransformation; Methods; Modeling; Monitor; Opiates; Optics; Patients; Performance; Persons; Pharmaceutical Preparations; Phase; Process; Reaction Time; Reagent; Reporting; Saliva; Sampling; Stroke; System; Techniques; Testing; Texas; Time; Unconscious State; Universities; Urine; Visual; alcohol measurement; alcohol monitoring; alcohol screening; artist; base; clinically relevant; commercialization; compliance behavior; design; detector; drug of abuse; improved; rapid diagnosis; screening; sensor; tool; urinary

DESCRIPTION (provided by applicant): Project Summary Accurate quantification of alcohol and drugs of abuse intoxication in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergencies such as traumatic head injury, diabetes, and stroke can be misdiagnosed in the absence of screening for alcohol and drug intoxication; reliable measurement of alcohol and drug intake levels would improve diagnosis and subsequent treatment in these cases. Most methods now used in emergency rooms either require patient cooperation and interaction, such as a Breathalyzer, or are invasive and have prolonged processing times, such as blood and urine sample analysis, making them inappropriate for ER applications. In particular, patients suffering from drug and alcohol intoxication are often not able, or are unwilling, to interact with medical personnel, hence the need for easier sampling and reliable measurement. To address this need, Intelligent Optical Systems is collaborating with Dr. Robert Woolard of Texas Tech University Health Science Center (TTUHSC) Emergency Medicine Department, a recognized expert in alcohol and drugs of abuse in ER-related studies, in our development for a non-invasive saliva-based analyzer for ER applications. The analyzer measures emissions of fluorescent-labeled selective reagents to detect alcohol and drugs of abuse in saliva samples. Although saliva monitoring is an established area for alcohol and drugs of abuse, accurate quantitative measurements are still needed to quantify the intoxication levels in admitted ER patients without relying on visual judgments. In Phase I we demonstrated the feasibility of achieving reproducible, highly sensitive measurements of alcohol levels in buffer and modeled saliva, as well as in 30 human saliva samples obtained by Dr. Woolard and TTUHSC that were tested and compared to blood levels. In Phase II we will test an additional 100 human samples to expand the statistical data and determine sensor accuracy and precision levels, introduce a method for quantitative (high/mid/low) measurement of six drugs of abuse (opiates, cocaine, amphetamines, THC, benzodiazepines, barbiturates), and develop the portable readout system. The objective is a simple yet highly accurate optical detection platform suitable for bedside ER applications, with further potential for widespread clinical monitoring applications in many healthcare settings.

描述（由申请人提供）： 项目摘要准确地量化酒精和急诊室滥用中毒药物（ERS）是进行精确诊断的重要筛查步骤，因此可以及时治疗。在没有筛查酒精和药物中毒的情况下，可能会误诊一些严重的紧急情况，例如头部损伤，糖尿病和中风。在这些情况下，可靠测量酒精和药物摄入水平将改善诊断和随后的治疗。现在，急诊室中使用的大多数方法都需要患者的合作和相互作用，例如呼吸分析仪，或者具有侵入性并具有延长的加工时间，例如血液和尿液样本分析，使其不适合ER应用。特别是，患有毒品和酒精中毒的患者通常无法或不愿意与医务人员互动，因此需要更容易的采样和可靠的测量。为了满足这一需求，智能光学系统正在与德克萨斯理工大学健康科学中心（TTUHSC）急诊医学部的罗伯特·伍德（Robert Woolard）合作，这是急诊室研究中公认的酒精和滥用药物专家，用于我们的非侵入性唾液基于ER应用的分析仪的开发。分析仪测量了荧光标记的选择性试剂的排放，以检测唾液样品中的酒精和滥用药物。尽管唾液监测是酒精和滥用药物的既定领域，但仍需要准确的定量测量来量化入院患者的中毒水平，而无需依赖视觉判断。在第一阶段，我们证明了在缓冲液和建模的唾液中获得可再现的，高度敏感的酒精水平的可行性，以及在Woolard和TTUHSC博士获得的30种人类唾液样本中，并与血液水平进行了比较。在第二阶段，我们将测试另外100个人类样本，以扩大统计数据并确定传感器的准确性和精度水平，引入了一种对六种滥用药物进行定量（高/中/低）测量的方法（Opiates，Cocaine，Cocaine，Amphetamine，THC，Benzodiazepines，Barbitines，barbitrates，barbitrates），并开发便携式读取系统。该目标是一个简单而又高度准确的光学检测平台，适用于床头ER应用，在许多医疗机构中，具有广泛的临床监测应用可能性的进一步潜力。