Non-invasive Blood Alcohol Sensor for Emergency Room Applications

适用于急诊室应用的无创血液酒精传感器

• 批准号: 8125190
• 负责人: Manal Beshay
• 金额: $ 18.16万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-10 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125190
• 关键词: Accident and Emergency department; Address; Affinity; Alcohol consumption; Alcoholic Intoxication; Alcohols; Binding; Biological Assay; Blood; Blood alcohol level measurement; Body Fluids; Buffers; Chemicals; Clinical; Collaborations; Complex; Craniocerebral Trauma; Detection; Diabetes Mellitus; Diagnosis; Diagnostic; Diffusion; Elements; Emergency Care; Emergency Medicine; Emergency Situation; Ethanol; Evaluation; Funding; Future; Glass; Government; Hand; Health Sciences; Healthcare; Human; Immobilization; Left; Marketing; Measurement; Measures; Metabolic Biotransformation; Methods; Modeling; Monitor; Optics; Patients; Persons; Phase; Protocols documentation; Reporting; Research; Ruthenium; Saliva; Sampling; Screening procedure; Security; Stroke; System; Techniques; Testing; Texas; Time; Universities; Urine; Water; Work; alcohol measurement; alcohol monitoring; alcohol screening; artist; base; clinical application; compliance behavior; design; detector; drug of abuse; improved; meetings; sensor; tool

DESCRIPTION (provided by applicant): Accurate quantification of blood alcohol in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergencies such as traumatic head injury, diabetes, and stroke can be misdiagnosed as alcohol intoxication. A reliable measurement of blood-alcohol would improve diagnosis in these cases. Intelligent Optical Systems proposes to develop a non-invasive sensor for alcohol for emergency room (ER) applications, based on emission lifetime measurements of a ruthenium-based complex. The sensor design will be suitable for situations in which patient interaction and cooperation is not required or is not available. The objective is a simple optical detection platform with high accuracy in blood alcohol measurements, leading to fast, yet adequate treatment. Such a system can be expected to have widespread application for clinical assays in many health care settings, for screening alcohol intake, and for monitoring treatment efficiency. The ruthenium-based complex will be covalently attached to a porous glass matrix. As the saliva sampling occurs, alcohol molecules will interact with bound ruthenium indicator and cause emission quenching. Detection by means of emission measurements will be enhanced by using a highly stable fluorescent ruthenium complex. Phase I will focus on demonstrating the feasibility of achieving reproducible, sensitive measurements of alcohol levels in buffer and modeled saliva. Human saliva samples will be tested and compared to blood levels, through our collaboration with Prof. Robert Woolard of Texas Tech University Health Science Center's Emergency Medicine Department. Prof. Woolard is a recognized expert in alcohol chemical and ER-related studies. Phase II will demonstrate sensor sensitivity and reliability in real saliva samples to validate detection accuracy meeting ER requirements. The final commercial product will address markets such as health care diagnostics, homeland security, and clinical monitoring. The system will have the capability to be extended to testing for drugs of abuse with future additional research funding that will cover multiple testing criteria in ER applications. PUBLIC HEALTH RELEVANCE: Intelligent Optical Systems proposes to develop a new technique for saliva-alcohol measurements in emergency rooms. The detector will have the measurement accuracy required in emergency rooms without the need for active patient interaction, and will therefore contribute to quick diagnosis and appropriate treatment.

描述（由申请人提供）：准确量化急诊室（ERS）的血液酒精是进行精确诊断的重要筛查步骤，因此可以及时治疗。一些严重的紧急情况，例如造成创伤性的头部损伤，糖尿病和中风，可以被误诊为酒精中毒。在这些情况下，可靠的血液酒精测量可以改善诊断。智能光学系统建议根据基于芳族的综合体的发射寿命测量来开发急诊室（ER）应用的非侵入性传感器。传感器设计适用于不需要或不可用的患者互动和合作的情况。该目标是一个简单的光学检测平台，具有高精度的血液酒精测量，​​导致快速但足够的治疗。可以预期，在许多医疗保健环境中，筛查酒精摄入和监测治疗效率的临床测定法可以广泛应用。基于芳基的络合物将共价连接到多孔玻璃基质上。随着唾液采样的发生，酒精分子将与结合的松en剂指标相互作用，并引起排放淬火。通过使用高度稳定的荧光松子络合物将通过发射测量进行检测。第一阶段将集中于证明在缓冲液和建模的唾液中实现可重复的，对酒精含量的可重复测量的可行性。通过与德克萨斯理工大学健康科学中心急诊医学部的罗伯特·伍德拉德（Robert Woolard）的合作，将对人类唾液样本进行测试并与血液水平进行比较。 Woolard教授是酒精化学和与ER相关研究的公认专家。第二阶段将在实际唾液样品中证明传感器的灵敏度和可靠性，以验证满足ER要求的检测准确性。最终的商业产品将解决医疗保健诊断，国土安全性和临床监测等市场。该系统将有能力扩展到对滥用药物的测试，并提供未来的额外研究资金，这些资金将涵盖ER应用中的多个测试标准。 公共卫生相关性：智能光学系统建议在急诊室开发一种用于唾液 - 酒精测量的新技术。该检测器将在急诊室需要测量精度，而无需进行主动患者互动，因此将有助于快速诊断和适当的治疗。