Increasing HPV Vaccine Uptake in a Low Income Ethnic Minority Population

提高低收入少数族裔人群对 HPV 疫苗的接种率

• 批准号: 8831606
• 负责人: Roshan Bastani
• 金额: $ 55.63万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8831606
• 关键词: Address; Affect; Age; Asians; Attitude; Belief; Centers for Disease Control and Prevention (U.S.); Clinic; Comprehensive Cancer Center; Control Groups; County; Daughter; Development; Disease; Dose; Education; English Language; Ensure; Goals; Health; Health Services; Health Services Accessibility; Health education; Health system; Healthcare; Hotlines; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Immigrant; Immunization; Incidence; Institutionalization; Intervention; Interview; Knowledge; Koreans; Latina; Los Angeles; Low income; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mediator of activation protein; Minority; Morbidity - disease rate; Mothers; Pacific Island Americans; Pamphlets; Participant; Patient Self-Report; Pattern; Printing; Protocols documentation; Public Health; Public Health Schools; Randomized; Registries; Research Infrastructure; Sampling; Series; Services; Source; Subgroup; Target Populations; Telephone; Telephone Interviews; Time; United States; Vaccines; Woman; Women' s Health; arm; cervical cancer prevention; cost; demographics; ethnic minority population; follow-up; girls; group intervention; high risk; innovation; intervention effect; mortality; multi-component intervention; primary outcome; randomized trial; treatment as usual; uptake

DESCRIPTION (provided by applicant): Cervical cancer incidence in Los Angeles County is significantly higher than the national average, with highest rates among Latinas and Asian/Pacific Islanders. The discovery of HPV as the primary causal agent in cervical cancer and subsequent development of HPV vaccines have revolutionized the potential for cervical cancer prevention. However, vaccine utilization rates in the US remain unacceptably low among age-eligible girls, including among the highest risk groups. The UCLA School of Public Health & Jonsson Comprehensive Cancer Center have teamed with the Los Angeles County Department of Public Health, Office of Women's Health (OWH) to address the unequal burden of cervical cancer in Los Angeles. The primary goal of the study is to evaluate, in a randomized trial, a theoretically driven, culturally sensitive and individually tailored intervention to increase HPV vaccine receipt among underserved, high risk girls in Los Angeles. The intervention will be delivered via the existing OWH telephone education and service referral hotline in six languages (English, Spanish, Cantonese, Mandarin, Korean, Armenian). The multi-component intervention, directed at mothers of age-eligible girls (11-18 years), will consist of a brief telephone intervention that will deliver basic HPV vaccine information, individually tailored messages to address callers' barriers to HPV vaccination, and tailored referral to a clinic offering low cost/free vaccine. A tailored print intervention reinforcing the telephone messages will also be mailed to participants. The control group will receive usual care and a standard CDC fact sheet on the HPV vaccine. The primary outcome will be vaccine initiation among age-eligible girls (receipt of at least one vaccine dose) assessed at a 3 month telephone follow-up with mothers. A 9 month follow-up will assess vaccine completion rates (receipt of 3-dose series) and overall patterns of vaccine dose initiation and completion. The study also seeks to characterize HPV related knowledge, beliefs and barriers in the target population, and understand the mediators (e.g., knowledge, barriers reduction) through which the intervention may have achieved its desired effect. Differential effects of the intervention on subgroups of the sample (e.g., more acculturated) will also be assessed. The study is innovative in that we are partnering with the county health system which is the only realistic source of health care for our target population. The commitment of the county department of public health to increasing HPV vaccine uptake and the utilization of existing county infrastructure (the OWH hotline) for intervention delivery will ensure institutionalization of the intervention upon trial completion.

描述（由申请人提供）：洛杉矶县的宫颈癌发病率明显高于全国平均水平，拉丁裔和亚洲/太平洋岛民的率最高。 HPV作为宫颈癌的主要因果剂的发现以及随后的HPV疫苗开发彻底改变了预防宫颈癌的潜力。但是，在美国符合年龄符合年龄的女孩（包括最高风险群体）中，美国的疫苗利用率仍然不可接受。加州大学洛杉矶分校公共卫生与琼森综合癌症中心与洛杉矶县公共卫生部，妇女健康办公室（OWH）合作解决了洛杉矶宫颈癌不平等的负担。该研究的主要目的是在一项随机试验中评估理论上驱动的，文化敏感且量身定制的干预措施，以增加洛杉矶服务不足的高风险女孩的HPV疫苗收入。干预措施将通过现有的OWH电话教育和服务推荐热线提供六种语言（英语，西班牙语，广东话，普通话，韩语，亚美尼亚语）。多功能干预措施针对符合年龄的女孩（11-18岁）的母亲，将由短暂的电话干预组成，该干预将提供基本的HPV疫苗信息，单独定制的消息，以解决呼叫者的HPV疫苗接种障碍，并针对低成本/免费疫苗量身定制。量身定制的打印干预措施也将邮寄给参与者。对照组将在HPV疫苗上接受常规护理和标准的CDC情况表。主要结果将是在3个月的电话随访中评估的符合年龄的女孩（至少收到一种疫苗剂量的接收疫苗剂量）的疫苗开始。 9个月的随访将评估疫苗的完成率（收到3剂量系列）和疫苗剂量启动和完成的总体模式。该研究还试图表征目标人群中相关的知识，信念和障碍，并了解介体（例如，知识，减少障碍），通过这些知识，减少障碍）可能实现了其所需的效果。干预措施对样品亚组的差异影响（例如，更适应）也将进行评估。这项研究具有创新性，因为我们正在与县卫生系统合作，这是目标人群的唯一现实医疗保健来源。县公共卫生部致力于增加HPV疫苗的吸收和现有县基础设施（OWH热线）进行干预提供的承诺，将确保在审判完成后制度化干预措施。