Stress Biomarkers as a Potential Link Between Age Beliefs and Health

压力生物标志物是年龄信念与健康之间的潜在联系

基本信息

批准号：
8929104
负责人：
BECCA R LEVY
金额：
$ 16.15万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-30 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8929104
关键词：
African American Age Aged, 80 and over Aging Alzheimer&apos s Disease Baltimore Belief Biological Biological Assay Biological Markers Biological Process Categories Chronic stress Cognitive Communities Data Analyses Data Set Development Elderly Emotional Event Feeling Foundations Future Gender Goals Health Hippocampus (Brain)Hydrocortisone Individual Intervention Life Link Longevity Longitudinal Studies Measures Mediating Mediator of activation protein Memory impairment Modeling Negative Finding Outcome Perception Physical Function Physiological Process Research Research Personnel Retirement Risk Sampling Societies Strategic Planning Stress System Time United States National Institutes of Health aged cardiovascular risk factor design health belief improved longitudinal analysis men mild cognitive impairment mortality novel older men older women physical conditioning research study response secondary outcome

项目摘要

DESCRIPTION (provided by applicant): Experimental and longitudinal studies have found that older individuals with more negative age beliefs demonstrate worse health outcomes. The mechanism that explains this process is not known. The overall aim of the proposed project is to investigate for the first time whether stress biomarkers over time reflect a biological process tha links negative age beliefs (defined as disparaging perceptions that are assimilated from society about older individuals as a category) with worse health of older individuals. The importance of examining stress biomarkers as the potential mechanism is enhanced by their potential ability to provide a previously unexamined explanation for racial and gender disparities in aging health. The proposed project will draw on two ongoing complementary longitudinal datasets that focus on community-dwelling older individuals. Thus, we will pursue the following aims and hypotheses for the first time: Aim 1: Examine whether older individuals' age beliefs are associated with stress biomarkers over time. Hypothesis 1: Older individuals' negative age beliefs will predict elevated stress biomarkers over time. Aim 2: Examine whether racial and gender disparities exist in the influence of older individuals' age beliefs on stress biomarkers over time. Hypothesis 2a: Older African Americans will be more vulnerable than same-aged older whites to the adverse impact of negative age beliefs on stress biomarkers over time. Hypothesis 2b: Older women will be more vulnerable than same-aged older men to the adverse impact of negative age beliefs on stress biomarkers over time. Aim 3: Examine whether older individuals' stress biomarkers over time mediate the relationship between age beliefs and worse cognitive and physical health over time. Hypothesis 3: Older individuals' stress biomarkers will mediate the relationship between negative age beliefs and worse cognitive health (i.e., memory deficits, risk of mild cognitive impairment and Alzheimer's disease, and smaller hippocampal volume) and worse physical health (i.e., physical-function deficits, risk of cardiovascular events, and higher mortality) over time. Aim 4: Identify the factors that moderate negative age beliefs' influence on older individuals' stress biomarkers over time. Hypothesis 4: Resiliency factors (i.e. Feeling Useful to Others, Openness, and Emotional Stability) and vulnerability factors (i.e., Age-belief Self-relevance and Adverse Life Events) will moderate negative age beliefs' effect on stress biomarkers over time. This study could identify a new and potentially modifiable process, negative age beliefs' association with stress biomarkers over time, as a factor that contributes to adverse health outcomes among older individuals.

描述（由申请人提供）：实验和纵向研究发现，年龄较大的老年人的健康状况较差。解释这一过程的机制尚不清楚。拟议项目的总体目的是首次调查压力生物标志物随着时间的流逝是否反映了一个生物学过程，这是一个负面的年龄信念（定义为贬低的看法，这些看法是从社会上吸收的，对老年人作为一个类别），年龄较大的人的健康状况较差。研究应力生物标志物作为潜在机制的重要性是由于其潜在的能力提供了以前未见的对衰老健康中种族和性别差异的解释的能力。拟议的项目将利用两个正在进行的互补纵向数据集，这些数据集的重点是社区居住的老年人。因此，我们将首次追求以下目标和假设：目标1：检查老年人的年龄信念是否随着时间的推移与压力生物标志物有关。假设1：老年人的负年龄信念将随着时间的推移预测应力生物标志物的升高。 AIM 2：检查年龄较大的人的年龄信仰对压力生物标志物随着时间的推移的影响是否存在种族和性别差异。假设2a：年龄较大的非洲裔美国人比同龄老年白人更容易受到负面年龄信念对压力生物标志物的不利影响。假设2b：老年妇女比同龄年龄较大的男性更容易受到负面年龄信念对压力生物标志物的不利影响。 AIM 3：检查年龄较大的人的压力生物标志物是否会随着时间的流逝调解年龄信念与差的认知和身体健康之间的关系。假设3：老年人的压力生物标志物将介导负年龄信念与认知健康差（即记忆缺陷，轻度认知障碍的风险和阿尔茨海默氏病的风险，以及较小的海马体积）以及身体健康较差的身体健康（即身体功能不足，心血管疾病的风险，较高的心血管疾病）和较高的过度越来越多的时间。目标4：确定随着时间的流逝，中度负面年龄信念对老年人压力生物标志物的影响的因素。假设4：弹性因素（即对他人有用，开放性和情感稳定性）和脆弱性因素（即，年龄增强的自我 - 自我意识和不良生活事件）将随着时间的推移而对压力生物标志物的影响进行适度的负面影响。这项研究可以确定一个新的且潜在的可修改过程，随着时间的流逝，负面的年龄信念与压力生物标志物的关联是有助于老年人不良健康结果的一个因素。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials.

DOI：
10.1529/biophysj.103.037812
发表时间：
2004-06
期刊：
Biophysical journal
影响因子：
3.4
作者：
M. Valentine;Z. Perlman;M. Gardel;J. Shin;P. Matsudaira;T. Mitchison;D. Weitz
通讯作者：
M. Valentine;Z. Perlman;M. Gardel;J. Shin;P. Matsudaira;T. Mitchison;D. Weitz

Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.

美国退伍军人 DNA 甲基化加速老化：国家退伍军人健康和复原力研究的结果。

DOI：
10.1016/j.jagp.2019.01.001
发表时间：
2019
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
0
作者：
Tamman,AmandaJF;Montalvo-Ortiz,JanitzaL;Southwick,StevenM;Krystal,JohnH;Levy,BeccaR;Pietrzak,RobertH
通讯作者：
Pietrzak,RobertH

Subthreshold post-traumatic stress disorder as a risk factor for post-traumatic stress disorder: results from a sample of USA veterans.

阈下创伤后应激障碍作为创伤后应激障碍的危险因素：来自美国退伍军人样本的结果。