FASEB SRC on Helicases and Nucleic-Acid Based Machines: From Mechanism to Insights into Disease

FASEB SRC 关于解旋酶和核酸机器：从机制到洞察疾病

• 批准号: 8986287
• 负责人: Maria Spies
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986287
• 关键词: Address; Advertising; Aging; American; Area; Award; Biological Preservation; Biology; Biophysics; Bloom Syndrome; California; Caring; Cell division; Cell physiology; Cells; Chemistry; Child; Cities; Cockayne Syndrome; Colorado; Complex; DNA biosynthesis; Data; Defect; Development; Diagnosis; Disabled Persons; Disease; Electronic Mail; Environment; Enzymes; Family; Fanconi' s Anemia; Fees; Female; Foundations; Gene Expression; Gene Expression Regulation; Genetic; Genetic Materials; Genomic Instability; Growth; Health; Housing; Human; Immunodeficiency and Cancer; Immunologic Deficiency Syndromes; Information Technology; Inherited; Iowa; Journals; Knowledge; Longevity; Malignant Neoplasms; Metabolism; Minority; Molecular; Molecular Machines; Molecular Structure; Nature; Newsletter; Nucleic Acids; Nucleoproteins; Participant; Play; Pluripotent Stem Cells; Predisposition; Premature aging syndrome; Process; Proteins; Publishing; RNA; RNA Helicase; RNA Processing; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Resort; Resources; Role; Science; Scientific Societies; Scientist; Site; Societies; Speed; Structure; Switzerland; System; Time; Trichothiodystrophy; Underrepresented Minority; Universities; Werner Syndrome; Woman; Xeroderma Pigmentosum; base; chromatin remodeling; ds-DNA; experience; graduate student; grasp; helicase; human disease; improved; innovation; insight; interest; malignant breast neoplasm; meetings; nervous system disorder; nucleic acid metabolism; posters; programs; public health relevance; recombinational repair; segregation; single molecule; structural biology; success; symposium; translocase

 DESCRIPTION (provided by applicant): This application requests support for the 2015 summer research conference on "Helicases and Nucleic- Acid Based Machines: From Mechanism to Insight into Disease". The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 26-31, 2015, in Steamboat Springs, Colorado. The conference organizers are Maria Spies (University of Iowa, Iowa City, USA) and Karsten Weis (University of California, Berkeley, USA, and ETH Zurich, Switzerland). Due to their capacity to unwind structures of double-stranded DNA and RNA, and to remodel nucleoprotein complexes, helicases and helicase-like translocases are critical components of numerous nucleic acid processing machines. Consequently, their activities are obligatory to all cellular information transactions and defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. In recent years, the field has developed a first grasp of the basic mechano-chemistry and general structural organization of both RNA- and DNA helicases. Furthermore, we have come to appreciate the importance of these enzymes for many fundamental cellular processes. The development and application of many cutting edge experimental approaches ranging from structural biology and single- molecule biophysics to manipulation of pluripotent stem cells for the study of these systems attend to this fact. The critical roles of helicases in the regulation o DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, combined with the breadth of the experimental approaches applied to helicases has created a growing need for an exchange of information among the diverse group of scientists studying the helicase structure, regulation, molecular and cellular functions, and disease-processes associated with defects in or dysregulation of these enzymes. To address this need, the ninth bi-annual meeting on Helicases and Nucleic-Acid Based Machines aims at expanding the helicases related research. It will promote the information exchange among experienced and young investigators studying RNA and DNA helicases and helicase-like translocases, and will integrate the knowledge obtained through a broad range of experimental strategies. The meeting will focus on understanding the regulation of these enzymes, how they fit into supramolecular machines of the cell, and how the knowledge of their structures and mechanisms can be exploited to improve human health. The FASEB conference format combines an optimally sized meeting (approximately 150 participants) with an environment that promotes continuous formal and informal interactions between the participants. It will allow us to emphasize truly exceptional research and provide opportunities for the exchange of information, technology and perspective on helicases and helicase-like translocases.

 描述（由申请人提供）：本申请请求支持 2015 年夏季研究会议“解旋酶和核酸机器：从机制到洞察疾病”该会议由美国实验生物学会联合会 (FASEB) 赞助。 ）将于 2015 年 7 月 26 日至 31 日在科罗拉多州斯廷博特斯普林斯举行，会议组织者为 Maria Spies（爱荷华大学，爱荷华市）。美国）和 Karsten Weis（美国加州大学伯克利分校和瑞士苏黎世联邦理工学院）由于解旋酶和解旋酶样转位酶能够解开双链 DNA 和 RNA 结构以及重塑核蛋白复合物，因此至关重要。经过测试，它们的活动对于所有细胞信息处理都是必需的，并且这些酶的缺陷与包括癌症和过早衰老在内的多种人类疾病有关。该领域首次掌握了 RNA 和 DNA 解旋酶的基本机械化学和一般结构组织。此外，我们已经认识到这些酶对于许多基本细胞过程的重要性以及许多前沿技术的开发和应用。用于研究这些系统的从结构生物学和单分子生物物理学到操纵多能干细胞的实验方法都关注这一事实，即解旋酶在 DNA 复制、修复、重组和基因表达的调节中发挥着关键作用。它们在许多疾病中的失调，加上应用于解旋酶的实验方法的广泛性，使得研究解旋酶结构、调节、分子和细胞功能以及相关疾病过程的不同科学家群体之间越来越需要信息交流为了满足这一需求，第九届解旋酶和核酸机器会议旨在扩大解旋酶相关研究，它将促进经验丰富的和年轻的研究人员之间的信息交流。研究 RNA 和 DNA 解旋酶以及类解旋酶易位酶，并将整合通过广泛的实验策略获得的知识，会议将重点了解这些酶的调节、它们如何适应细胞的超分子机器以及如何发挥作用。 FASEB 会议形式将最佳规模的会议（约 150 名参与者）与促进参与者之间持续的正式和非正式互动的环境相结合。将使我们能够强调真正杰出的研究，并为关于解旋酶和解旋酶样易位酶的信息、技术和观点的交流提供机会。